anti-GTP Cyclohydrolase 1 (GCH1) Antikörper

GCH1 encodes a member of the GTP cyclohydrolase family. Zusätzlich bieten wir Ihnen GTP Cyclohydrolase 1 Proteine (12) und GTP Cyclohydrolase 1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GCH1 2643 P30793
GCH1 14528 Q05915
GCH1 29244 P22288
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Top anti-GTP Cyclohydrolase 1 Antikörper auf antikoerper-online.de

Showing 10 out of 91 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-GCH1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: COLO205 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host: Rabbit Target Name: GCH1 Sample Tissue: Human Fetal Heart Antibody Dilution: 1ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IP, IHC, ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 6 Tage
$327.00
Details
Human Maus Unkonjugiert WB GCH1 monoclonal antibody (M01), clone 4A12 Western Blot analysis of GCH1 expression in IMR-32 on formalin-fixed paraffin-embedded human lymph node (antibody concentration 3 µg/mL). 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Maus Unkonjugiert ELISA Detection limit for recombinant GST tagged GCH1 is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Ziege Unkonjugiert ELISA, WB Western Blot: GCH1 Antibody [NBP1-20923] - (0.5ug/ml) staining of Human Tonsil lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$408.19
Details
Fledermaus Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$610.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB GCH1 Antibody (N-term) (ABIN652021) western blot analysis in ZR-75-1 cell line lysates (35 µg/lane). This demonstrates the GCH1 antibody detected the GCH1 protein (arrow). GCH1 Antibody (N-term) (ABIN652021) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Maus Unkonjugiert IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to GCH1 on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 3 ug/ml] GCH1 monoclonal antibody (M01), clone 4A12 Western Blot analysis of GCH1 expression in IMR-32 . 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$430.00
Details

GCH1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-GTP Cyclohydrolase 1 Antikörper

  1. Human Monoclonal GCH1 Primary Antibody für IHC (p), IP - ABIN561018 : Widder, Chen, Li, Dikalov, Thöny, Hatakeyama, Harrison: Regulation of tetrahydrobiopterin biosynthesis by shear stress. in Circulation research 2007 (PubMed)
    Show all 11 Pubmed References

  2. Human Polyclonal GCH1 Primary Antibody für ELISA, WB - ABIN451682 : Tegeder, Costigan, Griffin, Abele, Belfer, Schmidt, Ehnert, Nejim, Marian, Scholz, Wu, Allchorne, Diatchenko, Binshtok, Goldman, Adolph, Sama, Atlas, Carlezon, Parsegian, Lötsch, Fillingim, Maixner et al.: GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. ... in Nature medicine 2006 (PubMed)

  3. Human Polyclonal GCH1 Primary Antibody für IP, IHC - ABIN1584545 : Meng, Liang, Li, Chen, Liu, Li: Changes of GTP cyclohydrolase I and neuronal apoptosis in rat spinal dorsal cord induced by sciatic nerve injury. in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2013 (PubMed)

Weitere Antikörper gegen GTP Cyclohydrolase 1 Interaktionspartner

Human GTP Cyclohydrolase 1 (GCH1) Interaktionspartner

  1. GCH1 variants affect early PD risk through altered dopamine uptake, and aging alters how genetic factors contribute to disease development.

  2. This study demonstrated that whole-exome sequencing show reveled GCH1 mutation with early-onset generalized dystonia.

  3. Deletion of GCH1 likely contributes to dopa-responsive dystonia.

  4. High GCH1 expression is associated with esophageal squamous cell carcinoma.

  5. Dopa-responsive dystonia phenotype may have heterogeneous genetic background and may be caused by point mutations or rearrangements in the GCH1 gene as well as in the PARK2 (zeige PARK2 Antikörper) gene.

  6. This study found that rs11158026 (GCH1) is associated with Parkinson disease in Iran population.

  7. No association between the GCH1 pain-protective haplotype and cervical dilation was found, but a previously demonstrated association with increased use of second-line analgesia was confirmed.

  8. GTPCH/Ang-1 (zeige ANGPT1 Antikörper) interaction in stromal fibroblasts and activation of Tie2 (zeige TEK Antikörper) on breast tumor cells could play an important role in supporting breast cancer growth. GTPCH may be an important mechanism of paracrine tumor growth and hence a target for therapy in breast cancer.

  9. suggest that the GCH1 and MIR4697 but not SIPA1L2 and VPS13C (zeige vps13c Antikörper) are genetic loci influencing risk of Parkinson's disease in Taiwan

  10. The risk of orofacial clefts is associated with variants of the GCH1 gene related to BH4 metabolism.

Mouse (Murine) GTP Cyclohydrolase 1 (GCH1) Interaktionspartner

  1. Cardiomyocyte-specific overexpression of GTP cyclohydrolase I (mGCH) increases BH4 several-fold in the heart.

  2. gene expression analysis after iNOS (zeige NOS2 Antikörper) induction identified 78 genes that were altered between wild-type and Gch1(fl/fl (zeige FLT3LG Antikörper))Tie2cre macrophages

  3. Data indicate that global deficiency in GTP cyclohydrolase I (Gch1) is embryonically lethal between E11.5 and E13.5.

  4. There is a cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

  5. Inhibition of GCH1 prevented the Escherichia coli K1 induced expression of CD64 (zeige FCGR1A Antikörper) in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis.

  6. The GTPCH I/Tetreahydrobiopterin pathway is critical to preserve endothelial progenitor cells quantity, function, and regenerative capacity during wound healing in type 1 diabetic mice.

  7. maintenance of endothelial GTPCH I expression and the resulting improvement in BH4 biosynthesis ameliorate diabetic nephropathy

  8. The involvement of the GCH1 gene in pain models using the hyperphenylalaninemia 1 (hph-1 (zeige EGLN2 Antikörper)) mouse, is reported.

  9. GTPCH1 non-covalently interacts with polyubiquitin via an ubiquitin-binding domain.

  10. The data suggest that GCH1 inhibition reduces tumor growth by (i) direct killing of tumor cells, (ii) by inhibiting angiogenesis, and (iii) by enhancing the antitumoral immune response

GTP Cyclohydrolase 1 (GCH1) Antigen-Profil

Protein Überblick

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme.

Genbezeichner und Symbole assoziert mit GCH1

  • GTP cyclohydrolase 1 (GCH1) Antikörper
  • GTP cyclohydrolase 1 (Gch1) Antikörper
  • GTP cyclohydrolase 1 (gch1) Antikörper
  • GTP cyclohydrolase 1 (Weevi_1190) Antikörper
  • GTP cyclohydrolase 1 (Halhy_0838) Antikörper
  • GTP cyclohydrolase 1 (Sinme_1220) Antikörper
  • GTP cyclohydrolase 1 (Sphch_1077) Antikörper
  • GTP cyclohydrolase 1-like (LOC100136794) Antikörper
  • DYT5 Antikörper
  • DYT5a Antikörper
  • DYT14 Antikörper
  • Gch Antikörper
  • gch1a Antikörper
  • GTP-CH Antikörper
  • GTP-CH-1 Antikörper
  • GTPCH Antikörper
  • GTPCH1 Antikörper
  • HPABH4B Antikörper
  • MGC89622 Antikörper
  • wu:fc16b10 Antikörper
  • zgc:195269 Antikörper

Bezeichner auf Proteinebene für GCH1

GTP cyclohydrolase I , GTP-CH-I , dystonia 14 , guanosine 5'-triphosphate cyclohydrolase I , GTP cyclohydrolase 1 (dopa-responsive dystonia) , GTP cyclohydrolase 1 , GTP cyclohydrolase I (form A; N-terminus)

GENE ID SPEZIES
2643 Homo sapiens
609393 Canis lupus familiaris
286815 Bos taurus
695675 Macaca mulatta
743728 Pan troglodytes
396146 Gallus gallus
14528 Mus musculus
29244 Rattus norvegicus
448485 Xenopus (Silurana) tropicalis
10282422 Weeksella virosa DSM 16922
10584999 Haliscomenobacter hydrossis DSM 1100
10725797 Sinorhizobium meliloti AK83
10741394 Sphingobium chlorophenolicum L-1
100136794 Oncorhynchus mykiss
100192219 Danio rerio
100286831 Oryctolagus cuniculus
100303455 Ovis aries
100735198 Cavia porcellus
Ausgewählte Anbieter für anti-GTP Cyclohydrolase 1 (GCH1) Antikörper
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