GDNF Family Receptor alpha 2 Proteine (GFRA2)

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. Zusätzlich bieten wir Ihnen GFRA2 Antikörper (74) und GFRA2 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GFRA2 2675 O00451
Ratte GFRA2 GFRA2 25136  
GFRA2 14586  
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Showing 10 out of 17 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Human Cells Maus His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$272.80
Details
HEK-293 Cells Human His tag 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$615.00
Details
Human Cells Human His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$170.50
Details
Human Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$125.00
Details
HEK-293 Cells Human His tag Human GFR alpha-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. 200 μg Anmelden zum Anzeigen 2 bis 3 Tage
$308.00
Details
HEK-293 Cells Human Unkonjugiert Validation with Western Blot 10 μg Anmelden zum Anzeigen 12 bis 15 Tage
$345.35
Details
HEK-293 Human His tag   0.2 mg Anmelden zum Anzeigen 2 bis 3 Tage
$550.00
Details

GFRA2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , ,
, ,
Mouse (Murine) , ,
,

Weitere Proteine zu GDNF Family Receptor alpha 2 (GFRA2) Interaktionspartnern

Human GDNF Family Receptor alpha 2 (GFRA2) Interaktionspartner

  1. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET (zeige RET Proteine) tyrosine kinase (zeige TXK Proteine).

  2. High GFRalpha2 expression level leads to PTEN inactivation via Mir-17-5p up-regulation, promoting pancreatic tumor cell growth and chemoresistance.

  3. GFRA2 variants associated with diabetic neuropathic pain.

  4. The study shows co-localization of RET (zeige RET Proteine) with GFRA1 (zeige GFRA1 Proteine) and GFRA2 in myenteric ganglia of the adult human colon.

  5. Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms.

  6. GFRA2 genetic variants, and age, may play a role in susceptibility to tardive dyskinesia.

  7. This study found nominally-significant evidence for interactions between GFRA1 (zeige GFRA1 Proteine), 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia.

  8. Both GFR (zeige RAPGEF5 Proteine) alpha2a and GFR (zeige RAPGEF5 Proteine) alpha2c, but not GFR (zeige RAPGEF5 Proteine) alpha2b (zeige ADRA2B Proteine), promote neurite outgrowth in transfected Neuro2A cells.

Mouse (Murine) GDNF Family Receptor alpha 2 (GFRA2) Interaktionspartner

  1. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET (zeige RET Proteine) tyrosine kinase (zeige TYRO3 Proteine).

  2. Ret (zeige RET Proteine) and Gfra2 null mice display comparable early central projection deficits, but Gfra2 null rapidly adapting mechanoreceptors recover later.

  3. STAT3 (zeige STAT3 Proteine) phosphorylation by neurturin (zeige NRTN Proteine) was found to be mediated specifically by GFRalpha2c and RET9 (zeige RET Proteine) isoforms.

  4. Cholinergic innervation of gastric mucosa depends on neurturin (zeige NRTN Proteine)-GFRalpha2 signalling but is dispensable for gastrin (zeige GAST Proteine) secretion and for basal and maximal acid output

  5. our data demonstrate that RET (zeige RET Proteine)/GFRalpha signals are dispensable for thymic T cell development in vivo

  6. Transduction-function role for GFR (zeige RAPGEF5 Proteine) alpha2/neurturin (zeige NRTN Proteine) signalling in a specific class of sensory neurons.

  7. The cholinergic subpopulation of sympathetic neurons requires GFR alpha 2 signaling for soma size and for growth or maintenance of target innervation.

  8. Demonstrate a role for GFRalpha2-expressing enteric neurons in the downstream signaling of the glucagon (zeige GCG Proteine)-like peptides to inhibit GI motility, but not in intestinal growth.

GFRA2 Protein Überblick

Protein Überblick

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit GFRA2

  • DKFZP459C0228 protein (DKFZP459C0228)
  • GDNF family receptor alpha 2 (gfra2)
  • GDNF family receptor alpha 2a (gfra2a)
  • GDNF family receptor alpha 2 (GFRA2)
  • GDNF family receptor alpha 2 (Gfra2)
  • glial cell line derived neurotrophic factor family receptor alpha 2 (Gfra2)
  • DKFZP459C0228 Protein
  • GDNFRB Protein
  • gfra2 Protein
  • NRTNR-ALPHA Protein
  • NTNRA Protein
  • NTNRALPHA Protein
  • Retl2 Protein
  • TRNR2 Protein

Bezeichner auf Proteinebene für GFRA2

DKFZP459C0228 protein , GFR-alpha-2 , GDNF family receptor alpha-2 , GDNF family receptor alpha 2 , glial cell line derived neurotrophic factor family receptor alpha 2 , GFR alpha 2 , GDNF family receptor alpha-2-like , GDNF receptor beta , GDNFR-alpha-2 , GDNFR-beta , GFR-alpha 2 , NTNR-alpha , PI-linked cell-surface accessory protein , RET ligand 2 , TGF-beta-related neurotrophic factor receptor 2 , TRN receptor, GPI-anchored , glial cell line derived neurotrophic factor receptor, beta , neurturin receptor alpha , GDNF receptor alpha-2 , tyrosine kinase receptor ligand 2 , NRTNR-alpha , GFR alpha-2

GENE ID SPEZIES
100189713 Pongo abelii
100127717 Xenopus (Silurana) tropicalis
405794 Danio rerio
100475044 Ailuropoda melanoleuca
2675 Homo sapiens
609172 Canis lupus familiaris
514036 Bos taurus
25136 Rattus norvegicus
395993 Gallus gallus
100171804 Pongo abelii
14586 Mus musculus
Ausgewählte Anbieter für GFRA2 Proteine (GFRA2)
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