Granulin Proteine (GRN)

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Zusätzlich bieten wir Ihnen Granulin Antikörper (160) und Granulin Kits (116) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Showing 10 out of 43 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HEK-293 Cells Ratte DYKDDDDK Tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$765.00
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
HEK-293 Cells Ratte Unkonjugiert 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$810.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
HEK-293 Cells Maus DYKDDDDK Tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$765.00
Details
Hefe REACT_Agrotis segetum granulosis virus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,632.67
Details
Hefe REACT_Cydia pomonella granulosis virus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,634.50
Details
Hefe REACT_Xestia c-nigrum granulosis virus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,634.50
Details
HEK-293 Cells Maus Unkonjugiert 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$810.00
Details

GRN Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
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Rat (Rattus) ,
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Mouse (Murine) , , ,
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Am meisten referenzierte Granulin Proteine

  1. Human Granulin Protein expressed in Wheat germ - ABIN1355792 : Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 (PubMed)
    Show all 3 Pubmed References

Weitere Proteine zu Granulin (GRN) Interaktionspartnern

Zebrafish Granulin (GRN) Interaktionspartner

  1. Findings show that miR (zeige MYLIP Proteine)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (zeige MYLIP Proteine)-145 in zebrafish embryonic development.

  2. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  3. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) Interaktionspartner

  1. Data indicate significant correlation of granulin-epithelin precursor (GEP) with beta-catenin (zeige CTNNB1 Proteine) in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cohort.

  2. We identified 3 novel GRN mutations (p.Q130X, p.317Afs*12, and p.K259Afs*23) in patients diagnosed with nonfluent-variant PPA (zeige PPA1 Proteine) or behavioral-variant FTD (zeige FTL Proteine). The frequency of GRN mutations was 9.6% and that of MAPT (zeige MAPT Proteine) mutations was 7.1%. Among familial cases of FTD (zeige FTL Proteine), the frequency of GRN mutations was 31.5% and that of MAPT (zeige MAPT Proteine) mutations was 10.5% in Brazil.

  3. Missense mutation in GRN gene affecting RNA splicing and plasma progranulin level in a family affected by frontotemporal lobar degeneration.

  4. GRN gene deletion is genetic etiology of familial frontotemporal dementia.

  5. Thisstudy has demonstrated the effect of inflammatory cytokine on cartilage graft as well as the protective role of PGRN on this graft. Without the anti-inflammatory effect from PGRN, hyaline cartilaginous extracellular matrices in living hyaline cartilage graft constructs could be easily remodeled into fibrotic or mineralized tissue and would no longer be able to fulfil the role of a cartilage graft.

  6. This study demonstrated that the GRN mutation carriers showed significant frontoparietal hypoperfusion compared with controls at follow-up.

  7. The GRN risk SNP (rs5848) was associated with variation in detected levels of CSF (zeige CSF2 Proteine) proteins previously implicated in CNS inflammation. The same GRN risk allele was also associated with increased CSF (zeige CSF2 Proteine) tau which may indicate directly related neurodegenerative changes.

  8. Granulin is deposited in specific brain regions that differ between Alzheimer's disease patients and Frontotemporal lobar degeneration patients.

  9. Mutation of GRN is a common cause of FTD (zeige FTL Proteine) in mainland China.

  10. the influence of the p.A152T MAPT (zeige MAPT Proteine) variant on the clinical and neuropathological features of these Basque GRN families, is reported.

Mouse (Murine) Granulin (GRN) Interaktionspartner

  1. highlight an important role for neuron-derived progranulin in maintaining normal social function.

  2. overexpression of PGRN was also found to increase activity of neprilysin (zeige MME Proteine), a key amyloid beta degrading enzyme. PGRN regulation of neprilysin (zeige MME Proteine) activity could play a major role in the observed alterations in plaque burden

  3. PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (zeige GRIN2B Proteine)-contaning NMDA receptors

  4. The PGRN is a nonredundant regulator of systemic inflammation via modulating the levels and activity of C/EBPalpha, IL-10, and the ubiquitin-proteasome proteolysis pathway.

  5. Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration

  6. PGRN induction of IL-10 (zeige IL10 Proteine) in Treg cells depends on FOXO4 (zeige FOXO4 Proteine) and Stat3 (zeige STAT3 Proteine).

  7. ECM1 (zeige ECM1 Proteine) seems to be critical for PTHrP action in chondrogenesis, as blockage of ECM1 (zeige ECM1 Proteine) nearly abolishes PTHrP regulation of chondrocyte hypertrophy, and overexpression of ECM1 (zeige ECM1 Proteine) rescues disorganized growth plates of PTHrP-null mice; ECM1 (zeige ECM1 Proteine) and progranulin chondrogenic growth factor constitute an interaction network.

  8. Knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1 (zeige RIPK1 Proteine)) increased both intracellular and extracellular PGRN protein levels by increasing the translation rate of PGRN without affecting mRNA levels.

  9. In progranulin knockout mice, there was no estrogen receptor alpha (zeige ESR1 Proteine) immunoreactivity in astrocytes in males or females at various ages. These results suggest that PGRN plays a crucial role in the expression of ERalpha (zeige ESR1 Proteine) in astrocytes regardless of the estrous cycle stage, sex, and maturity.

  10. recruitment of granulin-expressing inflammatory monocytes plays a key role in Pancreatic ductal adenocarcinoma metastasis.

Guinea Pig Granulin (GRN) Interaktionspartner

  1. ADAM15 (zeige ADAM15 Proteine) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Protein Überblick

Protein Überblick

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Genbezeichner und Symbole assoziert mit Granulin Proteine (GRN)

  • granulin precursor (GRN)
  • granulin a (grna)
  • Granulins (grn)
  • granulin L homeolog (grn.L)
  • granulin (granulin)
  • granulin (ORF1 granulin)
  • granulin precursor (Grn)
  • granulin (Grn)
  • acrogranin Protein
  • CLN11 Protein
  • DKFZp459H066 Protein
  • epithelin Protein
  • GEP Protein
  • GP88 Protein
  • grn Protein
  • MGC53354 Protein
  • PCDGF Protein
  • PEPI Protein
  • PGRN Protein
  • wu:fb11g12 Protein
  • wu:fj18f05 Protein

Bezeichner auf Proteinebene für Granulin Proteine (GRN)

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPEZIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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