Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. Zusätzlich bieten wir Ihnen ESPL1 Antikörper (204) und und viele weitere Produktgruppen zu diesem Protein an.
Showing 3 out of 8 products:
Studies identified and characterized the role of separase in mitosis, meiosis, non-canonical roles, its regulation, as a regulator of centriole disengagement, non proteolytic roles, diverse substrates, structural insights, and association of separase with cancer. [review]
High ESP expression is associated with breast cancer.
Proximity mapping of human separase has been presented.
The assay was used to quantify Separase proteolytic activity in leukemic cell lines and peripheral blood samples from leukemia patients.
Recruitment and activation of separase at centrosomes are two distinct steps that do not require microtubules.
Separase protein levels decrease and Separase proteolytic activity increases exclusively in b3a2 p210BCR-ABL (zeige ABL1 ELISA Kits)-positive cell lines under Imatinib treatment.
Separase is an oncogene (zeige RAB1A ELISA Kits) whose overexpression induces tumorigenesis, and indicate that Separase overexpression and aberrant nuclear localization are common in many tumor types and may predict outcome in some human malignancies.
High ESPL1 mRNA expression was associated with luminal B breast cancers.
Data indicate that separase is subject to native-state cis (zeige CISH ELISA Kits)/trans isomerization by peptidyl-prolyl-isomerase (zeige PPI ELISA Kits) Pin1 (zeige PIN1 ELISA Kits).
Mutation of the homologous position in PTTG1 (zeige PTTG1 ELISA Kits) (H(134)) switched PTTG1 (zeige PTTG1 ELISA Kits) from an inhibitor into an activator of ESP1 (zeige AES ELISA Kits).
Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway.
Separase-overexpressing mammary cells are not only susceptible to chromosomal missegregation-induced aneuploidy but also other genetic instabilities
With the continual loss of cohesins from chromosomes that occurs throughout the natural reproductive lifespan, tight regulation of separase in oocytes may be particularly important to maintain cohesion and prevent aneuploidy.
Separase act synergistically with loss of p53 (zeige TP53 ELISA Kits) in the initiation and progression of B- and T- cell lymphomas
Separase phospho-regulation is critical for genome stability in oogenesis.
Separase phosphorylation act redundantly to prevent sister chromatid separation.
In embryonic fibroblasts, Separase depletion blocks sister chromatid separation but does not prevent other aspects of mitosis, cytokinesis, or chromosome replication.
Proteolytic activity of separase is therefore essential for Rec8 (zeige REC8 ELISA Kits)'s removal from chromosome arms and for chiasma resolution but not for PBE (zeige EHHADH ELISA Kits).
inhibitory phosphorylation of separase plays a critical role in the maintenance of sister chromatid cohesion and genome stability in proliferating postmigratory primordial germ cells
These results collectively suggest that Separase is an oncogene (zeige RAB1A ELISA Kits), whose overexpression alone in mammary epithelial cells is sufficient to induce aneuploidy and tumorigenesis in a p53 (zeige TP53 ELISA Kits) mutant background.
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21\; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009
extra spindle poles like 1
, caspase-like protein ESPL1
, extra spindle poles-like 1 protein
, separin, cysteine protease
, Cut1/ESP1 related protein