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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Zusätzlich bieten wir Ihnen Granulin Kits (116) und Granulin Proteine (43) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 162 products:
Human Polyclonal Granulin Primary Antibody für WB - ABIN1881391
Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992
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Human Monoclonal Granulin Primary Antibody für ELISA, WB - ABIN966227
Lu, Serrero: Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. in Biochemical and biophysical research communications 1999
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Human Monoclonal Granulin Primary Antibody für IP, IHC - ABIN1169394
Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008
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Human Polyclonal Granulin Primary Antibody für ELISA, WB - ABIN439720
Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008
Human Polyclonal Granulin Primary Antibody für IF (p), IHC (p) - ABIN728668
Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015
Human Polyclonal Granulin Primary Antibody für ICC, IF - ABIN4315995
Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011
Human Polyclonal Granulin Primary Antibody für ICC, IF - ABIN4315998
Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011
Human Polyclonal Granulin Primary Antibody für ELISA, WB - ABIN561132
Bandey, Chiou, Huang, Tsai, Tu: Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. in Oncogene 2015
Findings show that miR (zeige MYLIP Antikörper)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (zeige MYLIP Antikörper)-145 in zebrafish embryonic development.
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
results revealed an important role of NF-kappaB (zeige NFKB1 Antikörper) signalling in PGRN-associated frontotemporal lobar degeneration-DNA-binding protein (zeige UBE2V1 Antikörper) 43 and confirm that PGRN can bind to TNF-alpha (zeige TNF Antikörper) receptors regulating the expression of WNT5A (zeige WNT5A Antikörper), suggesting novel targets for treatment of frontotemporal lobar degeneration-DNA-binding protein (zeige UBE2V1 Antikörper) linked to GRN mutations.
These results suggest an important role of Wnt (zeige WNT2 Antikörper) activation inducing cell cycle disturbance-mediated neuronal loss in the pathogenesis of PGRN deficiency-linked frontotemporal lobar degeneration with TDP-43 (zeige TARDBP Antikörper) protein inclusions.
Study demonstrate that PGRN interacts with the lysosomal protease CTSD (zeige CTSD Antikörper) and maintains its proper activity in vivo. Therefore, by regulating CTSD (zeige CTSD Antikörper) activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 (zeige TARDBP Antikörper) aggregation observed in frontotemporal lobar degeneration with GRN mutations.
Data indicate significant correlation of granulin-epithelin precursor (GEP (zeige GNA12 Antikörper)) with beta-catenin (zeige CTNNB1 Antikörper) in hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) cohort.
We identified 3 novel GRN mutations (p.Q130X, p.317Afs*12, and p.K259Afs*23) in patients diagnosed with nonfluent-variant PPA (zeige PPA1 Antikörper) or behavioral-variant FTD (zeige FTL Antikörper). The frequency of GRN mutations was 9.6% and that of MAPT (zeige MAPT Antikörper) mutations was 7.1%. Among familial cases of FTD (zeige FTL Antikörper), the frequency of GRN mutations was 31.5% and that of MAPT (zeige MAPT Antikörper) mutations was 10.5% in Brazil.
Missense mutation in GRN gene affecting RNA splicing and plasma progranulin level in a family affected by frontotemporal lobar degeneration.
GRN gene deletion is genetic etiology of familial frontotemporal dementia.
Thisstudy has demonstrated the effect of inflammatory cytokine on cartilage graft as well as the protective role of PGRN on this graft. Without the anti-inflammatory effect from PGRN, hyaline cartilaginous extracellular matrices in living hyaline cartilage graft constructs could be easily remodeled into fibrotic or mineralized tissue and would no longer be able to fulfil the role of a cartilage graft.
This study demonstrated that the GRN mutation carriers showed significant frontoparietal hypoperfusion compared with controls at follow-up.
The GRN risk SNP (rs5848) was associated with variation in detected levels of CSF (zeige CSF2 Antikörper) proteins previously implicated in CNS inflammation. The same GRN risk allele was also associated with increased CSF (zeige CSF2 Antikörper) tau which may indicate directly related neurodegenerative changes.
Findings suggest that elevated PGRN is linked to cognitive deficits of fragile X (zeige FMR1 Antikörper) syndrome.
highlight an important role for neuron-derived progranulin in maintaining normal social function.
overexpression of PGRN was also found to increase activity of neprilysin (zeige MME Antikörper), a key amyloid beta degrading enzyme. PGRN regulation of neprilysin (zeige MME Antikörper) activity could play a major role in the observed alterations in plaque burden
PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (zeige GRIN2B Antikörper)-contaning NMDA receptors
The PGRN is a nonredundant regulator of systemic inflammation via modulating the levels and activity of C/EBPalpha, IL-10, and the ubiquitin-proteasome proteolysis pathway.
Grn and Tmem106b genes have opposite effects on lysosomal enzyme levels, and their interaction determines the extent of neurodegeneration
PGRN induction of IL-10 (zeige IL10 Antikörper) in Treg cells depends on FOXO4 (zeige FOXO4 Antikörper) and Stat3 (zeige STAT3 Antikörper).
ECM1 (zeige ECM1 Antikörper) seems to be critical for PTHrP (zeige PTHLH Antikörper) action in chondrogenesis, as blockage of ECM1 (zeige ECM1 Antikörper) nearly abolishes PTHrP (zeige PTHLH Antikörper) regulation of chondrocyte hypertrophy, and overexpression of ECM1 (zeige ECM1 Antikörper) rescues disorganized growth plates of PTHrP (zeige PTHLH Antikörper)-null mice; ECM1 (zeige ECM1 Antikörper) and progranulin chondrogenic growth factor constitute an interaction network.
Knocking down receptor-interacting serine/threonine protein kinase 1 (Ripk1 (zeige RIPK1 Antikörper)) increased both intracellular and extracellular PGRN protein levels by increasing the translation rate of PGRN without affecting mRNA levels.
ADAM15 (zeige ADAM15 Antikörper) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
, PC cell-derived growth factor