anti-Fanconi Anemia Complementation Group I (FANCI) Antikörper

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Zusätzlich bieten wir Ihnen FANCI Proteine (3) und FANCI Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
FANCI 55215 Q9NVI1
Anti-Maus FANCI FANCI 208836 Q8K368
FANCI    
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Top anti-FANCI Antikörper auf antikoerper-online.de

Showing 10 out of 28 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IP, WB Western Blot and Immunoprecipitation: FANCI Antibody [ABIN253065] - Detection of Human FANCI by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) and 293T (T, 50 mcg) cells. Antibodies: Affinity purified rabbit anti- FANCI antibody ABIN253065 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. FANCI was also immunoprecipitated, albeit less efficiently, by another rabbit anti-FANCI antibody, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B). Western Blot: FANCI Antibody  - Detection of Human FANCI by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa and 293T cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-FANCI antibody  used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
Details
Human Kaninchen Unkonjugiert WB Western Blot: FANCI Antibody  - Detection of Human FANCI by Western Blot. Samples : Nuclear extract (5 and 20 ug) from HeLa cells. Antibody : Affinity purified rabbit anti-FANCI antibody used at 0.2 ug/ml. Detection : Chemiluminescence with an exposure time of 15 minutes. 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cells, using FANCI antibody. 100 μL Anmelden zum Anzeigen 12 Days
392,86 €
Details
Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: FANCI Antibody [NBP1-84608] - Staining of human testis shows strong nuclear positivity in cells in seminiferus ducts. Immunocytochemistry/Immunofluorescence: FANCI Antibody [NBP1-84608] - Staining of human cell line A-431 shows positivity in nucleus & plasma membrane. 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details
Human Kaninchen Unkonjugiert ICC, IF Immunocytochemistry/Immunofluorescence: FANCI Antibody  - Staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol. 100 μL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 2 bis 4 Tage
291,00 €
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Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 2 bis 4 Tage
291,00 €
Details
Human Kaninchen Unkonjugiert IP, WB   100 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.019,69 €
Details
Human Kaninchen Unkonjugiert IF, ELISA, WB   50 μL Anmelden zum Anzeigen 11 bis 15 Tage
298,57 €
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FANCI Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Human , ,
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Am meisten referenzierte anti-FANCI Antikörper

  1. Human Polyclonal FANCI Primary Antibody für WB - ABIN152583 : Yuan, El Hokayem, Zhou, Zhang: FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal FANCI Primary Antibody für IP, WB - ABIN253065 : Colnaghi, Jones, Cotto-Rios, Schindler, Hanenberg, Huang: Patient-derived C-terminal mutation of FANCI causes protein mislocalization and reveals putative EDGE motif function in DNA repair. in Blood 2011 (PubMed)

Weitere Antikörper gegen FANCI Interaktionspartner

Human Fanconi Anemia Complementation Group I (FANCI) Interaktionspartner

  1. FANCB (zeige BRCA2 Antikörper) dimer coordinates FANCD2 (zeige FANCD2 Antikörper):FANCI monoubiquitination by two FANCL (zeige FANCL Antikörper) RING-ligases. Deubiquitination of FANCD2 (zeige FANCD2 Antikörper):FANCI by USP1 (zeige USP1 Antikörper):UAF1 (zeige WDR48 Antikörper) occurs only when DNA is removed.

  2. depletion of FANCI, but not FANCD2 (zeige FANCD2 Antikörper) or USP1 (zeige USP1 Antikörper), results in increased phosphorylation and activation of Akt (zeige AKT1 Antikörper).

  3. FANCI mutations are associated with Fanconi anemia (zeige PALB2 Antikörper) in VACTERL association.

  4. FANCJ (zeige BRIP1 Antikörper) protein is important for the stability of FANCD2 (zeige FANCD2 Antikörper)/FANCI proteins and protects them from proteasome and caspase-3 (zeige CASP3 Antikörper) dependent degradation.

  5. These findings indicate that FANCI functions upstream of FA core complex recruitment independently of FANCD2 (zeige FANCD2 Antikörper), and alter the current view of the FA-BRCA pathway.

  6. these purification methods for human FANCI and FANCD2 (zeige FANCD2 Antikörper) provide novel procedures to facilitate structural and biochemical studies of human FANCI and FANCD2 (zeige FANCD2 Antikörper).

  7. Results show that ATR (zeige ANTXR1 Antikörper)-mediated phosphorylation of FANCI, controls dormant origin firing in response to DNA replication stress.

  8. Our studies reveal a previously unknown mechanism for the coordinate nuclear import of a subset of FANCD2 and FANCI, a key early step in the cellular ICL response.

  9. Mutations in FANCI that impair its DNA binding activity compromise DNA-stimulated FANCD2 (zeige FANCD2 Antikörper) monoubiquitination.

  10. A CUE ubiquitin-binding domain in the FANCD2 (zeige FANCD2 Antikörper) protein is required for interaction with FANCI, retention of monoubiquitinated FANCD2 (zeige FANCD2 Antikörper), and FANCI in chromatin, and for efficient DNA interstrand crosslinks repair.

Mouse (Murine) Fanconi Anemia Complementation Group I (FANCI) Interaktionspartner

  1. crystal structure of FANCI-FANCD2 (zeige FANCD2 Antikörper)(ID) complex; crystallographic electron-density map of FANCI protein bound to splayed Y DNA; data suggest ID complex recognizes DNA structures resulting from encounter of replication forks with an interstrand cross-link

FANCI Antigen-Profil

Protein Überblick

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group I. Alternative splicing results in two transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit FANCI

  • Fanconi anemia, complementation group I (FANCI) Antikörper
  • Fanconi anemia, complementation group I (Fanci) Antikörper
  • KIAA1794 Antikörper

Bezeichner auf Proteinebene für FANCI

Fanconi anemia group I protein , Fanconi anemia group I protein homolog

GENE ID SPEZIES
55215 Homo sapiens
208836 Mus musculus
Ausgewählte Anbieter für anti-FANCI (FANCI) Antikörper
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