anti-FAT Tumor Suppressor Homolog 1 (Drosophila) (FAT1) Antikörper

FAT1 is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. Zusätzlich bieten wir Ihnen und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
FAT1 2195 Q14517
FAT1 14107  
FAT1    
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Top anti-FAT Tumor Suppressor Homolog 1 (Drosophila) Antikörper auf antikoerper-online.de

Showing 10 out of 47 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry: FAT1 Antibody [NBP1-84565] - Staining of human placenta shows strong cytoplasmic positivity in Decidual cells. Immunohistochemistry-Paraffin: FAT1 Antibody  - Staining of human rectum shows moderate cytoplasmic positivity in glandular cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$439.69
Details
Human Kaninchen Unkonjugiert WB Western Blot: FAT1 Antibody [NBP2-32274] - Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-FAT1 antibody NBP2-32274 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$486.94
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Human Kaninchen Unkonjugiert ICC, WB   100 μL Anmelden zum Anzeigen 13 bis 16 Tage
$275.00
Details
Human Kaninchen Unkonjugiert WB Western Blot: FAT1 Antibody [NBP2-32275] - Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-FAT1 antibody NBP2-32275 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$486.94
Details
Human Maus Unkonjugiert WB Human recombinant protein at 20 µg per lane, probed with bsm-51354M FAT1 (1634CT464.1.9) Monoclonal Antibody at 1:2000 dilution and 4℃ overnight incubation, followed by secondary antibody incubation for 60min at room temperature. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$291.50
Details
Fruchtfliege Maus Unkonjugiert ELISA, ICC, IF, IHC, WB   0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$317.63
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Human Maus Unkonjugiert   0.05 mL Anmelden zum Anzeigen 2 bis 3 Tage
$171.88
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Fruchtfliege Maus DyLight 488 ELISA, ICC, IF, WB   0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$408.19
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Fruchtfliege Maus Alexa Fluor 647 ELISA, ICC, IF, WB   0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$408.19
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Fruchtfliege Maus Alexa Fluor 700 ELISA, ICC, IF, WB   0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$408.19
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FAT1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , ,
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Mouse (Murine) ,


Fruit Fly (Drosophila melanogaster) ,


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Am meisten referenzierte anti-FAT Tumor Suppressor Homolog 1 (Drosophila) Antikörper

  1. Human Polyclonal FAT1 Primary Antibody für IHC, IHC (p) - ABIN4310665 : Morris, Kaufman, Gong, Ramaswami, Walsh, Turcan, Eng, Kannan, Zou, Peng, Banuchi, Paty, Zeng, Vakiani, Solit, Singh, Ganly, Liau, Cloughesy, Mischel, Mellinghoff, Chan: Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. in Nature genetics 2013 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal FAT1 Primary Antibody für IHC, IHC (p) - ABIN4310666 : Caruso, Herberth, Bartoli, Puppo, Dumonceaux, Zimmermann, Denadai, Lebossé, Roche, Geng, Magdinier, Attarian, Bernard, Maina, Levy, Helmbacher: Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy. in PLoS genetics 2013 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen FAT Tumor Suppressor Homolog 1 (Drosophila) Interaktionspartner

Human FAT Tumor Suppressor Homolog 1 (Drosophila) (FAT1) Interaktionspartner

  1. Disruption of MAPK/ERK (zeige MAPK1 Antikörper) pathway by FAT1 contributes the epithelial mesenchymal transformation in esophageal squamous cell carcinomas.

  2. Loss of function mutations in FAT1 and CASP8 (zeige CASP8 Antikörper) prevent cell adhesion and promote cell migration and proliferation in oral squamous cell carcinoma cell lines.

  3. We identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1 (zeige GPS1 Antikörper)) and FAT1

  4. FAT1 and mAb198.3 may offer new therapeutic opportunities for CRC (zeige CALR Antikörper).

  5. Data show that the two N-terminal SH3 domains of SH3 domain containing ring finger 1 (SH3RF1 (zeige SH3RF1 Antikörper)) protein interact with FAT1 protein.

  6. At the molecular level, under hypoxia the FAT1 depletion-associated reduction in HIF1alpha (zeige HIF1A Antikörper) was due to compromised EGFR (zeige EGFR Antikörper)-Akt (zeige AKT1 Antikörper) signaling as well as increased VHL (zeige VHL Antikörper)-dependent proteasomal degradation of HIF1alpha (zeige HIF1A Antikörper).

  7. Low FAT1 expression was associated with poor prognosis in children with medulloblastoma. Furthermore, FAT1 may act on Wnt (zeige WNT2 Antikörper) signaling pathway to exert its antitumor effect

  8. Recessive mutations in FAT1 cause a distinct renal disease entity in four families with a combination of steroid-resistance nephrotic syndrome, tubular ectasia, haematuria and facultative neurological involvement.

  9. that loss of FAT1 and beta-catenin (zeige CTNNB1 Antikörper) are associated with breast cancer progression, aggressive behavior, and poor prognosis

  10. FAT1 protein acts upstream of Hippo signalling through TAZ (zeige TAZ Antikörper) protein to regulate neuronal differentiation.

Mouse (Murine) FAT Tumor Suppressor Homolog 1 (Drosophila) (FAT1) Interaktionspartner

  1. studies suggest that Fat1 controls mitochondrial activity to restrain cell growth during the reparative, proliferative state induced by vascular injury. Given recent reports linking Fat1 to cancer, abnormal kidney and muscle development, and neuropsychiatric disease, this Fat1 function may have importance in other settings of altered cell growth and metabolism

  2. Fat1 deletion in podocytes induces abnormal glomerular filtration barrier development leading to podocyte foot process effacement. Fat1 knockdown in renal tubular cells reduces migration, decreases active RAC1/CDC42 (zeige CDC42 Antikörper) and induces defects in lumen formation.

  3. Fat1 interacts with Fat4 (zeige FAT4 Antikörper) to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development.

  4. Fat-1 expression suppresses CD4 (zeige CD4 Antikörper)+ T-cell activation and differentiation in spleen, and reduces inflammatory cytokines and eotaxin (zeige CCL11 Antikörper) in bronchoalveolar lavage and lung tissues of mice.

  5. Endogenous synthesis of n-3 PUFA in the fat-1 mouse attains similar kidney n-3 PUFA composition and eicosanoid levels as compared to fish oil feeding.

  6. FAT1 suppression in activated hepatic stellate cells caused a downregulation of NFkappaB activity

  7. Data find that Fat1 and Fat4 (zeige FAT4 Antikörper) cooperate during mouse development to control renal tubular elongation, cochlear extension, cranial neural tube formation and patterning of outer hair cells in the cochlea.

  8. results confirm a necessary role for FAT1 in the modified adhesion junctions of the renal glomerular epithelial cell and reveal hitherto unsuspected roles for FAT1 in CNS development

  9. Fat1 regulates actin cytoskeletal organization at cell peripheries, thereby modulating cell contacts and polarity.

  10. data are compatible with conservation and sub-functionalization of dachsous 1 (zeige DCHS1 Antikörper), Fj, and Fat signaling in higher vertebrates.

Pig (Porcine) FAT Tumor Suppressor Homolog 1 (Drosophila) (FAT1) Interaktionspartner

  1. these data provide new insights into the mechanisms of the association between FAT1 and porcine cumulus cell apoptosis.

FAT Tumor Suppressor Homolog 1 (Drosophila) (FAT1) Antigen-Profil

Protein Überblick

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and\\/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and\\/or alternative promoter usage exist, but they have not been fully described.

Genbezeichner und Symbole assoziert mit FAT1

  • FAT atypical cadherin 1 (FAT1) Antikörper
  • FAT atypical cadherin 1 (Fat1) Antikörper
  • FAT tumor suppressor homolog 1 (Drosophila) (FAT1) Antikörper
  • protocadherin Fat 1 (LOC100175143) Antikörper
  • FAT atypical cadherin 1 (fat1) Antikörper
  • 2310038E12Rik Antikörper
  • AU023433 Antikörper
  • CDHF7 Antikörper
  • CDHR8 Antikörper
  • FAT Antikörper
  • FAT1 Antikörper
  • Fath Antikörper
  • hFat1 Antikörper
  • ME5 Antikörper
  • mFat1 Antikörper

Bezeichner auf Proteinebene für FAT1

FAT tumor suppressor 1 , FAT tumor suppressor homolog 1 , cadherin ME5 , cadherin family member 7 , cadherin-related family member 8 , cadherin-related tumor suppressor homolog , protein fat homolog , protocadherin Fat 1 , fat 1 cadherin , FAT tumor suppressor homolog 1 (Drosophila) , fat1-like , protocadherin Fat 1-like

GENE ID SPEZIES
2195 Homo sapiens
14107 Mus musculus
395168 Gallus gallus
475621 Canis lupus familiaris
508251 Bos taurus
703034 Macaca mulatta
760178 Strongylocentrotus purpuratus
100050525 Equus caballus
100154043 Sus scrofa
100175143 Ciona intestinalis
100407761 Callithrix jacchus
100471195 Ailuropoda melanoleuca
100489070 Xenopus (Silurana) tropicalis
100549464 Meleagris gallopavo
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