Granulin Proteine (GRN)

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Zusätzlich bieten wir Ihnen Granulin Antikörper (159) und Granulin Kits (108) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Showing 10 out of 45 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_HEK-293 Cells Ratte DYKDDDDK Tag 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
942,86 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
HOST_HEK-293 Cells Maus DYKDDDDK Tag 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
942,86 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_HEK-293 Cells Maus Unkonjugiert 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
995,24 €
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HOST_HEK-293 Cells Ratte Unkonjugiert 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
995,24 €
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HOST_HEK-293 Cells Human Unkonjugiert 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
995,24 €
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HOST_Escherichia coli (E. coli) Human His tag,S tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
426,67 €
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HOST_Human Cells Human His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
Details

GRN Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
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Rat (Rattus) ,
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Mouse (Murine) , , ,
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Am meisten referenzierte Granulin Proteine

  1. Human Granulin Protein expressed in Wheat germ - ABIN1355792 : Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 (PubMed)
    Zeige alle 3 Referenzen für 1355792

Weitere Proteine zu Granulin (GRN) Interaktionspartnern

Zebrafish Granulin (GRN) Interaktionspartner

  1. Findings show that miR (zeige MYLIP Proteine)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (zeige MYLIP Proteine)-145 in zebrafish embryonic development.

  2. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  3. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) Interaktionspartner

  1. Mutation of GRN is a common cause of FTD (zeige FTL Proteine) in mainland China.

  2. the influence of the p.A152T MAPT (zeige MAPT Proteine) variant on the clinical and neuropathological features of these Basque GRN families, is reported.

  3. Results indicate that central nervous progranulin reduction is not restricted to the relatively rare cases of frontotemporal dementia caused by progranulin gene (GRN) loss of function mutations, but also contributes to the more common GRN-negative forms of frontotemporal dementia.

  4. a complete screening for mutations in MAPT (zeige MAPT Proteine), GRN and C9ORF72 (zeige C9ORF72 Proteine) genes revealed a frequency of 5.4% of pathogenic mutations in a random cohort of 93 Turkish index patients with dementia

  5. This Progress article reviews recent advances in progranulin biology emphasizing its roles in lysosomal function and brain innate immunity, and outlines future avenues of investigation that may lead to new therapeutic approaches for neurodegeneration--{REVIEW}

  6. serum progranulin levels had a positive correlation with pulmonary function in patients with asthma and a negative correlation with blood neutrophil counts.

  7. Progranulin (PGRN), a 593-amino-acid autocrine growth factor has multiple functions involved in cell proliferation, wound healing, neurodegeneration, insulin (zeige INS Proteine) resistance, and tumorigenesis.

  8. progranulin is affected by a decrease in eGFR (zeige EGFR Proteine), being at a higher concentration in serum and lower in urine of DKD patients with T2DM and eGFR (zeige EGFR Proteine) <60 mL/min/1.73m2. It is also associated with markers of obesity and inflammation

  9. EphA2 (zeige EPHA2 Proteine), a member of the large family of Ephrin receptor tyrosine kinases, is a functional signaling receptor for progranulin.

  10. recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis

Mouse (Murine) Granulin (GRN) Interaktionspartner

  1. PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (zeige GRIN2B Proteine)-contaning NMDA receptors

  2. The PGRN is a nonredundant regulator of systemic inflammation via modulating the levels and activity of C/EBPalpha, IL-10, and the ubiquitin-proteasome proteolysis pathway.

  3. Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration

  4. PGRN induction of IL-10 (zeige IL10 Proteine) in Treg cells depends on FOXO4 (zeige FOXO4 Proteine) and Stat3 (zeige STAT3 Proteine).

  5. ECM1 (zeige ECM1 Proteine) seems to be critical for PTHrP action in chondrogenesis, as blockage of ECM1 (zeige ECM1 Proteine) nearly abolishes PTHrP regulation of chondrocyte hypertrophy, and overexpression of ECM1 (zeige ECM1 Proteine) rescues disorganized growth plates of PTHrP-null mice; ECM1 (zeige ECM1 Proteine) and progranulin chondrogenic growth factor constitute an interaction network.

  6. Knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1 (zeige RIPK1 Proteine)) increased both intracellular and extracellular PGRN protein levels by increasing the translation rate of PGRN without affecting mRNA levels.

  7. In progranulin knockout mice, there was no estrogen receptor alpha (zeige ESR1 Proteine) immunoreactivity in astrocytes in males or females at various ages. These results suggest that PGRN plays a crucial role in the expression of ERalpha (zeige ESR1 Proteine) in astrocytes regardless of the estrous cycle stage, sex, and maturity.

  8. recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis.

  9. Progranulin causes adipose insulin (zeige INS Proteine) resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress.

  10. Grn+/- mice have biphasic social dominance associated with abnormal neuronal morphology and signaling. Grn-/- mice did not exhibit abnormal social dominance.

Guinea Pig Granulin (GRN) Interaktionspartner

  1. ADAM15 (zeige ADAM15 Proteine) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Protein Überblick

Protein Überblick

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Genbezeichner und Symbole assoziert mit Granulin Proteine (GRN)

  • granulin (GRN)
  • granulin a (grna)
  • Granulins (grn)
  • granulin (grn)
  • granulin (granulin)
  • granulin (ORF1 granulin)
  • granulin (Grn)
  • acrogranin Protein
  • CLN11 Protein
  • DKFZp459H066 Protein
  • epithelin Protein
  • GEP Protein
  • GP88 Protein
  • grn Protein
  • MGC53354 Protein
  • PCDGF Protein
  • PEPI Protein
  • PGRN Protein
  • wu:fb11g12 Protein
  • wu:fj18f05 Protein

Bezeichner auf Proteinebene für Granulin Proteine (GRN)

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPEZIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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