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Transcriptional activator that binds to the enhancer of the adenovirus E1A gene\; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.. Zusätzlich bieten wir Ihnen ETV4 Antikörper (75) und ETV4 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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FOS strongly binds to the same MED25 (zeige MED9 ELISA Kits) site as ETV4 activation domain and JUN (zeige JUN ELISA Kits) interacts with the other two MED25 (zeige MED9 ELISA Kits) sites.
Our results indicate that assessing AP1 (zeige FOSB ELISA Kits) and PEA3 transcription factor status might be a good indicator of OAC status. However, we could not detect any associations with disease stage or patient treatment regime. This suggests that the PEA3-AP1 (zeige FOSB ELISA Kits) regulatory module more likely contributes more generally to the cancer phenotype. In keeping with this observation, depletion of ETV1 (zeige ETV1 ELISA Kits) and/or ETV4 causes an OAC cell growth defect
ETV4 overexpression is associated with lung cancer metastasis.
Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETV1, ETV4 and ETV5.
The data provide the molecular details of ETV4-mediated NANOG gene expression.
the prostate cancer-related oncogenic E26 transformation-specific (ETS (zeige ETS1 ELISA Kits)) transcription factors, ETV1 (zeige ETV1 ELISA Kits), ETV4, and ETV5, were required for TAZ (zeige TAZ ELISA Kits) gene transcription in PC3 (zeige PCSK1 ELISA Kits) prostate cancer cells
NCOA2ETV4 protein would contain the helixloophelix, PAS_9 and PAS_11, CITED domains, the SRC1 (zeige SRC ELISA Kits) domain of NCOA2 (zeige NCOA2 ELISA Kits) and the ETS (zeige ETS1 ELISA Kits) DNAbinding domain of ETV4.
PEA3-subgroup transcription factors are key players of the Met signaling integration involved in regulation of migration and invasiveness of tumor cells.
ACC1 (zeige ACACA ELISA Kits) and ACLY (zeige ACLY ELISA Kits) regulate the levels of ETV4 under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1 (zeige ACACA ELISA Kits)/ACLY (zeige ACLY ELISA Kits)-alpha-ketoglutarate-ETV4 axis is a novel means by which metabolic states regulate transcriptional output
ETV4 overexpression is associated with prostate cancer aggressiveness.
etv5a and etv4 have roles in mediating epithelial cell fate during zebrafish kidney development
Pea3 and erm are required for zebrafish pronephrogenesis and can functionally complement each other, and the wt1a gene may be one of their downstream targets.
Overlapping functions of pea3 ETS (zeige ETS1 ELISA Kits) transcription factors in FGF signaling during zebrafish development are reported.
Our results will help understand the mechanism of ETV4 overexpression in CRC (zeige SCRIB ELISA Kits) patients and provide a clue to search new therapeutic target to treat the related tumors in clinical practice.
ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells.
paracrine signaling via fibroblast growth factor 2 (Fgf2 (zeige FGF2 ELISA Kits)) and Mapk (zeige MAPK1 ELISA Kits) between these diverged tumor subclones causes enhanced expression of the Pea3 transcription factor, resulting in metastatic dissemination of the neuroendocrine tumor subclones.
Study hypothesized that PEA3 might play an essential role in the activation of the FAK (zeige PTK2 ELISA Kits) gene during tumor metastasis.
Study reveals molecular insight into how the Ets (zeige ETS1 ELISA Kits) family transcription factor Pea3 favors EMT (zeige ITK ELISA Kits) and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2 (zeige CCND2 ELISA Kits), a new Pea3 target gene.
oncogenic Etv4 promotes prostate cancer metastasis in response to coactivation of PI3-kinase and Ras signaling pathways in a genetically engineered model of highly penetrant, metastatic prostate cancer
PEA3-null fibroblasts exhibit impaired c-src activation and motility defects.
Smad2 (zeige SMAD2 ELISA Kits) and PEA3 regulate RGC-32 (zeige C13orf15 ELISA Kits) transcription which is essential for smooth muscle cell differentiation from neural crest cells.
study provides evidence for a protumorigenic role of PEA3 factors in breast neoplasia, and supports targeting the PEA3 transcription factor family in breast cancer
Induction of Pea3 gene expression by peripheral signals is required to coordinate the central position and terminal arborization of specific sets of spinal motor neurons.
Transcriptional activator that binds to the enhancer of the adenovirus E1A gene\; the core-binding sequence is 5'GT-3'.
ets variant 4
, ETS translocation variant gene 4
, ets variant gene 4 (E1A enhancer binding protein, E1AF)
, ets domain protein
, ETS translocation variant 4
, EWS protein/E1A enhancer binding protein chimera
, adenovirus E1A enhancer-binding protein
, ets variant gene 4 (E1A enhancer-binding protein, E1AF)
, polyomavirus enhancer activator 3 homolog
, ETS translocation variant 4-like
, polyomavirus enhancer activator-3
, ETS domain-containing transcription factor PEA3
, ETS-domain transcription factor pea3
, ETS variant protein 4
, POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3 PROTEIN) (ETS TRANSLOCATION VARIANT 4)