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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Zusätzlich bieten wir Ihnen Granulin Antikörper (162) und Granulin Proteine (43) und viele weitere Produktgruppen zu diesem Protein an.
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Human Granulin ELISA Kit für Sandwich ELISA - ABIN578626
Qu, Deng, Hu: Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance. in Mediators of inflammation 2013
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Rat (Rattus) Granulin ELISA Kit für Sandwich ELISA - ABIN4881274
Zhou, Xie, Wang, Zhang, Chen, Zhang, Wu, Wei, Ding, Hang, Zhou, Shi: Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment. in Journal of neuroinflammation 2015
Findings show that miR (zeige MYLIP ELISA Kits)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (zeige MYLIP ELISA Kits)-145 in zebrafish embryonic development.
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models
results revealed an important role of NF-kappaB (zeige NFKB1 ELISA Kits) signalling in PGRN-associated frontotemporal lobar degeneration-DNA-binding protein (zeige UBE2V1 ELISA Kits) 43 and confirm that PGRN can bind to TNF-alpha (zeige TNF ELISA Kits) receptors regulating the expression of WNT5A (zeige WNT5A ELISA Kits), suggesting novel targets for treatment of frontotemporal lobar degeneration-DNA-binding protein (zeige UBE2V1 ELISA Kits) linked to GRN mutations.
These results suggest an important role of Wnt (zeige WNT2 ELISA Kits) activation inducing cell cycle disturbance-mediated neuronal loss in the pathogenesis of PGRN deficiency-linked frontotemporal lobar degeneration with TDP-43 (zeige TARDBP ELISA Kits) protein inclusions.
Study demonstrate that PGRN interacts with the lysosomal protease CTSD (zeige CTSD ELISA Kits) and maintains its proper activity in vivo. Therefore, by regulating CTSD (zeige CTSD ELISA Kits) activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 (zeige TARDBP ELISA Kits) aggregation observed in frontotemporal lobar degeneration with GRN mutations.
Data indicate significant correlation of granulin-epithelin precursor (GEP (zeige GNA12 ELISA Kits)) with beta-catenin (zeige CTNNB1 ELISA Kits) in hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) cohort.
We identified 3 novel GRN mutations (p.Q130X, p.317Afs*12, and p.K259Afs*23) in patients diagnosed with nonfluent-variant PPA (zeige PPA1 ELISA Kits) or behavioral-variant FTD (zeige FTL ELISA Kits). The frequency of GRN mutations was 9.6% and that of MAPT (zeige MAPT ELISA Kits) mutations was 7.1%. Among familial cases of FTD (zeige FTL ELISA Kits), the frequency of GRN mutations was 31.5% and that of MAPT (zeige MAPT ELISA Kits) mutations was 10.5% in Brazil.
Missense mutation in GRN gene affecting RNA splicing and plasma progranulin level in a family affected by frontotemporal lobar degeneration.
GRN gene deletion is genetic etiology of familial frontotemporal dementia.
Thisstudy has demonstrated the effect of inflammatory cytokine on cartilage graft as well as the protective role of PGRN on this graft. Without the anti-inflammatory effect from PGRN, hyaline cartilaginous extracellular matrices in living hyaline cartilage graft constructs could be easily remodeled into fibrotic or mineralized tissue and would no longer be able to fulfil the role of a cartilage graft.
This study demonstrated that the GRN mutation carriers showed significant frontoparietal hypoperfusion compared with controls at follow-up.
The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.
Findings suggest that elevated PGRN is linked to cognitive deficits of fragile X (zeige FMR1 ELISA Kits) syndrome.
highlight an important role for neuron-derived progranulin in maintaining normal social function.
overexpression of PGRN was also found to increase activity of neprilysin (zeige MME ELISA Kits), a key amyloid beta degrading enzyme. PGRN regulation of neprilysin (zeige MME ELISA Kits) activity could play a major role in the observed alterations in plaque burden
PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (zeige GRIN2B ELISA Kits)-contaning NMDA receptors
The PGRN is a nonredundant regulator of systemic inflammation via modulating the levels and activity of C/EBPalpha, IL-10, and the ubiquitin-proteasome proteolysis pathway.
Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration
PGRN induction of IL-10 (zeige IL10 ELISA Kits) in Treg cells depends on FOXO4 (zeige FOXO4 ELISA Kits) and Stat3 (zeige STAT3 ELISA Kits).
ADAM15 (zeige ADAM15 ELISA Kits) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
, PC cell-derived growth factor