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FABP5 encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Zusätzlich bieten wir Ihnen FABP5 Antikörper (51) und FABP5 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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Using a yeast two-hybrid screen, immunoprecipitation, microscale thermophoresis analysis and cellular fractionation, we discovered that Fabp5 interacts with the calnexin (zeige CANX ELISA Kits) cytoplasmic C-tail domain at the endoplasmic reticulum. These observations identify Fabp5 as a previously unrecognized calnexin (zeige CANX ELISA Kits) binding partner.
Following infection with Listeria monocytogenes, we observed similar clonal expansion, contraction and formation of memory CD8 (zeige CD8A PLURAL_@16727@) T cells in WT and E-FABP (zeige FABP5L1 PLURAL_@16727@)-/- mice. Analysis of Listeria-specific CD4 (zeige CD4 PLURAL_@16727@) T cells revealed no defect in the expansion, contraction, and formation of memory CD4 (zeige CD4 PLURAL_@16727@) T cells in E-FABP (zeige FABP5L1 PLURAL_@16727@)-/- mice. Our data demonstrate that E-FABP (zeige FABP5L1 PLURAL_@16727@) is dispensable for antigen-specific T cell response following bacterial infection.
Genetic deletion of fatty acid-binding protein 5 (FABP5) in mice reduces uptake of exogenous docosahexaenoic acid (DHA) into brain endothelial cells and brain capillaries and reduces brain parenchymal levels of endogenous DHA. Therefore, FABP5 in the brain endothelial cell is a crucial contributor to the brain levels of DHA. Critically, lowered brain DHA levels in FABP5(-/-) mice occurred in tandem with cognitive deficits
the balance between FABP4 (zeige FABP4 PLURAL_@16727@) and FABP5 in endothelial cells may be important in regulation of angiogenic versus quiescent phenotypes in blood vessels.
Mice lacking FABP5 and FABP7 (zeige FABP7 ELISA Kits), which exhibit highest affinities for endocannabinoids, possessed elevated levels of the endocannabinoid anandamide and the related N-acylethanolamines palmitoylethanolamide and oleoylethanolamide.
These studies show, for the first time, a correlation between FABP5 and EGFR (zeige EGFR ELISA Kits) in enhancing TNBC metastasis through a novel mechanism
loss of FABP5 promotes a more anti-inflammatory response.
Circulating levels of GIP (zeige GIP PLURAL_@16727@) were significantly decreased in FABP5-deficient mice.
The frameshift and missense mutations in FABP3 (zeige FABP3 ELISA Kits), FABP5, and FABP7 (zeige FABP7 ELISA Kits) genes have been identified in schizophrenia and autism spectrum disorder in humans and in mouse behavioral studies.
FABP5 contributes to the development of Diet-induced obesity in a gastric inhibitory polypeptide (zeige GIP ELISA Kits)-dependent manner.
A high expression ratio between FABP5 and CRABPII (zeige CRABP2 ELISA Kits) may be related to CP tumor recurrence and ATRA could be a potential therapeutic agent for CP chemotherapy.
Data suggest that antinociceptive agent SBFI-26 binds at a portal site as well as at the canonical site in the substrate pocket of FABP5 and FABP7 (zeige FABP7 ELISA Kits); only the S form of SBFI-26 binds to both FABP5 and FABP7 (zeige FABP7 ELISA Kits) in their co-crystal structures; SBFI-26 induces conformational changes in FABP5 and FABP7 (zeige FABP7 ELISA Kits).
secreted FABP4 (zeige FABP4 PLURAL_@16727@) and FABP5 from adipocytes as adipokines differentially affect transcriptional and metabolic regulation in ADSC near adipocytes
FABP5 plays an important role in the carcinogenesis and metastasis of cervical cancer, and FABP5 may be a novel predictor for prognostic assessment of cervical cancer patients.
FABP5 promoted VEGF (zeige VEGFA PLURAL_@16727@) expression and angiogenesis through PPARgamma (zeige PPARG PLURAL_@16727@) which was activated by fatty acids transported by FABP5.
FABP5 is associated with increased subclinical atherosclerosis
Long chain fatty acids suppress the oncogenic properties of FABP5-expressing carcinoma cells in cultured cells.
silencing of Sp1 (zeige PSG1 ELISA Kits), c-Myc (zeige MYC ELISA Kits) or FABP5 expression led to a significant decrease in cell proliferation, indicating that up-regulation of FABP5 expression by Sp1 (zeige PSG1 ELISA Kits) and c-Myc (zeige MYC ELISA Kits) is critical for the proliferation of prostate cancer cells
FABP5 may contribute to the airway remodeling and inflammation in asthma by fine-tuning the levels of CysLTs, which induce VEGF production.
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.
epidermal-type fatty acid-binding protein
, epithelial fatty acid-binding protein
, fatty acid-binding protein, epidermal
, keratinocyte lipid-binding protein
, psoriasis-associated fatty acid-binding protein homolog
, fatty acid binding protein 5
, differentiation-associated lipid-binding protein LP2
, epidermal fatty acid-binding protein
, fatty acid-binding protein 5
, cutaneous fatty acid-binding protein