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The protein encoded by FOXN1 is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. Zusätzlich bieten wir Ihnen FOXN1 Antikörper (82) und FOXN1 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
the foxn1-mcm2 (zeige MCM2 ELISA Kits) axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish
zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment
an evolutionarily conserved role of BMP signaling in the maintenance of Foxn1 expression.
FOXN1 founder Italian mutation identified in an indian newborn with severe combined immunodeficiency (zeige PRKDC ELISA Kits).
Whole-exome sequencing in a South American coh (zeige RARB ELISA Kits)ort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism s (zeige ALDH1A3 ELISA Kits)pectrum disorders.
Identification of a unique mutation in FOXN1 that led to severe combined immunodeficiency (zeige PRKDC ELISA Kits) in a female infant is reported.
These results show that miR (zeige MLXIP ELISA Kits)-18b and miR (zeige MLXIP ELISA Kits)-518b are upstream controllers of FOXN1-directed epithelial lineage development.
The retinoid-related orphan receptor (zeige NR1D2 ELISA Kits) RORalpha promotes keratinocyte differentiation via FOXN1.
This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation.
results show that FOXN1 is crucial for in utero T cell development, but not for B and NK cell differentiation
role of FOXN1 in immunological disorders characterized by abnormal T-cell development or abnormal T-cell regulatory homeostasis [Review]
study uncovered a positive regulatory loop between FGFR3 (zeige FGFR3 ELISA Kits) and FOXN1 that underlies a benign versus malignant skin tumor phenotype
Mutation of the FOXN1 gene is associated with congenital severe combined immunodeficiency (zeige PRKDC ELISA Kits) associated with alopecia
MicroRNA-205 maintains T cell development following stress by regulating Foxn1 (zeige FOXN2 ELISA Kits) and its two regulated targets, stem cell factor (zeige KITLG ELISA Kits) and ccl25 (zeige CCL25 ELISA Kits), following stress.
this study identified Bmp4 (zeige BMP4 ELISA Kits) as a significant factor for improved maintenance of Foxn1 (zeige FOXN2 ELISA Kits) expression, promotion of thymic epithelial progenitor populations self-renewal and immature epithelial cell differentiation and survival
results show that Foxn1 (zeige FOXN2 ELISA Kits), and alleles under its control, are expressed in the pre-meiotic male germline, revealing a new tool for germline targeting of genes, and raising important concerns for gender selection when using Foxn1 (zeige FOXN2 ELISA Kits) regulatory elements.
this study shows that critical events in thymic lympho-stromal cross-talk and T cell selection are regulated by Foxn1 (zeige FOXN2 ELISA Kits)
sphingolipids and fatty acids associated with a decrease in glycerolipids suggest that the lipidome in mice skin is regulated by the Foxn1 (zeige FOXN2 ELISA Kits) gene
Foxn1 (zeige FOXN2 ELISA Kits) transcription factor regulates wound healing of skin through promoting epithelial-mesenchymal transition.
early differentiation and maturation of cortical and medullary thymic epithelial cells coincides with precise sub-lineage-specific regulation of Foxn1 (zeige FOXN2 ELISA Kits) expression levels.
Chromatin immunoprecipitation assay using RarB (zeige RARB ELISA Kits) as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 (zeige ALDH1A3 ELISA Kits) and Foxn1 (zeige FOXN2 ELISA Kits) in mice.
The maturation and distribution of thymic epithelial cells in the Foxn1 (zeige FOXN2 ELISA Kits)(-/-) thymic rudiment and the thymopoiesis of this newly developed rudiment, were examined.
Expression of FoxN1 (zeige FOXN2 ELISA Kits) in early life adversely influence immature epithelial cells T and B cell, and skin epithelial development.
The protein encoded by this gene is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. This gene family has over 100 members, subdivided into classes (A-Q) based on phylogeny. The encoded protein is proposed to regulate development of the thymus and differentiation of keratinocytes. Mutations in this gene cause severe primary T-cell immunodeficiency and congenital alopecia. In mouse mutations of this gene underlie the phenotype of the nude mouse, which has been widely used as a model system in oncology, immunology, dermatology, and transplantation studies. In humans mutations in this gene have been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
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