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The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Zusätzlich bieten wir Ihnen FANCI Proteine (3) und FANCI Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal FANCI Primary Antibody für WB - ABIN152583
Yuan, El Hokayem, Zhou, Zhang: FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures. in The Journal of biological chemistry 2009
Show all 2 Pubmed References
Human Polyclonal FANCI Primary Antibody für IP, WB - ABIN253065
Colnaghi, Jones, Cotto-Rios, Schindler, Hanenberg, Huang: Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair. in Blood 2011
FANCB (zeige BRCA2 Antikörper) dimer coordinates FANCD2 (zeige FANCD2 Antikörper):FANCI monoubiquitination by two FANCL (zeige FANCL Antikörper) RING-ligases. Deubiquitination of FANCD2 (zeige FANCD2 Antikörper):FANCI by USP1 (zeige USP1 Antikörper):UAF1 (zeige WDR48 Antikörper) occurs only when DNA is removed.
depletion of FANCI, but not FANCD2 (zeige FANCD2 Antikörper) or USP1 (zeige USP1 Antikörper), results in increased phosphorylation and activation of Akt (zeige AKT1 Antikörper).
FANCI mutations are associated with Fanconi anemia (zeige PALB2 Antikörper) in VACTERL association.
FANCJ (zeige BRIP1 Antikörper) protein is important for the stability of FANCD2 (zeige FANCD2 Antikörper)/FANCI proteins and protects them from proteasome and caspase-3 (zeige CASP3 Antikörper) dependent degradation.
These findings indicate that FANCI functions upstream of FA core complex recruitment independently of FANCD2 (zeige FANCD2 Antikörper), and alter the current view of the FA-BRCA pathway.
these purification methods for human FANCI and FANCD2 (zeige FANCD2 Antikörper) provide novel procedures to facilitate structural and biochemical studies of human FANCI and FANCD2 (zeige FANCD2 Antikörper).
Results show that ATR (zeige ANTXR1 Antikörper)-mediated phosphorylation of FANCI, controls dormant origin firing in response to DNA replication stress.
Our studies reveal a previously unknown mechanism for the coordinate nuclear import of a subset of FANCD2 and FANCI, a key early step in the cellular ICL response.
Mutations in FANCI that impair its DNA binding activity compromise DNA-stimulated FANCD2 (zeige FANCD2 Antikörper) monoubiquitination.
A CUE ubiquitin-binding domain in the FANCD2 (zeige FANCD2 Antikörper) protein is required for interaction with FANCI, retention of monoubiquitinated FANCD2 (zeige FANCD2 Antikörper), and FANCI in chromatin, and for efficient DNA interstrand crosslinks repair.
crystal structure of FANCI-FANCD2 (zeige FANCD2 Antikörper)(ID) complex; crystallographic electron-density map of FANCI protein bound to splayed Y DNA; data suggest ID complex recognizes DNA structures resulting from encounter of replication forks with an interstrand cross-link
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms.
Fanconi anemia group I protein
, Fanconi anemia group I protein homolog