anti-HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) Antikörper

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Zusätzlich bieten wir Ihnen HECW2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HECW2 316395  
HECW2 57520 Q9P2P5
HECW2 329152 Q6I6G8
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Top anti-HECW2 Antikörper auf antikoerper-online.de

Showing 10 out of 47 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from LOVO/HepG2 cells, using HECW2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$221.76
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of HECW2 Antibody (Center) in mouse brain tissue lysates (35ug/lane). This demonstrates the HECW2 antibody detected the HECW2 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert ELISA, WB 100 μL Anmelden zum Anzeigen 16 Days
$175.80
Details
Human Kaninchen Unkonjugiert WB HECW2 Antibody (Center)  western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the HECW2 antibody detected the HECW2 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged HECW2 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Kaninchen Unkonjugiert IC, IF, WB Immunofluorescent analysis of HECW2 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of HECW2 expression in A549 (A), NIH3T3 (B) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Huhn Ziege Unkonjugiert ELISA   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$507.83
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry: NEDL2 Antibody [NBP1-92174] - Staining of human lung shows strong cytoplasmic positivity in subsets of alveolar cells. Immunocytochemistry/Immunofluorescence: NEDL2 Antibody  - Staining of human cell line A-431 shows localization to endoplasmic reticulum. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$439.69
Details
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged HECW2 is approximately 0.3ng/ml as a capture antibody. Western Blot detection against Immunogen (37.73 KDa) . 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$430.00
Details

HECW2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen HECW2 Interaktionspartner

Human HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) Interaktionspartner

  1. HECW2, a novel EC ubiquitin E3 ligase, plays a critical role in stabilizing endothelial cell-to-cell junctions by regulating AMOT (zeige AMOT Antikörper)-like 1 (AMOTL1 (zeige AMOTL1 Antikörper)) stability.

  2. HECW2 is an ubiquitin ligase that stabilises p73 (zeige TP73 Antikörper), a crucial mediator of neurodevelopment and neurogenesis. This study implicates pathogenic genetic variants in HECW2 as potential causes of neurodevelopmental disorders in humans.

  3. This work lends further support to previously identified candidate gene HECW2 as a novel candidate gene in intellectual disability and epilepsy. In 39 patient-parent trios, 29 de novo mutations in coding sequence were identified.

  4. Low HECW2 expression is associated with cervical cancer.

  5. NEDL2 is a novel substrate of APC (zeige APC Antikörper)/C-Cdh1 (zeige CDH1 Antikörper) as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition

Mouse (Murine) HECT, C2 and WW Domain Containing E3 Ubiquitin Protein Ligase 2 (HECW2) Interaktionspartner

  1. NEDL2 positively regulates enteric neural precursor proliferation through the GDNF/Akt (zeige AKT1 Antikörper) signaling pathway.

  2. Grk2 (zeige ADRBK1 Antikörper) phosphorylates the C terminus of the Na-channel beta subunit (zeige POLG Antikörper) and renders the channels insensitive to inhibition by Nedd4-2 (zeige NEDD4L Antikörper)

HECW2 Antigen-Profil

Protein Überblick

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (By similarity).

Genbezeichner und Symbole assoziert mit HECW2

  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (Hecw2) Antikörper
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (HECW2) Antikörper
  • E3 ubiquitin-protein ligase HECW2 (LOC531691) Antikörper
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b (hecw2b) Antikörper
  • HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 (hecw2) Antikörper
  • A730039N16Rik Antikörper
  • D030049F17Rik Antikörper
  • Gm971 Antikörper
  • HECW2 Antikörper
  • mKIAA1301 Antikörper
  • Nedl2 Antikörper

Bezeichner auf Proteinebene für HECW2

E3 ubiquitin-protein ligase HECW2 , HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 , E3 ubiquitin-protein ligase HECW2-like , e3 ubiquitin-protein ligase HECW2-like , HECT, C2 and WW domain-containing protein 2 , NEDD4-like E3 ubiquitin-protein ligase 2 , NEDD4-related E3 ubiquitin ligase NEDL2

GENE ID SPEZIES
316395 Rattus norvegicus
424050 Gallus gallus
459844 Pan troglodytes
531691 Bos taurus
100055015 Equus caballus
100331355 Danio rerio
100411186 Callithrix jacchus
100444189 Pongo abelii
100469664 Ailuropoda melanoleuca
100560989 Anolis carolinensis
100602550 Nomascus leucogenys
57520 Homo sapiens
329152 Mus musculus
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