anti-HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) Antikörper

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Zusätzlich bieten wir Ihnen HACE1 Kits (10) und HACE1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HACE1 57531 Q8IYU2
HACE1 209462 Q3U0D9
HACE1 361866 D3ZBM7
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Top anti-HACE1 Antikörper auf antikoerper-online.de

Showing 10 out of 27 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-HACE1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>Hela cell lysate Host: Rabbit <br /> Target Name: HACE1 <br /> Sample Tissue: Hela Whole cell <br /> Lane A:  Primary Antibody Lane B: Primary Antibody + Blocking Peptide <br />Primary Antibody Concentration: 1 µg/mL Peptide Concentration: 5 µg/mL Lysate Quantity: 41 µg/lane/LaneGel Concentration:.12 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon labeled with Anti HACE1 Polyclonal Antibody, Unconjugated (ABIN761141) followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human colon labeled with Anti HACE1 Polyclonal Antibody, Unconjugated  followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
304,36 €
Details
Human Kaninchen Unkonjugiert WB HACE1 antibody used at 1 ug/ml to detect target protein. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
495,58 €
Details
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
459,65 €
Details
Meerschweinchen Kaninchen Unkonjugiert WB   50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Human Kaninchen Unkonjugiert ICC, IF Immunocytochemistry/Immunofluorescence: HACE1 Antibody  - Staining of human cell line U-2 OS shows localization to endoplasmic reticulum. 100 μL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details
Human Maus Biotin IF, IHC (p), ELISA, WB   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
530,79 €
Details
Human Maus FITC IF, IHC (p), ELISA, WB   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
548,26 €
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HACE1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine) ,


Rat (Rattus) ,


Weitere Antikörper gegen HACE1 Interaktionspartner

Human HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) Interaktionspartner

  1. 3-deazaneplanocin A treatment increased HACE1 gene expression which was further increased by the addition of trichostatine A (TSA (zeige PRDX2 Antikörper)), a promising therapeutic compound for the treatment of human B-Lymphoma

  2. Mechanistic studies showed that HACE1 exerts its inhibitory role on virus-induced signaling by disrupting the MAVS (zeige MAVS Antikörper)-TRAF3 (zeige TRAF3 Antikörper) complex.

  3. HACE1 can act as a haploinsufficient tumor suppressor gene in most B-cell lymphomas and can be downregulated by deacetylation of its promoter region chromatin

  4. Hepatocellular carcinoma patients with low HACE1 expression levels exhibited poorer overall survival and HACE1 was found to be an independent prognostic factor for survival.

  5. HACE1 as a specific E3 ligase that polyubiquitinates YB-1 through non-canonical K27 linked ubiquitin chains.

  6. Biallelic loss-of-function mutations in HACE1 are associated with an autosomal recessive neurodevelopmental syndrome.

  7. supports a critical role for HACE1 in breast cancer progression and identifies patients that may benefit from Rac (zeige AKT1 Antikörper)-targeted therapies

  8. contrary to previous report, overexpression of HACE1 by transduction of recombinant protein did not affect proliferation or survival of NKTCL cell lines. We therefore conclude that HACE1 is not directly involved in NKTCL pathophysiology

  9. HACE1-OPTN (zeige OPTN Antikörper) axis synergistically suppresses growth and tumorigenicity of lung cancer cells.

  10. Ubiquitylation and activation of RAB11a (zeige RAB11A Antikörper) is promoted by a beta2 adrenergic receptor (zeige ADRB2 Antikörper)-HACE1 complex.

Mouse (Murine) HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) Interaktionspartner

  1. HACE1 controls TNF (zeige TNF Antikörper)-elicited cell fate decisions and exerts tumor suppressor and anti-inflammatory activities via a TNFR1 (zeige TNFRSF1A Antikörper)-RIP3 (zeige MPRIP Antikörper) kinase-necroptosis pathway.

  2. Increased reactive oxygen species (ROS (zeige ROS1 Antikörper)) production due to Hace1 loss leads to glutamine (zeige GFPT1 Antikörper) addiction as a mechanism to cope with increased ROS (zeige ROS1 Antikörper)-induced oxidative stress.

  3. Data indicate that HECT E3 ubiquitin ligase (zeige MUL1 Antikörper) HACE1 deficiency accelerates pressure overload-induced heart failure.

  4. HACE1-OPTN (zeige OPTN Antikörper) axis synergistically suppresses growth and tumorigenicity of lung cancer cells.

  5. Hace1 controls ROS (zeige ROS1 Antikörper) generation of vertebrate Rac1-dependent NADPH oxidase (zeige NOX1 Antikörper) complexes.

HACE1 Antigen-Profil

Protein Überblick

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB (By similarity).

Genbezeichner und Symbole assoziert mit HACE1

  • HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (HACE1) Antikörper
  • HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (HACE1) Antikörper
  • HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 (hace1) Antikörper
  • HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (LOC100342048) Antikörper
  • HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (hace1) Antikörper
  • HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 (Hace1) Antikörper
  • 1700042J16Rik Antikörper
  • A730034A22Rik Antikörper
  • BC025474 Antikörper
  • HACE1 Antikörper

Bezeichner auf Proteinebene für HACE1

HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 , E3 ubiquitin-protein ligase HACE1 , HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 , E3 ubiquitin-protein ligase HACE1-like , e3 ubiquitin-protein ligase HACE1-like

GENE ID SPEZIES
100071887 Equus caballus
462900 Pan troglodytes
734146 Xenopus (Silurana) tropicalis
100342048 Oryctolagus cuniculus
100399774 Callithrix jacchus
100438368 Pongo abelii
100475389 Ailuropoda melanoleuca
100548893 Meleagris gallopavo
100562508 Anolis carolinensis
100581995 Nomascus leucogenys
446912 Xenopus laevis
421788 Gallus gallus
57531 Homo sapiens
475010 Canis lupus familiaris
100156102 Sus scrofa
527565 Bos taurus
209462 Mus musculus
361866 Rattus norvegicus
Ausgewählte Anbieter für anti-HACE1 (HACE1) Antikörper
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