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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Zusätzlich bieten wir Ihnen Granulin Antikörper (160) und Granulin Kits (116) und viele weitere Produktgruppen zu diesem Protein an.
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Human Granulin Protein expressed in Wheat germ - ABIN1355792
Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
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Findings show that miR (zeige MYLIP Proteine)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (zeige MYLIP Proteine)-145 in zebrafish embryonic development.
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
Data indicate significant correlation of granulin-epithelin precursor (GEP) with beta-catenin (zeige CTNNB1 Proteine) in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cohort.
We identified 3 novel GRN mutations (p.Q130X, p.317Afs*12, and p.K259Afs*23) in patients diagnosed with nonfluent-variant PPA (zeige PPA1 Proteine) or behavioral-variant FTD (zeige FTL Proteine). The frequency of GRN mutations was 9.6% and that of MAPT (zeige MAPT Proteine) mutations was 7.1%. Among familial cases of FTD (zeige FTL Proteine), the frequency of GRN mutations was 31.5% and that of MAPT (zeige MAPT Proteine) mutations was 10.5% in Brazil.
Missense mutation in GRN gene affecting RNA splicing and plasma progranulin level in a family affected by frontotemporal lobar degeneration.
GRN gene deletion is genetic etiology of familial frontotemporal dementia.
Thisstudy has demonstrated the effect of inflammatory cytokine on cartilage graft as well as the protective role of PGRN on this graft. Without the anti-inflammatory effect from PGRN, hyaline cartilaginous extracellular matrices in living hyaline cartilage graft constructs could be easily remodeled into fibrotic or mineralized tissue and would no longer be able to fulfil the role of a cartilage graft.
This study demonstrated that the GRN mutation carriers showed significant frontoparietal hypoperfusion compared with controls at follow-up.
The GRN risk SNP (rs5848) was associated with variation in detected levels of CSF (zeige CSF2 Proteine) proteins previously implicated in CNS inflammation. The same GRN risk allele was also associated with increased CSF (zeige CSF2 Proteine) tau which may indicate directly related neurodegenerative changes.
Granulin is deposited in specific brain regions that differ between Alzheimer's disease patients and Frontotemporal lobar degeneration patients.
Mutation of GRN is a common cause of FTD (zeige FTL Proteine) in mainland China.
the influence of the p.A152T MAPT (zeige MAPT Proteine) variant on the clinical and neuropathological features of these Basque GRN families, is reported.
highlight an important role for neuron-derived progranulin in maintaining normal social function.
overexpression of PGRN was also found to increase activity of neprilysin (zeige MME Proteine), a key amyloid beta degrading enzyme. PGRN regulation of neprilysin (zeige MME Proteine) activity could play a major role in the observed alterations in plaque burden
PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (zeige GRIN2B Proteine)-contaning NMDA receptors
The PGRN is a nonredundant regulator of systemic inflammation via modulating the levels and activity of C/EBPalpha, IL-10, and the ubiquitin-proteasome proteolysis pathway.
Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration
PGRN induction of IL-10 (zeige IL10 Proteine) in Treg cells depends on FOXO4 (zeige FOXO4 Proteine) and Stat3 (zeige STAT3 Proteine).
ECM1 (zeige ECM1 Proteine) seems to be critical for PTHrP action in chondrogenesis, as blockage of ECM1 (zeige ECM1 Proteine) nearly abolishes PTHrP regulation of chondrocyte hypertrophy, and overexpression of ECM1 (zeige ECM1 Proteine) rescues disorganized growth plates of PTHrP-null mice; ECM1 (zeige ECM1 Proteine) and progranulin chondrogenic growth factor constitute an interaction network.
Knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1 (zeige RIPK1 Proteine)) increased both intracellular and extracellular PGRN protein levels by increasing the translation rate of PGRN without affecting mRNA levels.
In progranulin knockout mice, there was no estrogen receptor alpha (zeige ESR1 Proteine) immunoreactivity in astrocytes in males or females at various ages. These results suggest that PGRN plays a crucial role in the expression of ERalpha (zeige ESR1 Proteine) in astrocytes regardless of the estrous cycle stage, sex, and maturity.
recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis.
ADAM15 (zeige ADAM15 Proteine) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
, PC cell-derived growth factor