Eukaryotic Translation Initiation Factor 4E (EIF4E) ELISA Kits

The protein encoded by EIF4E is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. Zusätzlich bieten wir Ihnen EIF4E Antikörper (257) und EIF4E Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
EIF4E 1977 P06730
EIF4E 13684 P63073
EIF4E 117045 P63074
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Weitere ELISA Kits für EIF4E Interaktionspartner

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. The structures of eIF4E-eIF4G (zeige EIF4G1 ELISA Kits) complexes reveal an extended interface to regulate translation initiation.

  2. Phosphorylation of 4E-BP1 (zeige EIF4EBP1 ELISA Kits) impairs the competition with eIF4G (zeige EIF4G1 ELISA Kits) for eIF4E binding.

  3. Both eIF4E-1 and eIF4E-3 (zeige EIF4E3 ELISA Kits) are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.

  4. eIF4E-binding protein (zeige EIF4EBP1 ELISA Kits) requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.

  5. Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.

  6. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.

  7. eIF4E regulates the sex-specific expression of the master switch gene Sxl.

  8. data are consistent with the idea that Parkin (zeige PARK2 ELISA Kits) and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events.

  9. results show that LK6 binds to ERK (zeige MAPK1 ELISA Kits) and is activated by ERK (zeige MAPK1 ELISA Kits) signalling and it is responsible for phosphorylating eIF4E in Drosophila

  10. our results suggest that the level of eIF4E protein is regulated by Diap1 (zeige DIAPH1 ELISA Kits), and that IAPs may play a role in cap-dependent translation by regulating the level of eIF4E protein.

Xenopus laevis Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.

  2. CDK1 (zeige CDK1 ELISA Kits) and calcineurin regulate Maskin (zeige TACC3 ELISA Kits) association with eIF4E and translational control of cell cycle progression

  3. CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T and eIF4E1b

Human Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. Mitogen-activated protein kinase (zeige MAPK1 ELISA Kits) interacting protein (zeige CIB1 ELISA Kits) kinases (Mnks) control translation by phosphorylation of eIF4E, whereas the mTOR (zeige FRAP1 ELISA Kits) kinase phosphorylates/de-activates the eIF4E inhibitor, 4E-BP1 (zeige EIF4EBP1 ELISA Kits), to release translational repression.

  2. Elevated levels of p-Mnk1 (zeige MKNK1 ELISA Kits), p-eIF4E and p-p70S6K (zeige RPS6KB1 ELISA Kits) proteins are associated with tumor recurrence and poor prognosis in astrocytomas. Overexpression of p-eIF4E and co-expression of p-Mnk1 (zeige MKNK1 ELISA Kits), p-eIF4E and p-p70S6K (zeige RPS6KB1 ELISA Kits) proteins could be used as novel independent poor prognostic biomarkers for patients with astrocytomas.

  3. PRMT1 (zeige PRMT1 ELISA Kits) inhibition prevents gastric cancer progression by downregulating eIF4E and targeting type II PRMT5 (zeige PRMT5 ELISA Kits).

  4. MNK-1 (zeige MKNK1 ELISA Kits) controls chemokine (zeige CCL1 ELISA Kits) secretion and proliferation in human airway smooth muscle cells.

  5. Data indicate that combinations of androgen receptor (AR (zeige AR ELISA Kits)) and mechanistic target of rapamycin (mTOR (zeige FRAP1 ELISA Kits)) inhibitors were effective in suppressing tumor growth including bicalutamide increased eukaryotic initiation factor 4E (eIF4E) phosphorylation.

  6. Study identified and established the presence of an evolutionarily conserved water-bridge structural module which is an integral component of the recognition of the 5' mRNA cap by eIF4E during the process of translation initiation.

  7. Here, the authors identify the domains responsible for the eIF4E/human rhinovirus 2 2A(pro) interaction using molecular modelling and describe mutations that impair this interaction and delay in vitro cleavage of eIF4G (zeige EIF4G1 ELISA Kits) isoforms.

  8. Results suggest that IGF2BP3 promotes eIF4E-mediated translational activation through the reduction of EIF4E-BP2 via mRNA degradation, leading to enhanced cell proliferation.

  9. There were significantly higher expressions of p-eIF4E and p-4EBP-1 (zeige EIF4EBP1 ELISA Kits) proteins in the cases with lymph node metastasis than in those without lymph node metastasis.

  10. Our studies provide the first biochemical framework for the eIF4E-dependent mRNA export pathway.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. Mitogen-activated protein kinase (zeige MAPK1 ELISA Kits) interacting protein (zeige CIB1 ELISA Kits) kinases (Mnks) control translation by phosphorylation of eIF4E, whereas the mTOR (zeige FRAP1 ELISA Kits) kinase phosphorylates/de-activates the eIF4E inhibitor, 4E-BP1 (zeige EIF4EBP1 ELISA Kits), to release translational repression.

  2. PRMT1 (zeige PRMT1 ELISA Kits) inhibition prevents gastric cancer progression by downregulating eIF4E and targeting type II PRMT5 (zeige PRMT5 ELISA Kits).

  3. Our work demonstrates that a single phosphorylation site on the 5' cap-binding protein eIF4E is a critical mechanism for changes in nociceptor excitability that drive the development of chronic pain.

  4. data suggest a physiological role for MNK1a-Ser (zeige SIGLEC1 ELISA Kits)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.

  5. Results of our study suggest that the eIF4E/Fmr1 (zeige FMR1 ELISA Kits) double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder.

  6. Our findings identify the eIF4E- beta-catenin (zeige CTNNB1 ELISA Kits) axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.

  7. Unphosphorylated HSP27 (zeige HSPB1 ELISA Kits) associates with eIF4E in osteoblasts and suppresses the translation initiation process.

  8. Rotenone induction of hydrogen peroxide inhibits mTOR (zeige FRAP1 ELISA Kits)-mediated S6K1 (zeige RPS6KB1 ELISA Kits) and 4E-BP1 (zeige EIF4EBP1 ELISA Kits)/eIF4E pathways, resulting in caspase (zeige CASP3 ELISA Kits)-dependent and -independent apoptosis in neuronal cells.

  9. Findings indicate eIF4E is maintained at levels in excess for normal development that are hijacked by cancer cells to drive a translational program supporting tumorigenesis.

  10. a light- and circadian clock-regulated MAPK (zeige MAPK1 ELISA Kits)/MNK (zeige ATP7A ELISA Kits) pathway led to phosphorylation of the cap-binding protein eIF4E

Pig (Porcine) Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaktionspartner

  1. These data suggest that sapovirus VPg can hijack the cellular translation initiation mechanism by recruiting the eIF4F (zeige EIF4A2 ELISA Kits) complex through a direct eIF4E interaction

  2. it is proposed that a balanced regulation of the truncation of the cap-binding complex component eIF4F (zeige EIF4A2 ELISA Kits) and degradation of 4E-BP1 (zeige EIF4EBP1 ELISA Kits) and/or truncation of 4E-BP2 (zeige EIF4EBP2 ELISA Kits) that together ensures correct translational control during the dynamic process of conceptus implantation

  3. Results show that in pigs, the truncated eIF4E is located in the endometrial luminal epithelium during implantation. Neither glandulary tissue nor stroma expressed any truncated eIF4E.

  4. The translation initiation in the endometrium is differently regulated by the two eIF4E forms with regard to different 4E-BP1 (zeige EIF4EBP1 ELISA Kits) abundance and phosphorylation as well as different eIF4E/4E-BP1 (zeige EIF4EBP1 ELISA Kits) binding dynamic depending on the type of implantation.

  5. Modified translational initiation of eIF4E may particularly regulate protein synthesis during conceptus attachment at the time of implantation in swine.

  6. Translation initiation factor eIF4E is phosphorylated during in vitro maturation of pig oocytes with a maximum in metaphase II stage oocytes.

EIF4E Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit EIF4E

  • Eukaryotic initiation factor 4E (eIF-4E) Antikörper
  • eucaryotic initiation factor 6 (eif6) Antikörper
  • eukaryotic translation initiation factor 4E (eif4e) Antikörper
  • eukaryotic translation initiation factor 4E family member 1B S homeolog (eif4e1b.S) Antikörper
  • eukaryotic translation initiation factor 4E (EIF4E) Antikörper
  • eukaryotic translation initiation factor 4E (Eif4e) Antikörper
  • eukaryotic translation initiation factor 4E L homeolog (eif4e.L) Antikörper
  • eukaryotic translation initiation factor 4ea (eif4ea) Antikörper
  • translation initiation factor eIF4E (LOC100533326) Antikörper
  • 2 Antikörper
  • 0260/09 Antikörper
  • 0587/11 Antikörper
  • 0589/11 Antikörper
  • 0919/12 Antikörper
  • 1004/13 Antikörper
  • 7238 Antikörper
  • AUTS19 Antikörper
  • cbp Antikörper
  • CG4035 Antikörper
  • CT13384 Antikörper
  • CT39424 Antikörper
  • CT39426 Antikörper
  • D-eIF4E Antikörper
  • deIF-4E Antikörper
  • deIF4E Antikörper
  • Dmel\\CG4035 Antikörper
  • EG668879 Antikörper
  • EIF-4E Antikörper
  • eIF-4E1 Antikörper
  • eIF-4E2 Antikörper
  • eIF-4EII Antikörper
  • eif4e Antikörper
  • eIF 4E Antikörper
  • eif4e-1 Antikörper
  • eIF4E-1/2 Antikörper
  • eIF4E-2 Antikörper
  • Eif4e-ps Antikörper
  • EIF4E1 Antikörper
  • eIF4EI Antikörper
  • EIF4EL1 Antikörper
  • EIF4F Antikörper
  • If4e Antikörper
  • l(3)07238 Antikörper
  • l(3)67Af Antikörper
  • l(3)S025007 Antikörper
  • l(3)S026009 Antikörper
  • l(3)S058711 Antikörper
  • l(3)S091912 Antikörper
  • zgc:86680 Antikörper

Bezeichner auf Proteinebene für EIF4E

CG4035-PA , CG4035-PB , CG4035-PC , CG4035-PD , CG4035-PE , CG4035-PF , CG4035-PG , CG4035-PH , CG4035-PI , cap binding protein , eIF-4E-PA , eIF-4E-PB , eIF-4E-PC , eIF-4E-PD , eIF-4E-PE , eIF-4E-PF , eIF-4E-PG , eIF-4E-PH , eIF-4E-PI , eukaryotic initiation factor 4E , eukaryotic translation initiation factor 4E , lethal(3)67Af , eucaryotic initiation factor6 , eIF4E , PCO081734 , PCO081734_ov , mRNA cap-binding protein , eukaryotic translation initiation factor small subunit , eIF-4F 25 kDa subunit , eIF-4E , eukaryotic translation initiation factor 4E-like 1 , elongation initiation factor 4E , eukaryotic translation initiation factor 4e 1a , eukaryotic translation initiation factor eIF4E-1

GENE ID SPEZIES
45525 Drosophila melanogaster
542608 Zea mays
548663 Xenopus (Silurana) tropicalis
399255 Xenopus laevis
1977 Homo sapiens
13684 Mus musculus
117045 Rattus norvegicus
422703 Gallus gallus
734259 Xenopus laevis
281751 Bos taurus
100009338 Oryctolagus cuniculus
487870 Canis lupus familiaris
100038030 Sus scrofa
79380 Danio rerio
100533326 Aplysia californica
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