anti-G Protein-Coupled Receptor 143 (GPR143) Antikörper

GPR143 encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. Zusätzlich bieten wir Ihnen G Protein-Coupled Receptor 143 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GPR143 4935 P51810
GPR143 18241 P70259
GPR143 302619  
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Showing 10 out of 49 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IF, ELISA Immunofluorescence analysis of LOVO cells, using GPR143 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of GPR143 expression in A549 (A), NS-1 (B), PC12 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 11 bis 13 Tage
464,29 €
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Human Kaninchen Unkonjugiert IHC (p) Anti-GPR143 antibody  ABIN1048724 IHC staining of human eye, retina. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
501,70 €
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Human Kaninchen Unkonjugiert IF, ELISA 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
565,71 €
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Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cells, using GPR143 antibody. 100 μL Anmelden zum Anzeigen 12 Days
261,90 €
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Human Kaninchen Unkonjugiert ELISA, WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
460,95 €
Details
Human Kaninchen Unkonjugiert ELISA, IF   100 μL Anmelden zum Anzeigen 13 Days
154,33 €
Details
Human Kaninchen Unkonjugiert IHC (p), IHC Immunohistochemistry-Paraffin: OA1 Antibody [NLS2123] - Ocular Albinism 1 (Nettleship Falls; OA1) detection using this antibody at 16 ug/ml on human eye (retina). 0.05 mL Anmelden zum Anzeigen 2 bis 4 Tage
341,00 €
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Human Kaninchen Unkonjugiert ELISA, WB TheGPR143 Antibody is used in Western blot to detect GPR142 in HeLa cells lysates. 0.1 mg Anmelden zum Anzeigen 6 bis 11 Tage
410,67 €
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Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 11 bis 14 Tage
443,50 €
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GPR143 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen G Protein-Coupled Receptor 143 Interaktionspartner

Human G Protein-Coupled Receptor 143 (GPR143) Interaktionspartner

  1. c.758T>A mutation in exon 6 of the GPR143 gene is associated with X-linked ocular albinism.

  2. Our results expand the spectrum of GPR143 mutations causing CN and further confirm the role of GPR143 in the pathogenesis of CN.

  3. tyrosinase (zeige TYR Antikörper) as a potential GPR143 binding protein opens new avenues for investigating the mechanisms that regulate pigmentation and neurogenesis.

  4. X-linked ocular albinism type I, characterized by developmental eye defects, results from GPR143 mutations

  5. This family was found to harbor a novel, likely pathogenic mutation in GPR143 resulting in a combined Stargart disease and heterozygous carrier phenotype in the affected sisters .

  6. Here, we report a Chinese trio (zeige TRIO Antikörper)-family with the son who was affected by the X-linked ocular albinism in which a novel missense mutation in the GPR143 was observed.

  7. Twenty Chinese patients, including 15 sporadic IN cases and 5 from X-linked IN families, were recruited and underwent molecular genetic analysis. We first performed PCR-based DNA sequencing of the entire coding region and the splice junctions of the FRMD7 (zeige FRMD7 Antikörper) and GPR143 genes in participants.

  8. Downstream signaling from GPR143 controls RPE (zeige RPE Antikörper) secretion of pigment epithelium-derived factor (PEDF (zeige SERPINF1 Antikörper)), a potent neurotrophic and antiangiogenic factor.

  9. Five mutations in GPR143 gene were detected in each of the five families, including a novel nonsense mutation of c.333G>A,two novel splicing mutations of c.360+1G>C and c.659-1G>A, a novel small deletion mutation of c.43_50dupGACGCAGC.

  10. intronic mutation that creates a cryptic splice-donor site in GPR143 of patients with ocular albinism

Mouse (Murine) G Protein-Coupled Receptor 143 (GPR143) Interaktionspartner

  1. OA1 expression in both neuronal and non-neuronal tissues was examined by immunohistochemical analyses, results suggested that OA1 may modulate the monoaminergic functions in both peripheral and central nervous systems

  2. Melanosome-autonomous regulation of size and number: the OA1 receptor sustains PMEL (zeige PMEL Antikörper) expression.

  3. These results identify the Oa1 transducer Galphai3 (zeige GNAI3 Antikörper) as the first downstream component in the Oa1 signaling pathway.

  4. OA1 interacts with MART-1 (zeige RTL1 Antikörper) at early stages of melanogenesis to control melanosome identity and composition.

  5. Asparagine at amino acid 106 is essential for N-glycosylation of the Oa1 protein. Mutation at amino acid 106 that eliminated glycosylation did not affect the endo/lysosomal distribution of Oa1 protein in cells.

  6. the ocular albinism type 1 gene expression is controlled by microphthalmia transcription factor (Mitf (zeige MITF Antikörper))

  7. The findings indicate that Oa1 is involved in the regulation of melanosome maturation at two steps, Oa1 controls the abundance of melanosomes in RPE (zeige RPE Antikörper) cells and has a function in the maintenance of a correct melanosomal size.

  8. G alpha i3, like Oa1, plays important role in melanosome biogenesis. Common Oa1-G alpha i3 signaling pathway may ultimately affect axonal growth through optic chiasm.

  9. data point to defective regulation of organelle transport in pigment cells in absence of OA1; results enlighten novel function for OA1 in pigment cells & suggest ocular albinism type 1 may result from a different mechanism than previously thought

G Protein-Coupled Receptor 143 (GPR143) Antigen-Profil

Protein Überblick

This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y.

Genbezeichner und Symbole assoziert mit GPR143

  • G protein-coupled receptor 143 (GPR143) Antikörper
  • G protein-coupled receptor 143 (Gpr143) Antikörper
  • NYS6 Antikörper
  • Oa1 Antikörper
  • RGD1565799 Antikörper

Bezeichner auf Proteinebene für GPR143

G-protein coupled receptor 143 , ocular albinism type 1 protein , MOA1 , homolog of human ocular albinism 1 (Nettleship-Falls) , ocular albinism type 1 protein homolog

GENE ID SPEZIES
4935 Homo sapiens
18241 Mus musculus
302619 Rattus norvegicus
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