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GUCA2B encodes a member of the guanylin family, and is expressed in the stomach and intestine. Zusätzlich bieten wir Ihnen GUCA2B Kits (20) und GUCA2B Proteine (1) und viele weitere Produktgruppen zu diesem Protein an.
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guanylin (zeige GUCA2A Antikörper) and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage
In obese mice UGN expression was decreased, whereas leptin (zeige LEP Antikörper) treatment up-regulated UGN levels in duodenum in these genetically modified mice compared to WT.
UGN exerts its inhibitory activity on the prendrin gene promoter likely via heat shock factor 1 action at a defined heat shock element site.
findings establish a role for uroguanylin in an enteric-renal communication axis as well as a fundamental principle of this axis in the maintenance of salt homeostasis in vivo
act on the mouse kidney, in part, through a cGMP-dependent, GC-C (zeige GUCY2C Antikörper)-independent mechanism, causing significant natriuresis by renal tubular processes.
existence of two signaling pathways for guanylin (zeige GUCA2A Antikörper) peptides in principal cells of mouse cortical collecting duct of kidney
Role for uroguanylin in fluid homeostasis and as an integral component of a signaling mechanism that mediates changes in Na excretion in response to an enteral salt loading.
Results demonstrate that GC-C (zeige GUCY2C Antikörper) and its ligands, guanylin (zeige GUCA2A Antikörper) and uroguanylin are downregulated in ulcerative colitis (UC), and this downregulation is more significant with aggravation of the clinical condition. Therefore, the GC-C (zeige GUCY2C Antikörper) signaling pathway may be implicated in the progression of UC.
The simulations suggested that all missense SNPs considered as convergent deleterious caused some kind of structural change to the uroguanylin peptide. Additionally, four of these SNPs were also shown to cause modifications in peptide flexibility, possibly resulting in functional changes.
The specific cellular distribution of both GN and UGN differs between duodenum and colon and between human and rat intestines.
Uroguanylin concentrations are increased in patients with chronic renal failure, nephrotic syndrome, or those on dialysis.
This gene encodes a member of the guanylin family, and is expressed in the stomach and intestine. This protein functions as an endogenous ligand for the guanylate cyclase-C receptor and stimulates an increase in cyclic GMP, a key component of several intracellular signal transduction pathways. It maybe involved in salt and water secretion into the intestinal lumen as well as the renal tubules, and thus regulate electrolyte homeostasis in these tissues.
guanylate cyclase activator 2B (uroguanylin)
, guanylate cyclase activator 2B
, guanylate cyclase activator 2b (retina)
, granule cell antiserum positive 2
, guanylyl cyclase activating peptide II