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Receptor for an unknown ligand. Zusätzlich bieten wir Ihnen G Protein-Coupled Receptor 132 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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coexpression of OGR1- and G2A-enhanced proton sensitivity and proton-induced calcium signals. This alteration is attributed to oligomerization of OGR1 and G2A. The oligomeric potential locates receptors at a specific site, which leads to enhanced
we found an additional novel G2A variant (G2A-b) that is the major transcript with functional response to ligand stimulation as well as G2A-a, and succeeded in discriminating proton-sensing and oxidized fatty acid-sensing activities of G2A.
G2A is a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene
In atherosclerotic plaques of human coronary arterial specimens, G2A is expressed by macrophages within the lipid-r (zeige APOE Antikörper)ich plaques, whereas no immunoreactivity of G2A is observed in fibrous plaques where macrophages do not exist.
G2A can activate a specific combination of G proteins, and G2A/LPC (zeige PCSK7 Antikörper)-induced apoptosis involves both G alpha(13 (zeige GNA13 Antikörper))- and G alpha(s (zeige GNAS Antikörper))-mediated pathways
G2A was not detected in either brain or skin vascular endothelial cell type.
G2A is a proton-sensing G-protein-coupled receptor (zeige ADRA1A Antikörper) antagonized by lysophosphatidylcholine
Activity of the human G2A receptor is less sensitive to pH fluctuations as measured by inositol phosphate and cAMP accumulation.
results indicate that G protein-coupled receptor G2A is a receptor for 9-hydroxyoctadecadienoic acid (9-HODE) and other oxidized free fatty acids and is activated by oxidized free fatty acids
G2A latent within neutrophil secretory vesicles may facilitate signaling through lysophospholipids for neutrophil activation and calcium flux.
The authors report that macrophage PPARgamma (zeige PPARG Antikörper) deletion in mice not only exacerbates mammary tumor development but also impairs the anti-tumor effects of rosiglitazone. Mechanistically, the authors identify Gpr132 as a novel direct PPARgamma (zeige PPARG Antikörper) target in macrophage whose expression is enhanced by PPARgamma (zeige PPARG Antikörper) loss but repressed by PPARgamma (zeige PPARG Antikörper) activation.
the data suggest that G2A signaling serves to dampen intestinal inflammation via the production of IFN-gamma (zeige IFNG Antikörper), which, in turn, enhances monocyte maturation to a less inflammatory program and ultimately reduces eosinophil-induced injury of colonic tissues
Lyso-PS signaled to macrophages in a G2A-dependent manner for their enhanced production of prostaglandin E2 (PGE2) via a calcium-dependent cytosolic phospholipase A2 (zeige PLA2G4A Antikörper)/cyclooxygenase-mediated mechanism.
G2A is expressed predominantly by macrophages within atherosclerotic lesions at the aortic root of apolipoprotein E (zeige APOE Antikörper)-deficient mice.
role of G2A in lysophosphatidylcholine-mediated T-cell migration
G2A signaling regulates macrophage chemotaxis to lysophosp[hatidylcholine.
data indicate the ability of lysophosphatidylcholine to stimulate macrophage & T-cell chemotaxis via G2A is not manifested in vivo & G2A-mediated proapoptotic rather than chemotactic action is most penetrant during atherogenesis
the neuritogenic effect of sPLA2 is mediated by generation of LPC and subsequent activation of G2A
Examination of lipoprotein profiles revealed elevated levels of circulating high-density lipoprotein (HDL (zeige HSD11B1 Antikörper)) cholesterol in G2A-/- LDLR (zeige LDLR Antikörper)-/- mice compared with their G2A+/+ LDLR (zeige LDLR Antikörper)-/- counterparts after extended periods of diet intervention.
Endothelial G2A expression may aid in prevention of vascular inflammation and atherosclerosis.
Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication.
G protein-coupled receptor 132
, probable G-protein coupled receptor 132-like
, G2 accumulation protein
, probable G-protein coupled receptor 132
, G protein-coupled receptor G2A
, G protein-coupled receptor G2a