anti-Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Antikörper

The protein encoded by ERAP1 is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. Zusätzlich bieten wir Ihnen ERAP1 Proteine (7) und ERAP1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ERAP1 51752 Q9NZ08
ERAP1 80898 Q9EQH2
ERAP1 80897 Q9JJ22
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Top anti-ERAP1 Antikörper auf antikoerper-online.de

Showing 10 out of 70 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB Western blot analysis of anti-ARTS1 Antibody (Center) (ABIN392336) in Ramos cell line lysates (35 µg/lane). ARTS1 (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from HepG2/Jurkat/HuvEc cells, using ARTS-1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Maus Unkonjugiert WB ARTS-1 monoclonal antibody (M01), clone 4H8 Western Blot analysis of ARTS-1 expression in A-431. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
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Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
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Human Kaninchen Unkonjugiert IF, IHC (p), WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IC, IF, IP, IHC, WB Immunofluorescent analysis of ERAP1 staining in NIH3T3 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of ERAP1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IHC (p)   50 μg Anmelden zum Anzeigen 12 bis 15 Tage
$440.00
Details
Human Kaninchen Unkonjugiert IHC (p) Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
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ERAP1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Human , , ,
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Mouse (Murine) ,


Rat (Rattus) ,


Weitere Antikörper gegen ERAP1 Interaktionspartner

Human Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Interaktionspartner

  1. ERAP1 and ERAP2 have significant and distinct effects on the HLA-B*27 peptidome, suggesting that both enzymes largely act as separate entities in vivo. This may explain their different patterns of association with AS.

  2. This review focuses on the ambivalent role of HLA-B27 in autoimmunity and viral protection correlating its functions to the quantitative and qualitative effects of ERAP1 and ERAP2 (zeige ERAP2 Antikörper) polymorphisms on their enzymatic activity.

  3. The ERAP1 gene polymorphism might be a risk factor in the pathogenesis of ankylosing spondylitis and inflammatory bowel disease. In contrast, IL-23R (zeige IL23R Antikörper) gene polymorphisms may serve a protective role in ankylosing spondylitis and inflammatory bowel disease.

  4. Our results suggest that normal levels of ERAP1 reduce the accumulation of aberrant and disulfide-linked forms of HLA-B27 in monocytes, and thus help to maintain the integrity of cell surface HLA-B27 complexes.

  5. The alterations in the nature and affinity of HLA-B*51.peptide complexes probably affect T-cell and natural killer cell recognition, providing a sound basis for the joint association of ERAP1 and HLA-B*51 with Behcet's disease.

  6. One ERAP1 protein allotype with five non-ancestral amino acids was recessively associated with Behcet's disease. The ERAP1 association was absent in individuals who lacked HLA-B*51. Individuals who carry HLA-B*51 and who are also homozygous for the haplotype had an increased disease odds compared with those with neither risk factor.

  7. Electrostatic interactions between domains II and IV in ERAP1 are crucial for driving a conformational change that regulates the structural integrity of the catalytic site.

  8. analysis of genotype and haplotype frequencies of four coding, nonsynonymous ERAP1 SNPs, rs26653G > C, rs26618T > C, rs30187C > T, and rs27044C > G, in non-small cell lung carcinoma occurring in two genetically distant populations, Chinese and Poles

  9. there is a significant association of ERAP2 with psoriatic arthritis and HLA-B27 negative psoriatic arthritis, while ERAP1 association is restricted only to HLA-B27 positive disease

  10. The ERAP1 rs27044/rs30187 haplotype C/T is associated with lower risk of extraspinal disease and systemic inflammation in Nordic AS patients but has no impact on IL-6 (zeige IL6 Antikörper) or TNF (zeige TNF Antikörper) levels.

Mouse (Murine) Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Interaktionspartner

  1. we have shown that the loss of ERAAP leads to shifts in the nature and lengths of peptides presented by MHC I molecules on the cell surface

  2. results suggest that several aminopeptidases play important roles in the maximum synthesis of NO in activated macrophages in a substrate peptide-dependent manner and ERAP1 is one of the aminopeptidases involved in the NO synthesis

  3. Data show that endoplasmic reticulum protein 44 (ERp44 (zeige ERP44 Antikörper)) forms a mixed disulfide bond with aminopeptidase (zeige ANPEP Antikörper) ERAP1 and controls the release of ERAP1 in a redox-dependent manner to control blood pressure.

  4. This study clarifies ERAP1's role in shaping immunodominance through creation and destruction of peptides in vivo and demonstrates the functional significance of ERAP1 in modulating T-cell killing based upon this role.

  5. These results suggest that secretion of ERAP1 is mediated by toll (zeige TLR4 Antikörper)-like receptors via induction of intermediate cytokines

  6. ERAP1 directly alters peptide binding and presentation by HLA-B27, thus demonstrating a potential pathogenic mechanism in ankylosing spondylitis.

  7. Absence of Tpn or ERAAP independently altered the peptide repertoire by causing loss as well as gain of new pMHC I. ERAAP defined the characteristic amino termini of canonical MHC I peptides.

  8. MHC class Ib-restricted cytolytic effector cells specifically eliminated ERAAP-deficient cells in vitro and in vivo.

  9. endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma (zeige IFNG Antikörper)

  10. ERAAP silencing results in MHC-I peptide-loading defects eliciting rejection of the murine T-cell lymphoma RMA in syngeneic mice

ERAP1 Antigen-Profil

Protein Überblick

The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit ERAP1

  • endoplasmic reticulum aminopeptidase 1 (ERAP1) Antikörper
  • endoplasmic reticulum aminopeptidase 1 (erap1) Antikörper
  • endoplasmic reticulum aminopeptidase 1b (erap1b) Antikörper
  • endoplasmic reticulum aminopeptidase 1 (Erap1) Antikörper
  • A-LAP Antikörper
  • ALAP Antikörper
  • Appils Antikörper
  • ARTS-1 Antikörper
  • Arts1 Antikörper
  • DKFZp469C044 Antikörper
  • ERAAP Antikörper
  • ERAAP1 Antikörper
  • MGC166160 Antikörper
  • PILS-AP Antikörper
  • PILSA Antikörper
  • PILSAP Antikörper

Bezeichner auf Proteinebene für ERAP1

endoplasmic reticulum aminopeptidase 1 , endoplasmic reticulum aminopeptidase 1-like , type 1 tumor necrosis factor receptor shedding aminopeptidase regulator , adipocyte-derived leucine aminopeptidase , aminopeptidase PILS , aminopeptidase regulator of TNFR1 shedding , endoplasmic reticulum aminopeptidase associated with antigen processing , puromycin-insensitive leucyl-specific aminopeptidase , A-LAP , ARTS-1 , PILS-AP , VEGF-induced aminopeptidase , ER-aminopeptidase 1 , leucyl-specific aminopeptidase PILS

GENE ID SPEZIES
427122 Gallus gallus
488898 Canis lupus familiaris
514617 Bos taurus
100010465 Monodelphis domestica
100173512 Pongo abelii
100391536 Callithrix jacchus
100477111 Ailuropoda melanoleuca
100496768 Xenopus (Silurana) tropicalis
100565356 Anolis carolinensis
100602026 Nomascus leucogenys
393175 Danio rerio
471835 Pan troglodytes
699996 Macaca mulatta
100352256 Oryctolagus cuniculus
51752 Homo sapiens
80898 Mus musculus
80897 Rattus norvegicus
Ausgewählte Anbieter für anti-ERAP1 (ERAP1) Antikörper
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