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FLI1 encodes a transcription factor containing an ETS DNA-binding domain. Zusätzlich bieten wir Ihnen Friend Leukemia Virus Integration 1 Antikörper (158) und Friend Leukemia Virus Integration 1 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.
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Study found consistent DNA hypomethylation at enhancers regulated by the disease-defining EWS (zeige EWSR1 Proteine)-FLI1 fusion protein, thus establishing epigenomic enhancer reprogramming as a ubiquitous and characteristic feature of Ewing sarcoma.
loss of ERG (zeige ERG Proteine) and FLI1 might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.
study shows that FLI-1 is expressed variably in different subtypes of NSCLC, and its expression is related to clinicopathologic parameters and poorer prognosis
ERG (zeige ERG Proteine) (or FLI1 if available) is useful marker for the diagnosis of Phosphaturic mesenchymal tumors.
FLI1 and MMP9 (zeige MMP9 Proteine) position differently in prostate cancer than in normal tissue and prostate hyperplasia, whereas MMP2 (zeige MMP2 Proteine) is repositioned in both prostate cancer and hyperplasia.
FLI1 promoter hypermethylation is associated with Colorectal Cancer.
Concurrent exogenous expression of three transcription factors, GATA1 (zeige GATA1 Proteine), FLI1 and TAL1 (zeige TAL1 Proteine), enables large-scale production of megakaryocytes from human pluripotent stem cells.
Identify SP1 (zeige PSG1 Proteine) and PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling as modulators of EWS (zeige EWSR1 Proteine)/FLI1 gene expression in tumor cell lines.
This study for the first time identifies FLI1 as a clinically and functionally important target gene of metastasis, providing a rationale for developing FLI1 inhibitors in the treatment of breast cancer.
SLFN11 has a role as a transcriptional target of EWS (zeige EWSR1 Proteine)-FLI1 and is a determinant of drug response in Ewing sarcoma
These results provide the first evidences that Fli-1 positively regulates LPS (zeige TLR4 Proteine)-induced IL-27 (zeige IL27 Proteine) production in macrophages
protective against nephritis MRL/lpr (zeige FAS Proteine) mice
Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review)
The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 (zeige ETS1 Proteine) and FLI1.
Simultaneous downregulation of KLF5 (zeige KLF5 Proteine) and Fli1 is a key feature underlying systemic sclerosis.
bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts
FLI1 and GATA2 (zeige GATA2 Proteine) are upstream regulators of SMAD1 (zeige SMAD1 Proteine) and SMAD5 (zeige SMAD5 Proteine) expression in endothelial cells.
These results demonstrate that Fli-1 is a novel regulator of the proinflammatory chemokine (zeige CCL1 Proteine) MCP-1 (zeige CPT1B Proteine).
Fli-1 directly increases the expression of IL-6 (zeige IL6 Proteine) via promoter region binding. This represents one possible mechanism for the protective effect of decreased Fli-1 expression in lupus.
Fli+ etsrp (zeige ETV2 Proteine)+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
These results showed that young thrombocytes have higher GATA1 (zeige GATA1 Proteine) promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
fli1, and etsrp (zeige ETV2 Proteine), demonstrated that erg (zeige KCNH2 Proteine) and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (zeige CDH5 Proteine)
Interaction between EWSR1 (zeige EWSR1 Proteine)/FLI1 and EWSR1 (zeige EWSR1 Proteine) in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11\;22)(q24\;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4\;11)(q21\;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Friend leukemia virus integration 1
, friend leukemia integration 1 transcription factor-like
, Friend leukemia integration 1 transcription factor-like
, Ewing sarcoma breakpoint region 2
, Friend leukemia integration 1 transcription factor
, proto-oncogene Fli-1
, transcription factor ERGB
, retroviral integration site protein Fli-1 homolog
, retroviral integration site protein Fli-1
, fli-1 proto-oncogene