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The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. Zusätzlich bieten wir Ihnen Golgi Membrane Protein 1 Antikörper (169) und Golgi Membrane Protein 1 Kits (37) und viele weitere Produktgruppen zu diesem Protein an.
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Human GOLM1 Protein expressed in Human Cells - ABIN2005402
Kladney, Bulla, Guo, Mason, Tollefson, Simon, Koutoubi, Fimmel: GP73, a novel Golgi-localized protein upregulated by viral infection. in Gene 2000
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Human GOLM1 Protein expressed in Escherichia coli (E. coli) - ABIN2005400
Kladney, Tollefson, Wold, Fimmel: Upregulation of the Golgi protein GP73 by adenovirus infection requires the E1A CtBP interaction domain. in Virology 2002
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Both gain- and loss-of-function studies determine that GOLM1 acts as a key oncogene (zeige RAB1A Proteine) by promoting HCC (zeige FAM126A Proteine) growth and metastasis.
A cytokine QTL at the NAA35 (zeige MAK10 Proteine)-GOLM1 locus markedly modulated interleukin (IL)-6 (zeige IL6 Proteine) production in response to multiple pathogens and was associated with susceptibility to candidemia.
knock-down of GP73 down-regulates HCV infection and replication in Huh7-MAVSR cells and primary human hepatocytes
Studies indicate that golgi membrane protein 1 (GOLM1) may promote HCC (zeige FAM126A Proteine) by regulation of epidermal growth factor receptor (EGFR (zeige EGFR Proteine)) recycling, and suggest that therapeutic targeting of GOLM1 may be a potential strategy for combating hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) metastasis.
these studies revealed that GP73 promotes hepatitis C virus (HCV) secretion by directly mediating the interaction of ApoE (zeige APOE Proteine) with HCV replication complex through binding with HCV NS5A.
Significantly higher serum levels of GP-73 and PIVKA-II were detected in the hepatocellular carcinoma patients than in controls.
The critical role of GP73 in hepatocellular carcinoma invasion, epithelial-mesenchymal transition and metastasis
Results show that overexpression of GP73 in hepatocellular carcinoma cell (HCC (zeige FAM126A Proteine)) line retrieved the expression of epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) markers, and promoted cell motility and invasion. High expression of GP73 was also found in HCC (zeige FAM126A Proteine) tissues with metastasis providing evidence for an important role of GP73 in HCC (zeige FAM126A Proteine) metastasis.
Serum GP73 had limited diagnostic value for HBV-related liver cancer. The combined use of serum GP73 and AFP (zeige AFP Proteine) levels improved the diagnostic efficacy.
GP73 enhances MMP-13 (zeige MMP13 Proteine) expression through cAMP responsive element binding protein (CREB (zeige CREB1 Proteine))-mediated transcription activation. Levels of GP73 and MMP-13 (zeige MMP13 Proteine) are increased and positively correlated in human HCC (zeige FAM126A Proteine) tissues. Augmented MMP-13 (zeige MMP13 Proteine) potentiates HCC (zeige FAM126A Proteine) cell metastasis.
Gorasp2-/- mice suffered from spermatogenesis defects. Golgi morphology of spermatocytes was disturbed in Gorasp2-/- mice. GRASP55 interacted via PDZ-mediated interactions with JAMs.
GRASP55 (zeige GORASP2 Proteine) responds to inflammasome stimulation,controls autophagy initiation and important for secretion of IL-1b (zeige IL1B Proteine) and IL-18 (zeige IL18 Proteine)
In Atp7b (zeige ATP7B Proteine)(-/-) mice, GP73 mRNA was significantly elevated at 20-46 weeks of age, coincident with extensive hepatic inflammation and fibrosis.
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene.
golgi membrane protein 1
, golgi phosphoprotein 2
, Golgi membrane protein 1
, golgi membrane protein GP73
, golgi protein, 73-kD
, Golgi reassembly-stacking protein 2
, golgi reassembly-stacking protein of 55 kDa