anti-F-Box Protein 4 (FBXO4) Antikörper

FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Zusätzlich bieten wir Ihnen F-Box Protein 4 Kits (12) und F-Box Protein 4 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
FBXO4 26272 Q9UKT5
FBXO4 106052 Q8CHQ0
FBXO4 310363  
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Top anti-F-Box Protein 4 Antikörper auf antikoerper-online.de

Showing 10 out of 90 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-FBXO4 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>293T cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-FBXO4 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>OVCAR-3 cell lysate WB Suggested Anti-FBXO4 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 <br /> Positive Control: OVCAR-3 cell lysate <br /> FBXO4 is supported by BioGPS gene expression data to be expressed in OVCAR3 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of FBXO4 Antibody (Center) (ABIN653243) in Y79 cell line lysates (35 µg/lane). FBXO4 (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of FBXO4 Antibody (Center) in Y79 cell line lysates (35ug/lane). FBXO4 (arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert WB Whole cell extracts prepared from U2OS cells, or insect Sf9 cells expressing DYKDDDDK-FBX4, were resolved by SDS-PAGE and transferred to nitrocellulose. FBX4 was detected using anti-FBX4 at a 1:500 dilution, in TBS buffer containing 0.1% Tween-20, followed by peroxidase conjugated anti-rabbit IgG. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$379.00
Details
Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$221.76
Details
Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$326.89
Details
Rind (Kuh) Ziege Unkonjugiert ELISA   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$317.63
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cells, using FBXO4 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$323.13
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details

FBXO4 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-F-Box Protein 4 Antikörper

  1. Human Polyclonal FBXO4 Primary Antibody für WB - ABIN233769 : Pontano, Aggarwal, Barbash, Brown, Bassing, Diehl: Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. in Molecular and cellular biology 2008 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal FBXO4 Primary Antibody für EIA, WB - ABIN952288 : Zeng, Wang, Yang, Chen, Yang, Diehl, Liu, Lei: Structural basis of selective ubiquitination of TRF1 by SCFFbx4. in Developmental cell 2010 (PubMed)
    Show all 3 Pubmed References

  3. Cow (Bovine) Polyclonal FBXO4 Primary Antibody für ELISA - ABIN4271628 : Barbash, Zamfirova, Lin, Chen, Yang, Nakagawa, Lu, Rustgi, Diehl: Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. in Cancer cell 2008 (PubMed)

  4. Cow (Bovine) Polyclonal FBXO4 Primary Antibody für WB - ABIN2774698 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007 (PubMed)

Weitere Antikörper gegen F-Box Protein 4 Interaktionspartner

Human F-Box Protein 4 (FBXO4) Interaktionspartner

  1. results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 (zeige CCND1 Antikörper) degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 (zeige CCND1 Antikörper) expression in human cancers.

  2. The FBXO4 I377M mutant exhibits impaired cyclin D1 recruitment and ubiquitylation.

  3. 14-3-3varepsilon binds to Ser12-phosphorylated Fbx4 to mediate dimerization and function.

  4. Biochemical studies indicate that both the N-terminal domain and a loop connecting the linker and C-terminal domain of Fbx4 are critical for the dimerization and activation of the protein.

  5. results reveal an atypical small GTPase (zeige RACGAP1 Antikörper) domain within Fbx4 as a substrate-binding motif for SCF (zeige KITLG Antikörper)(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 (zeige TERF1 Antikörper) in telomere homeostasis control

  6. Fbx4 is a central regulator of Pin2/TRF1 (zeige TERF1 Antikörper) protein abundance and alterations in the stability of Pin2/TRF1 (zeige TERF1 Antikörper) can have a dramatic impact on telomere length

  7. SCF (zeige KITLG Antikörper)(FBX4-alphaB crystallin (zeige CRYAB Antikörper)) is an E3 ubiquitin ligase (zeige MUL1 Antikörper) that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1 (zeige CCND1 Antikörper).

  8. Mutations in Fbx4 inhibit dimerization of the SCF (zeige KITLG Antikörper)(Fbx4) ligase and contribute to cyclin D1 (zeige CCND1 Antikörper) overexpression in human cancer.

Mouse (Murine) F-Box Protein 4 (FBXO4) Interaktionspartner

  1. Collectively, our data support a role for FBXO4 as a suppressor of esophageal tumorigenesis

  2. This study demonstrates that Fbxo4 deficiency induces Braf-driven melanoma and that this phenotype depends on cyclin D1 accumulation in mice, underscoring the importance of this ubiquitin ligase in tumor suppression.

  3. Fbx4 expression is essential for cell homeostasis in somatic cells. Fbx4 ablation predisposes mice to multiple tumor phenotypes, with concomitant cyclin D1 (zeige CCND1 Antikörper) deregulation and nuclear accumulation

  4. SCF (zeige KITLG Antikörper)(FBX4-alphaB crystallin (zeige CRYAB Antikörper)) is an E3 ubiquitin ligase (zeige MUL1 Antikörper) that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1 (zeige CCND1 Antikörper).

  5. Lysine 269 is essential for cyclin D1 (zeige CCND1 Antikörper) ubiquitylation by the SCF (zeige KITLG Antikörper)(Fbx4/alphaB-crystallin (zeige CRYAB Antikörper)) ligase.

F-Box Protein 4 (FBXO4) Antigen-Profil

Protein Überblick

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.

Genbezeichner und Symbole assoziert mit FBXO4

  • F-box protein 4 (FBXO4) Antikörper
  • F-box protein 4 (Fbxo4) Antikörper
  • F-box protein 4 (fbxo4) Antikörper
  • F-box protein 4 L homeolog (fbxo4.L) Antikörper
  • 1700096C12Rik Antikörper
  • AI851261 Antikörper
  • AW494535 Antikörper
  • fbx4 Antikörper
  • FBXO4 Antikörper
  • si:dkey-46a10.2 Antikörper

Bezeichner auf Proteinebene für FBXO4

F-box only protein 4 , F-box protein Fbx4 , F-box protein 4 , F-box only protein 4-like

GENE ID SPEZIES
26272 Homo sapiens
106052 Mus musculus
310363 Rattus norvegicus
431586 Gallus gallus
489220 Canis lupus familiaris
534852 Bos taurus
548694 Xenopus (Silurana) tropicalis
697007 Macaca mulatta
737372 Pan troglodytes
100158284 Xenopus laevis
100406305 Callithrix jacchus
100600195 Nomascus leucogenys
100194812 Salmo salar
101116349 Ovis aries
100735926 Cavia porcellus
100319387 Danio rerio
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