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ECM1 encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. Zusätzlich bieten wir Ihnen ECM1 Antikörper (92) und ECM1 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.
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our work has identified a novel function of ECM1 in inhibiting Th17 cell differentiation in the experimental autoimmune encephalomyelitis model
ECM1, which displayed a high expression in hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) specimens, was closely associated with clinicopathologic data and may promote migration and invasion of HCC (zeige FAM126A ELISA Kits) cells by inducing epithelia-mesenchymal transition.
Cell invasion (matrigel) was reduced only in the Hs578T cells (p < 0.01). Silencing decreased the expression of the prometastatic molecules S100A4 (zeige S100A4 ELISA Kits) and TGFbetaR2 in both cell lines and CD44 (zeige CD44 ELISA Kits) in Hs578T cells. We conclude that ECM1 is a key player in the metastatic process and regulates the actin cytoskeletal architecture of aggressive breast cancer cells at least in part via alterations in S100A4 (zeige S100A4 ELISA Kits) and Rho A (zeige RHOA ELISA Kits).
Overexpression of miR (zeige MLXIP ELISA Kits)-486-3p inhibited cell growth and metastasis by targeting ECM1.
For 1q21 loci, we confirmed gene ECM1 as the most plausible gene from this region to be involved in pathogenesis of inflammatory bowel disease
In conclusion, the domain-specific anti-ECM1 MAbs produced in this study should provide a useful tool for investigating ECM1's biological functions, and cellular pathways in which it is involved.
Lipoid proteinosis is a rare autosomal recessive disorder caused by mutations in ECM1, encoding extracellular matrix protein 1, a glycoprotein expressed in many organs and which has important protein-protein interactions in tissue homeostasis
MMP-2 (zeige MMP2 ELISA Kits) protein and ECM1 gene are useful preoperative markers for defining malignancy in suspicious thyroid nodules
association between beta-catenin (zeige CTNNB1 ELISA Kits) and the MUC1 (zeige MUC1 ELISA Kits) cytoplasmic tail was increased by ECM1
Lipoidproteinosis results from a large homozygous deletion of ECM1 gene in a Chinese family.
ECM1 seems to be critical for PTHrP (zeige PTHLH ELISA Kits) action in chondrogenesis, as blockage of ECM1 nearly abolishes PTHrP (zeige PTHLH ELISA Kits) regulation of chondrocyte hypertrophy, and overexpression of ECM1 rescues disorganized growth plates of PTHrP (zeige PTHLH ELISA Kits)-null mice; ECM1 and progranulin (zeige GRN ELISA Kits) chondrogenic growth factor constitute an interaction network.
HA accumulation primes the vasculature for atherosclerosis by crosslinking and reorganizing the extracellular matrix (ECM (zeige MMRN1 ELISA Kits)) and by pushing VSMC differentiation towards a less mature phenotype.
Retinoid signaling in the stroma activates expression of Ecm1, which in turn down-regulates Ret (zeige RET ELISA Kits) expression in the ureteric bud cleft, where bifurcation normally occurs and normal branching progresses.
This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.
extracellular matrix protein 1
, secretory component p85