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Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. Zusätzlich bieten wir Ihnen GZMM Antikörper (41) und GZMM Kits (19) und viele weitere Produktgruppen zu diesem Protein an.
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We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain.
Granzym M may be important in regulating HCMV latency and reactivation in SCT patients.
GrM (zeige TPST2 Proteine) is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K (zeige HNRNPK Proteine) in the presence of RNA.
FADD (zeige FADD Proteine) cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase (zeige CASP3 Proteine) cascade.
Results indicate that cellular overexpression of SERPINB4 (zeige SERPINB4 Proteine) inhibits recombinant GrM (zeige TPST2 Proteine)-induced as well as NK cell-mediated cell death.
GrM (zeige TPST2 Proteine) also exists extracellularly in plasma where it could play a physiological role in controlling blood coagulation by determining plasma FVIII (zeige F8 Proteine) levels via proteolytic processing of its carrier VWF (zeige VWF Proteine).
Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes.
Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.
survivin (zeige BIRC5 Proteine) cleavage by Granzyme M triggers degradation of the survivin (zeige BIRC5 Proteine)-X-linked inhibitor of apoptosis protein (XIAP (zeige XIAP Proteine)) complex to free caspase (zeige CASP3 Proteine) activity leading to cytolysis of target tumor cells
These findings support not only a role for GrM (zeige TPST2 Proteine) in the innate but also in the adaptive immune response.
Granzyme M regulates the release of natural killer cell MIP-1alpha (zeige CCL3 Proteine) to initiate innate immune responses.
Natural killer (NK) cell GrzM augments the inflammatory cascade downstream of lipopolysaccharide (LPS (zeige TLR4 Proteine))-toll (zeige TLR4 Proteine)-like receptor (TLR)4 (zeige TLR4 Proteine) signaling, which ultimately results in lethal endotoxicosis.
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.
, Met-1 serine protease
, lymphocyte met-ase 1
, natural killer cell granular protease
, lymphoctye Met-ase 1