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Glycoprotein Ib (Platelet), alpha Polypeptide Proteine (GP1BA)

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. Zusätzlich bieten wir Ihnen Glycoprotein Ib (Platelet), alpha Polypeptide Antikörper (198) und Glycoprotein Ib (Platelet), alpha Polypeptide Kits (13) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte GP1BA GP1BA 691992  
GP1BA 14723 O35930
GP1BA 2811  
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Top Glycoprotein Ib (Platelet), alpha Polypeptide Proteine auf antikoerper-online.de

Showing 8 out of 17 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 56 bis 61 Tage
5.753,97 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 15 bis 16 Tage
324,76 €
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Hefe Human His tag   50 μg Anmelden zum Anzeigen 12 bis 16 Tage
324,76 €
Details
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
664,76 €
Details
HOST_Escherichia coli (E. coli) Maus S tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
695,24 €
Details

GP1BA Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
, ,
Human , , ,
, , ,

Weitere Proteine zu Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) Interaktionspartnern

Cow (Bovine) Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) Interaktionspartner

  1. both the gpIb-VWF (zeige VWF Proteine) interaction and the integrin alpha(2 (zeige ITGA2 Proteine))beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (zeige GSTA3 Proteine))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF (zeige VWF Proteine) is bound

Mouse (Murine) Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) Interaktionspartner

  1. allosteric inhibitor SbO4L targets the glycoprotein Ibalpha-binding and heparin-binding site of thrombin (zeige F2 Proteine)

  2. Thrombin (zeige F2 Proteine) cleavage of platelet PAR4 (zeige F2RL3 Proteine) promotes leukocyte recruitment to sites of vascular injury. This process is negatively regulated by GPIbalpha.

  3. GPIbalpha-mediated interactions between platelets and endothelial cells, as well as leukocytes, support innate immune cell recruitment and promote arteriogenesis-establishing platelets as critical players in this process.

  4. Atherosclerosis reduction in mice lacking GPIbalpha may not result from the defective GPIbalpha-ligand binding, but more likely is a consequence of functional defects of GPIbalpha-/- platelets and reduced blood platelet counts.

  5. Data suggest that targeting platelet receptor glycoprotein Ibalpha (GPIbalpha)-von Willebrand factor VWF (zeige VWF Proteine)-A1 binding interface may offer a therapeutic approach to reducing platelet-driven thrombosis.

  6. Following endothelial damage, platelet cross-linking during closure of the vessel lumen is mediated by GPIbalpha-VWF (zeige VWF Proteine) interactions.

  7. Platelet IKKbeta (zeige IKBKB Proteine) deficiency increases the formation of injury-induced arterial neointimal tissue via delayed glycoprotein Ibalpha shedding.

  8. these data demonstrate that coordinated expression of GPIbalpha and filamin (zeige FLNA Proteine) is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets.

  9. Desialylation of platelet VWFR therefore triggers platelet clearance and primes GPIbalpha and GPV for MP-dependent cleavage.

  10. miscarriage occurred in the majority of pregnancies in a model of anti-GPIbalpha-mediated fetal and neonatal immune thrombocytopenia (FNIT), which was far more frequent than in anti-integrinbeta3-mediated FNIT

Human Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) Interaktionspartner

  1. Our results suggest that the -5CC genotype in Kozak sequence of GPIb-alpha may be associated with a higher risk of developing arterial ischemia of lower limbs in type 2 diabetes mellitus patients.

  2. Specific inhibition of GPIbalpha shedding in the stored platelets improves post-transfusion platelet recovery and hemostatic function, providing clear evidence for GPIbalpha shedding as a cause of platelet clearance.

  3. miR (zeige MLXIP Proteine)-10a and miR10b regulate the expression of human platelet GP1BA and GP1bb (zeige GP1BB Proteine) for normal megakaryopoiesis.

  4. Data indicate that binding of hemoblobin (Hb) to glycoprotein1balpha (GP1balpha) induced platelet activation plays a crucial role in thrombus formation on immobilized von Willebrand factor (VWF (zeige VWF Proteine)) or type I collagen under shear stresses.

  5. allosteric inhibitor SbO4L targets the glycoprotein Ibalpha-binding and heparin-binding site of thrombin (zeige F2 Proteine)

  6. Lateral dimerization of GPIbalpha induced by antibody binding is not sufficient to initiate GPIb-IX signaling and induce platelet clearance.

  7. GPIb alpha plays a critical role in the co-localization of thrombin (zeige F2 Proteine) and factor XI and the resultant efficient activation of FXI (zeige F11 Proteine)

  8. Hemoglobin interaction with GP1balpha induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis.

  9. Both GPIbalpha and PAR4 (zeige PAWR Proteine) are required for thrombin (zeige F2 Proteine)-induced reactive oxygen species formation

  10. Report no relationship, between polymorphisms of platelet membrane glycoprotein Ibalpha and risk of coronary heart disease in Chinese Han population.

Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA) Protein Überblick

Protein Überblick

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Genbezeichner und Symbole assoziert mit GP1BA

  • glycoprotein Ib (platelet), alpha polypeptide (Gp1ba)
  • glycoprotein Ib (platelet), alpha polypeptide (GP1BA)
  • glycoprotein 1b, alpha polypeptide (Gp1ba)
  • BDPLT1 Protein
  • BDPLT3 Protein
  • BSS Protein
  • CD42B Protein
  • CD42b-alpha Protein
  • DBPLT3 Protein
  • GP1B Protein
  • GP1BA Protein
  • GPIbA Protein
  • GPIbalpha Protein
  • VWDP Protein

Bezeichner auf Proteinebene für GP1BA

glycoprotein 1b, alpha polypeptide , platelet glycoprotein Ib alpha chain , glycoprotein Ib (platelet), alpha polypeptide , platelet glycoprotein Ib alpha polypeptide , GP-Ib alpha , glycoprotein Ibalpha , antigen CD42b-alpha , platelet membrane glycoprotein 1b-alpha subunit , GPIb-alpha , GPIbA

GENE ID SPEZIES
691992 Rattus norvegicus
420059 Gallus gallus
468166 Pan troglodytes
504977 Bos taurus
14723 Mus musculus
2811 Homo sapiens
403638 Canis lupus familiaris
Ausgewählte Anbieter für Glycoprotein Ib (Platelet), alpha Polypeptide Proteine (GP1BA)
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