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Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. Zusätzlich bieten wir Ihnen GZMM Kits (21) und GZMM Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 42 products:
Human Monoclonal GZMM Primary Antibody für ELISA, WB - ABIN516325
Schiffer, Letzian, Jost, Mladenov, Hristodorov, Huhn, Fischer, Barth, Thepen: Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells. in Cancer letters 2013
GzMM has a critical role during early stages of inflammation in ulcerative colitis; in its absence colonic inflammation is enhanced.
We also report that TNFalpha induces the attachment of Met1-linked Ub chains directly to TNF receptor 1, which do not seem to be attached covalently to Lys63-linked or other types of ubiquitin chain.
Granzym M may be important in regulating HCMV latency and reactivation in SCT patients.
GrM (zeige TPST2 Antikörper) is expressed in HCMV-specific CD8thorn T cells and cleaves host cell protein hnRNP K (zeige HNRNPK Antikörper) in the presence of RNA.
FADD (zeige FADD Antikörper) cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase (zeige CASP3 Antikörper) cascade.
Results indicate that cellular overexpression of SERPINB4 (zeige SERPINB4 Antikörper) inhibits recombinant GrM (zeige TPST2 Antikörper)-induced as well as NK cell-mediated cell death.
GrM (zeige TPST2 Antikörper) also exists extracellularly in plasma where it could play a physiological role in controlling blood coagulation by determining plasma FVIII (zeige F8 Antikörper) levels via proteolytic processing of its carrier VWF (zeige VWF Antikörper).
Results describe the structural characterization of granzyme M by molecular modeling as well as by detailed comparison with other granzymes.
Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.
survivin (zeige BIRC5 Antikörper) cleavage by Granzyme M triggers degradation of the survivin (zeige BIRC5 Antikörper)-X-linked inhibitor of apoptosis protein (XIAP (zeige XIAP Antikörper)) complex to free caspase (zeige CASP3 Antikörper) activity leading to cytolysis of target tumor cells
Granzyme M regulates the release of natural killer cell MIP-1alpha (zeige CCL3 Antikörper) to initiate innate immune responses.
Natural killer (NK) cell GrzM augments the inflammatory cascade downstream of lipopolysaccharide (LPS (zeige TLR4 Antikörper))-toll (zeige TLR4 Antikörper)-like receptor (TLR)4 (zeige TLR4 Antikörper) signaling, which ultimately results in lethal endotoxicosis.
Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene.
, Met-1 serine protease
, lymphocyte met-ase 1
, natural killer cell granular protease
, lymphoctye Met-ase 1