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EPX is a member of the peroxidase gene family and is expressed in eosinophils. Zusätzlich bieten wir Ihnen EPX Kits (26) und EPX Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.
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tyrosine phosphorylation of PMR1 (zeige ATP2C1 Antikörper) is required for the targeting and degradation of polyribosome-bound substrate mRNA
peroxidase enzymes, like MPO (zeige MPO Antikörper) and EPO (zeige EPO Antikörper), may play a fundamental role in inhibiting RANKL (zeige TNFSF11 Antikörper)-induced osteoclast differentiation at inflammatory sites of bone fracture and injury.
Both MPO (zeige MPO Antikörper) and EPO (zeige EPO Antikörper) are causatively involved in breast cancer progression and identified as potential therapeutic targets whereby specific novel inhibitors may reduce tumor growth and limit the occurrence of metastasis.
The main significance of this work is the discovery of EPO (zeige EPO Antikörper) as a novel ligand for the HER2 (zeige ERBB2 Antikörper) receptor. Following HER2 (zeige ERBB2 Antikörper) activation, EPO (zeige EPO Antikörper) induces activation of FAK (zeige PTK2 Antikörper) and subsequent activation of beta1-integrin, via inside-out signaling. This complex results in downstream activation of ERK1/2 (zeige MAPK1/3 Antikörper) and a sustained up regulation of both MUC4 (zeige MUC4 Antikörper) and the HER2 (zeige ERBB2 Antikörper) receptor
EPO (zeige EPO Antikörper)-mediated protein carbamylation is promoted during allergen-induced asthma exacerbation, and can both modulate immune responses and trigger a cascade of many of the inflammatory signals present in asthma.
there is a strong association in a given patient between both nasal and pharyngeal EPX levels and the eosinophil percentage of induced sputum.
Myeloperoxidase (zeige MPO Antikörper) and eosinophil peroxidase are readily internalized by HUVEC cells where they promote cellular proliferation, migration, invasion, and stimulate angiogenesis both in vitro and in vivo.
A preferential role of EPO (zeige EPO Antikörper) signaling via a specific surface receptor that leads to neural plasticity.
Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia.
report the prevalence of a common SNP in the eosinophil protein x/eosinophil-derived neurotoxin (zeige RNASE2 Antikörper) (EPX/EDN (zeige RNASE2 Antikörper), RNase2 (zeige RNASE2 Antikörper)) and the association with the cellular contents of EPX/EDN (zeige RNASE2 Antikörper) and ECP (zeige ECP Antikörper)
Polymorphisms of EPX and ECP (zeige ECP Antikörper) are associated to inflammatory bowel disease in an age and gender dependent manne.
The expression of MBP-1 (zeige ENO1 Antikörper) and EPX was also required for induced lung expression of IL-4 (zeige IL4 Antikörper)/IL-13 (zeige IL13 Antikörper) in each setting and, in turn, the induced pulmonary remodeling events and lung dysfunction.
The absence of MBP-1 (zeige ENO1 Antikörper) and EPX promoted a concomitant loss of eosinophil lineage-committed progenitors in the marrow, identifying a specific blockade in eosinophilopoiesis as the causative event.
HER2 (zeige ERBB2 Antikörper) was identified as a novel mediator of eosinophil peroxidase signaling. Eosinophil peroxidase, at noncytotoxic levels, can drive cell-cycle progression and proliferation.
Host protection against Brugia pahangi infections was unimpaired in mice deficient in eosinophil peroxidase.
Mice deficient for either eosinophil peroxidase or major basic protein on the 129/SvJ background developed significantly higher worm burdens than wild-type mice.
post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase
The activities of EPO (zeige EPO Antikörper), an eosinophilic secondary granule protein, do not affect the development of allergic pulmonary pathologies in the mouse lung at levels comparable to those observed in humans with asthma.
This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency.
, polysomal ribonuclease 1
, eosinophil peroxidase-like