anti-Extra Spindle Poles Like 1 (ESPL1) Antikörper

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. Zusätzlich bieten wir Ihnen ESPL1 Kits (8) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ESPL1 9700 Q14674
ESPL1 315330  
ESPL1 105988 P60330
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Top anti-ESPL1 Antikörper auf antikoerper-online.de

Showing 10 out of 204 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, IHC (p) 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Maus Unkonjugiert WB Separase detected in 5C6 cell lysates using ABIN151894. Lane 1: Non-induced lysate. Lane 2: Lysate induced with ponasterone. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
291,00 €
Details
Human Kaninchen Unkonjugiert DB, IHC (p) Dot blot analysis of anti-hSeparase-S801 Phospho-specific Pab (ABIN389654) on nitrocellulose membrane.  50 ng of nonphospho-peptide or phospho-peptide were adsorbed on their respective dots. Antibody working concentration was 0.5 µg/mL. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Maus Unkonjugiert ICC, IF Overlay [blue] of centrosomal staining in HeLa cells. Centrosomal staining of separase [yellow], using ABIN151796, and gamma tubulin [green] in mitotic-metaphase cells and nuclear staining of separase in pre-mitotic cells. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
291,00 €
Details
Human Kaninchen Unkonjugiert IF, IHC, ELISA, WB Western blot analysis of extracts from 293 cells, treated with EGF 200ng/ml 30', using SEPARASE (Ab-801) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using SEPARASE (Ab-801) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB 100 μL Anmelden zum Anzeigen 13 Days
154,33 €
Details
Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB Western Blot (WB) analysis of specific cells using Separase Polyclonal Antibody. 100 μL Anmelden zum Anzeigen 13 Days
154,33 €
Details
Human Kaninchen Unkonjugiert WB Detection of ESPL1 isoforms 1 and 2 in A431 whole cell lysates using ABIN259875. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
291,00 €
Details
Human Kaninchen Unkonjugiert IF, IHC, ELISA, WB Western blot analysis of extracts from 293 cells treated with EGF 200ng/ml 30', using SEPARASE (Phospho-Ser801) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using SEPARASE (Phospho-Ser801) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Human Maus Unkonjugiert IHC (p), ELISA, WB ESPL1 monoclonal antibody (M01), clone 6H6 Western Blot analysis of ESPL1 expression in Hela S3 NE . Immunoperoxidase of monoclonal antibody to ESPL1 on formalin-fixed paraffin-embedded human prostate. [antibody concentration 3 ug/ml] 100 μg Anmelden zum Anzeigen 7 bis 8 Tage
369,60 €
Details

ESPL1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-ESPL1 Antikörper

  1. Human Monoclonal ESPL1 Primary Antibody für IHC (p), ELISA - ABIN564183 : Zhang, Ge, Meyer, Sethi, Basu, Pradhan, Zhao, Li, Cai, El-Naggar, Baladandayuthapani, Kittrell, Rao, Medina, Pati: Overexpression of Separase induces aneuploidy and mammary tumorigenesis. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 7 Pubmed References

  2. Human Monoclonal ESPL1 Primary Antibody für ICC, IF - ABIN151796 : Chestukhin, DeCaprio: Western blot screening for monoclonal antibodies against human separase. in Journal of immunological methods 2003 (PubMed)
    Show all 6 Pubmed References

  3. Monoclonal ESPL1 Primary Antibody für IF - ABIN534070 : Chestukhin, Pfeffer, Milligan, DeCaprio, Pellman: Processing, localization, and requirement of human separase for normal anaphase progression. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal ESPL1 Primary Antibody für DB, IHC (p) - ABIN389654 : Haaß, Stehle, Nittka, Giehl, Schrotz-King, Fabarius, Hofmann, Seifarth: The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib. in PLoS ONE 2012 (PubMed)

  5. Human Monoclonal ESPL1 Primary Antibody für WB - ABIN151894 : Sun, Kucej, Fan, Yu, Sun, Zou: Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner. in Cell 2009 (PubMed)

Weitere Antikörper gegen ESPL1 Interaktionspartner

Human Extra Spindle Poles Like 1 (ESPL1) Interaktionspartner

  1. Proximity mapping of human separase has been presented.

  2. The assay was used to quantify Separase proteolytic activity in leukemic cell lines and peripheral blood samples from leukemia patients.

  3. Recruitment and activation of separase at centrosomes are two distinct steps that do not require microtubules.

  4. Separase protein levels decrease and Separase proteolytic activity increases exclusively in b3a2 p210BCR-ABL (zeige ABL1 Antikörper)-positive cell lines under Imatinib treatment.

  5. Separase is an oncogene (zeige RAB1A Antikörper) whose overexpression induces tumorigenesis, and indicate that Separase overexpression and aberrant nuclear localization are common in many tumor types and may predict outcome in some human malignancies.

  6. High ESPL1 mRNA expression was associated with luminal B breast cancers.

  7. Data indicate that separase is subject to native-state cis (zeige CISH Antikörper)/trans isomerization by peptidyl-prolyl-isomerase Pin1 (zeige PIN1 Antikörper).

  8. Mutation of the homologous position in PTTG1 (zeige PTTG1 Antikörper) (H(134)) switched PTTG1 (zeige PTTG1 Antikörper) from an inhibitor into an activator of ESP1 (zeige AES Antikörper).

  9. By consecutively acting as a protease and a cdk1 (zeige CDK1 Antikörper) inhibitor, separase coordinates two key processes to achieve simultaneous and abrupt separation of sister chromatids.

  10. Kendrin (zeige PCNT Antikörper) is a novel and crucial substrate for separase (ESPL1) at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis.

Mouse (Murine) Extra Spindle Poles Like 1 (ESPL1) Interaktionspartner

  1. Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway.

  2. Separase-overexpressing mammary cells are not only susceptible to chromosomal missegregation-induced aneuploidy but also other genetic instabilities

  3. With the continual loss of cohesins from chromosomes that occurs throughout the natural reproductive lifespan, tight regulation of separase in oocytes may be particularly important to maintain cohesion and prevent aneuploidy.

  4. Separase act synergistically with loss of p53 (zeige TP53 Antikörper) in the initiation and progression of B- and T- cell lymphomas

  5. Separase phospho-regulation is critical for genome stability in oogenesis.

  6. Separase phosphorylation act redundantly to prevent sister chromatid separation.

  7. In embryonic fibroblasts, Separase depletion blocks sister chromatid separation but does not prevent other aspects of mitosis, cytokinesis, or chromosome replication.

  8. Proteolytic activity of separase is therefore essential for Rec8 (zeige REC8 Antikörper)'s removal from chromosome arms and for chiasma resolution but not for PBE (zeige EHHADH Antikörper).

  9. inhibitory phosphorylation of separase plays a critical role in the maintenance of sister chromatid cohesion and genome stability in proliferating postmigratory primordial germ cells

  10. These results collectively suggest that Separase is an oncogene (zeige RAB1A Antikörper), whose overexpression alone in mammary epithelial cells is sufficient to induce aneuploidy and tumorigenesis in a p53 (zeige TP53 Antikörper) mutant background.

ESPL1 Antigen-Profil

Protein Überblick

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21\; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009

Genbezeichner und Symbole assoziert mit ESPL1

  • extra spindle pole bodies homolog 1 (S. cerevisiae) (ESPL1) Antikörper
  • extra spindle poles like 1 (espl1) Antikörper
  • extra spindle pole bodies homolog 1 (S. cerevisiae) (Espl1) Antikörper
  • extra spindle poles-like 1 (S. cerevisiae) (Espl1) Antikörper
  • AL024103 Antikörper
  • AU045071 Antikörper
  • Cerp Antikörper
  • ESP1 Antikörper
  • mp:zf637-3-001691 Antikörper
  • PRCE Antikörper
  • SEPA Antikörper
  • SSE Antikörper

Bezeichner auf Proteinebene für ESPL1

extra spindle poles like 1 , cds , separase , cease&desist , zf637-3-001691 , caspase-like protein ESPL1 , extra spindle poles-like 1 protein , separin , separin, cysteine protease , Cut1/ESP1 related protein

GENE ID SPEZIES
100063779 Equus caballus
337864 Danio rerio
9700 Homo sapiens
425536 Gallus gallus
607879 Canis lupus familiaris
506740 Bos taurus
315330 Rattus norvegicus
105988 Mus musculus
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