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Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. Zusätzlich bieten wir Ihnen ESPL1 Kits (8) und und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 204 products:
Human Monoclonal ESPL1 Primary Antibody für IHC (p), ELISA - ABIN564183
Zhang, Ge, Meyer, Sethi, Basu, Pradhan, Zhao, Li, Cai, El-Naggar, Baladandayuthapani, Kittrell, Rao, Medina, Pati: Overexpression of Separase induces aneuploidy and mammary tumorigenesis. in Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Monoclonal ESPL1 Primary Antibody für ICC, IF - ABIN151796
Chestukhin, DeCaprio: Western blot screening for monoclonal antibodies against human separase. in Journal of immunological methods 2003
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Monoclonal ESPL1 Primary Antibody für IF - ABIN534070
Chestukhin, Pfeffer, Milligan, DeCaprio, Pellman: Processing, localization, and requirement of human separase for normal anaphase progression. in Proceedings of the National Academy of Sciences of the United States of America 2003
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Human Monoclonal ESPL1 Primary Antibody für WB - ABIN151894
Sun, Kucej, Fan, Yu, Sun, Zou: Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner. in Cell 2009
Human Polyclonal ESPL1 Primary Antibody für DB, IHC (p) - ABIN389654
Haaß, Stehle, Nittka, Giehl, Schrotz-King, Fabarius, Hofmann, Seifarth: The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib. in PLoS ONE 2012
Studies identified and characterized the role of separase in mitosis, meiosis, non-canonical roles, its regulation, as a regulator of centriole disengagement, non proteolytic roles, diverse substrates, structural insights, and association of separase with cancer. [review]
High ESP expression is associated with breast cancer.
Proximity mapping of human separase has been presented.
The assay was used to quantify Separase proteolytic activity in leukemic cell lines and peripheral blood samples from leukemia patients.
Recruitment and activation of separase at centrosomes are two distinct steps that do not require microtubules.
Separase protein levels decrease and Separase proteolytic activity increases exclusively in b3a2 p210BCR-ABL (zeige ABL1 Antikörper)-positive cell lines under Imatinib treatment.
Separase is an oncogene (zeige RAB1A Antikörper) whose overexpression induces tumorigenesis, and indicate that Separase overexpression and aberrant nuclear localization are common in many tumor types and may predict outcome in some human malignancies.
High ESPL1 mRNA expression was associated with luminal B breast cancers.
Data indicate that separase is subject to native-state cis (zeige CISH Antikörper)/trans isomerization by peptidyl-prolyl-isomerase Pin1 (zeige PIN1 Antikörper).
Mutation of the homologous position in PTTG1 (zeige PTTG1 Antikörper) (H(134)) switched PTTG1 (zeige PTTG1 Antikörper) from an inhibitor into an activator of ESP1 (zeige AES Antikörper).
Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway.
Separase-overexpressing mammary cells are not only susceptible to chromosomal missegregation-induced aneuploidy but also other genetic instabilities
With the continual loss of cohesins from chromosomes that occurs throughout the natural reproductive lifespan, tight regulation of separase in oocytes may be particularly important to maintain cohesion and prevent aneuploidy.
Separase act synergistically with loss of p53 (zeige TP53 Antikörper) in the initiation and progression of B- and T- cell lymphomas
Separase phospho-regulation is critical for genome stability in oogenesis.
Separase phosphorylation act redundantly to prevent sister chromatid separation.
In embryonic fibroblasts, Separase depletion blocks sister chromatid separation but does not prevent other aspects of mitosis, cytokinesis, or chromosome replication.
Proteolytic activity of separase is therefore essential for Rec8 (zeige REC8 Antikörper)'s removal from chromosome arms and for chiasma resolution but not for PBE (zeige EHHADH Antikörper).
inhibitory phosphorylation of separase plays a critical role in the maintenance of sister chromatid cohesion and genome stability in proliferating postmigratory primordial germ cells
These results collectively suggest that Separase is an oncogene (zeige RAB1A Antikörper), whose overexpression alone in mammary epithelial cells is sufficient to induce aneuploidy and tumorigenesis in a p53 (zeige TP53 Antikörper) mutant background.
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21\; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009
extra spindle poles like 1
, caspase-like protein ESPL1
, extra spindle poles-like 1 protein
, separin, cysteine protease
, Cut1/ESP1 related protein