anti-FRAS1 Related Extracellular Matrix 1 (FREM1) Antikörper

FREM1 encodes a basement membrane protein that may play a role in craniofacial and renal development. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
FREM1 158326 Q5H8C1
FREM1 298185  
FREM1 329872 Q684R7
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Top anti-FRAS1 Related Extracellular Matrix 1 Antikörper auf antikoerper-online.de

Showing 10 out of 29 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ICC, IHC (p), ELISA, WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details
Human Kaninchen Unkonjugiert EIA, IF, WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$375.38
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, WB Immunocytochemistry/Immunofluorescence: QBRICK/FREM1 Antibody [NBP1-77180] - K562 cells with FREM1 antibody at 20 ug/mL. Western Blot: QBRICK/FREM1 Antibody [NBP1-77180] - K562 cell lysate with FREM1 antibody at (A) 0.5 and (B) 1ug/mL. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Human Kaninchen Unkonjugiert EIA, IF, IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$500.50
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p) Paraformaldehyde-fixed, paraffin embedded rat liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with FREM1 Polyclonal Antibody, Unconjugated (bs-13213R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody for 20 minutes and DAB staining. 100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$295.90
Details
Human Kaninchen Alexa Fluor 350 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen Alexa Fluor 488 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen Alexa Fluor 555 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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Human Kaninchen Alexa Fluor 647 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen HRP IHC (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details

FREM1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen FRAS1 Related Extracellular Matrix 1 Interaktionspartner

Human FRAS1 Related Extracellular Matrix 1 (FREM1) Interaktionspartner

  1. we identified genome-wide significant association involving measures of central upper lip height at 9p22 within FREM1

  2. FREM1 expression is significantly downregulated in human masticatory mucosa during wound healing

  3. this report describes a patient with a phenotype compatible with Manitoba-oculo-tricho-anal syndrome in whom two novel FREM1 mutations were identified in the compound heterozygous state thus broadening the mutational spectrum of the disease.

  4. In 15 of 590 families, we identified recessive mutations in the genes FRAS1 (zeige FRAS1 Antikörper), FREM2 (zeige FREM2 Antikörper), GRIP1 (zeige NCOA2 Antikörper), FREM1, ITGA8, and GREM1 (zeige GREM1 Antikörper), all of which function in the interaction of the ureteric bud and the metanephric mesenchyme.

  5. Disruption of the FREM1 gene can produce a spectrum of clinical manifestations encompassing the previously described MOTA and BNAR syndromes.

  6. We conclude that FREM1 plays a critical role in the development of the diaphragm and that FREM1 deficiency can cause CDH (zeige CHDH Antikörper) in both humans and mice.

  7. The significant association of rs1552896 with an HIV-resistant phenotype, together with the expression profile of FREM1 in tissues relevant to HIV infection, suggests that FREM1 is a potentially novel candidate gene for resistance to HIV infection.

  8. The location of the IBD region 16 kb from FREM1 suggests the phenotype in Manitoba oculotrichoanal syndrome patients is attributable to a variant outside of FREM1, potentially in a regulatory element.

  9. FREM1 encodes a basement membrane protein of FRAS1-related extracellular matrix protein 1 which is required for epidermal adhesion during embryonic development

  10. a role for TILRR in selective amplification of NF-kappaB (zeige NFKB1 Antikörper) responses through IL-1RI and suggest that the specificity is determined by changes in receptor conformation and adapter protein (zeige TOLLIP Antikörper) recruitment.

Mouse (Murine) FRAS1 Related Extracellular Matrix 1 (FREM1) Interaktionspartner

  1. loss of FREM1 function promotes epidermal blistering in Fraser syndrome as a consequence of reduced PDGFC (zeige PDGFC Antikörper) activity, in addition to its stabilising role in the basement membrane

  2. FREM1-deficient mice faithfully recapitulate many of the phenotypes seen in individuals with FREM1 deficiency and that variations in GATA4 (zeige GATA4 Antikörper) and SLIT3 (zeige SLIT3 Antikörper) expression modulate some FREM1-related phenotypes in mice.

  3. We conclude that FREM1 plays a critical role in the development of the diaphragm and that FREM1 deficiency can cause CDH (zeige CHDH Antikörper) in both humans and mice.

  4. the loss of QBRICK significantly diminished The expression of nephronectin (zeige NPNT Antikörper), an integrin alpha8beta1 ligand necessary for renal development.

  5. Frem1 mutant mice is the first bona fide mouse model of human metopic craniosynostosis and a new model for midfacial hypoplasia.

  6. TILRR, an isoform encoded by an alternatively spliced FREM1 mRNA, is an IL-1RI co-receptor that associates with the signaling receptor complex to enhance recruitment of MyD88 (zeige MYD88 Antikörper) and control Ras-dependent amplification of NF-kappaB (zeige NFKB1 Antikörper) and inflammatory responses.

  7. Frem1 appears to act as a dermal mediator of basement membrane adhesion and is required for epidermal adhesion during embryonic development

  8. QBRICK is an adhesive ligand of basement membrane distinctively recognized by cells in the embryonic skin and hair follicles through different types of integrins directed to the Arg-Gly-Asp (zeige C3 Antikörper) motif.

  9. QBRICK/Frem1, Fras1 (zeige FRAS1 Antikörper), and Frem2 (zeige FREM2 Antikörper) interactions at the basement membrane have roles in preventing Fraser syndrome-like defects

  10. Taken together, our findings indicate that besides a cooperative function with Fras1 (zeige FRAS1 Antikörper) in embryonic basement membranes, Frem1 can also act independently in processes related to epidermal differentiation.

FRAS1 Related Extracellular Matrix 1 (FREM1) Antigen-Profil

Protein Überblick

This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon\; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation.

Genbezeichner und Symbole assoziert mit FREM1

  • FRAS1 related extracellular matrix 1 (FREM1) Antikörper
  • Fras1 related extracellular matrix 1 (Frem1) Antikörper
  • Fras1 related extracellular matrix protein 1 (Frem1) Antikörper
  • BC037594 Antikörper
  • BNAR Antikörper
  • C9orf143 Antikörper
  • C9orf145 Antikörper
  • C9orf154 Antikörper
  • D430009N09 Antikörper
  • D630008K06 Antikörper
  • eye Antikörper
  • eyes2 Antikörper
  • heb Antikörper
  • MOTA Antikörper
  • qbrick Antikörper
  • RGD1306981 Antikörper
  • TILRR Antikörper
  • TRIGNO2 Antikörper

Bezeichner auf Proteinebene für FREM1

FRAS1-related extracellular matrix protein 1 , extracellular matrix protein QBRICK

GENE ID SPEZIES
158326 Homo sapiens
481547 Canis lupus familiaris
298185 Rattus norvegicus
329872 Mus musculus
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