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Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. Zusätzlich bieten wir Ihnen GZMM Antikörper (41) und GZMM Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.
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Human GZMM ELISA Kit für Sandwich ELISA - ABIN414663
Bovenschen, Spijkers, Wensink, Schellens, van Domselaar, van Baarle: Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation. in Clinical immunology (Orlando, Fla.) 2014
GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced.
We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain.
Granzym M may be important in regulating HCMV latency and reactivation in SCT patients.
GrM (zeige TPST2 ELISA Kits) is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K (zeige HNRNPK ELISA Kits) in the presence of RNA.
FADD (zeige FADD ELISA Kits) cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase (zeige CASP3 ELISA Kits) cascade.
Results indicate that cellular overexpression of SERPINB4 (zeige SERPINB4 ELISA Kits) inhibits recombinant GrM (zeige TPST2 ELISA Kits)-induced as well as NK cell-mediated cell death.
GrM (zeige TPST2 ELISA Kits) also exists extracellularly in plasma where it could play a physiological role in controlling blood coagulation by determining plasma FVIII (zeige F8 ELISA Kits) levels via proteolytic processing of its carrier VWF (zeige VWF ELISA Kits).
Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes.
Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.
survivin (zeige BIRC5 ELISA Kits) cleavage by Granzyme M triggers degradation of the survivin (zeige BIRC5 ELISA Kits)-X-linked inhibitor of apoptosis protein (XIAP (zeige XIAP ELISA Kits)) complex to free caspase (zeige CASP3 ELISA Kits) activity leading to cytolysis of target tumor cells
Granzyme M regulates the release of natural killer cell MIP-1alpha (zeige CCL3 ELISA Kits) to initiate innate immune responses.
Natural killer (NK) cell GrzM augments the inflammatory cascade downstream of lipopolysaccharide (LPS (zeige TLR4 ELISA Kits))-toll (zeige TLR4 ELISA Kits)-like receptor (TLR)4 (zeige TLR4 ELISA Kits) signaling, which ultimately results in lethal endotoxicosis.
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.
, Met-1 serine protease
, lymphocyte met-ase 1
, natural killer cell granular protease
, lymphoctye Met-ase 1