Ectonucleotide Pyrophosphatase/phosphodiesterase 2 Proteine (ENPP2)

The protein encoded by ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. Zusätzlich bieten wir Ihnen ENPP2 Antikörper (121) und ENPP2 Kits (26) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ENPP2 5168 Q13822
ENPP2 18606 Q9R1E6
ENPP2 84050 Q64610
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Top ENPP2 Proteine auf antikoerper-online.de

Showing 10 out of 14 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$12,127.90
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$12,127.90
Details
Human Cells Cynomolgus His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Human Cells Human His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Human Cells Maus His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
HEK-293 Cells Human His tag   0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
$584.38
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$832.00
Details
HEK-293 Cells Human His tag   10 μg Anmelden zum Anzeigen 2 bis 3 Tage
$180.00
Details
HEK-293 Cells Human His tag Human ENPP-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%. 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
Details
Hefe Yeast His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,256.00
Details

ENPP2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, ,
Mouse (Murine) , ,

Rat (Rattus)

Weitere Proteine zu Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartnern

Human Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartner

  1. We conclude that an ATM-ATX axis interconnects double-strand breaks with silica-induced inflammation and propagates these effects in epithelial cells

  2. we present a new crystal structure of ATX in complex with orthovanadate (ATX-VO5), which binds the Ogamma nucleophile of Thr209 and adopts a trigonal bipyramidal conformation, following the nucleophile attack onto the substrate.We propose that ATX follows the associative two-step in-line displacement mechanism.

  3. The effects of gamma radiation on mRNA levels of autotaxin and 14 inflammatory mediators in adipose tissue and the consequences for radiation therapy and chemotherapy are discussed.

  4. These findings suggest that the promoter hypomethylation and overexpression of ATX might play a contributory role in the pathogenesis of liver fibrosis in biliary atresia.

  5. LPA2 mRNA levels were associated with poorer differentiation, and higher LPA6 levels were associated with microvascular invasion in HCC; both became a risk factor for recurrence after surgical treatment when combined with increased serum ATX levels

  6. AKT (zeige AKT1 Proteine) signaling played a role in ATX secretion regulation to facilitate ATX ER export by enhancing the nuclear factor of activated T cell (zeige NFATC3 Proteine)-mediated p23 (Sec24C (zeige SEC24C Proteine)) expression

  7. Expression of both ATX and IL-6 was increased in systemic scleroderma (SSc) skin, and lysophosphatidic acid-induced IL-6 levels and IL (zeige CYP11A1 Proteine)-6-induced ATX levels were increased i (zeige CYP11A1 Proteine)n fibroblasts from SSc patients compared with (zeige IL6 Proteine) controls.

  8. Elevated levels of autotaxin and soluble markers of immune activation during HCV infection.

  9. These results suggest that the post-transcriptional regulation of ATX expression by HuR (zeige ELAVL1 Proteine) and AUF1 (zeige HNRNPD Proteine) modulates cancer cell migration.

  10. ATX is highly expressed in renal cell carcinoma (zeige MOK Proteine) and bladder carcinoma.

Mouse (Murine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartner

  1. ENPP2 links Activin-A (zeige INHBA Proteine) enhanced mTOR (zeige FRAP1 Proteine) signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva

  2. This study showed that alternative autotaxin-independent pathways are likely responsible for local generation of lysophosphatidic acid in the injured lung.

  3. Hepatocyte autotaxin expression promotes liver fibrosis and liver cancer.

  4. These results indicate that ATX-lysophosphatidic acid-LPA3 (zeige LPAR3 Proteine) signaling at the embryo-epithelial boundary induces decidualization via the canonical HB-EGF (zeige HBEGF Proteine) and COX-2 pathways.

  5. ATX is required for the development and maintenance of dermal fibrosis in a mouse model of bleomycin-induced systemic scleroderma (SSc (zeige CYP11A1 Proteine)) and enables 2 major mediators of SSc (zeige CYP11A1 Proteine) fibrogenesis, lysophosphatidic acid and IL-6 (zeige IL6 Proteine), to amplify the production of each other.

  6. These results suggest that the post-transcriptional regulation of ATX expression by HuR (zeige ELAVL1 Proteine) and AUF1 (zeige HNRNPD Proteine) modulates cancer cell migration.

  7. inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.

  8. findings indicate that the ATX level must be carefully regulated to ensure coordinated vascular formation

  9. Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer

  10. These findings identify ATX and LPA2 (zeige LPAR2 Proteine) as radiation-regulated genes that appear to play a physiological role in DNA repair.

Pig (Porcine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartner

  1. ENPP2 may play an important role in the establishment of pregnancy in pigs by regulating lysophosphatidic acid production at the maternal-conceptus interface.

Cow (Bovine) Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartner

  1. These results indicate that the generation of cyclic phosphatidic acid and lysophosphatidic acid in serum is mainly attributed to autotaxin.

Xenopus laevis Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartner

  1. Defects in forebrain development during loss-of-function experiments for ENPP2, an enzyme involved in the synthesis of extracellular lysophosphatidic acid.

Zebrafish Ectonucleotide Pyrophosphatase/phosphodiesterase 2 (ENPP2) Interaktionspartner

  1. Autotaxin-Lysophosphatidic Acid axis acts downstream of Apoprotein (zeige APOE Proteine) B lipoproteins in endothelial cells.

  2. When autotaxin (Atx), was overexpressed in zebrafish embryos by injecting atx mRNA, the embryos showed cardia bifida, a phenotype induced by down-regulation of sphingosine-1-phosphate signaling.

  3. the ATX-LPA-LPAR axis is a critical regulator of embryonic vascular development that is conserved in vertebrates

  4. This study demonstrate that the zebrafish ortholog to mammalian atx displays evolutionarily conserved expression pattern characteristics.

  5. results suggest a major role for the Atx/Lpar3 (zeige LPAR3 Proteine) signaling axis in regulating KV formation, ciliogenesis and L-R asymmetry via a Wnt (zeige WNT2 Proteine)-dependent pathway

ENPP2 Protein Überblick

Protein Überblick

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.

Genbezeichner und Symbole assoziert mit ENPP2

  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2)
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2)
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 (enpp2)
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 L homeolog (enpp2.L)
  • ectonucleotide pyrophosphatase/phosphodiesterase 2 S homeolog (enpp2.S)
  • atx Protein
  • ATX-X Protein
  • autotaxin Protein
  • enpp2 Protein
  • enpp2a Protein
  • enpp2b Protein
  • LysoPLD Protein
  • MGC132047 Protein
  • NPP2 Protein
  • Npps2 Protein
  • PD-Ialpha Protein
  • Pdnp2 Protein
  • zgc:63550 Protein

Bezeichner auf Proteinebene für ENPP2

E-NPP 2 , autotaxin-t , ectonucleotide pyrophosphatase/phosphodiesterase family member 2 , extracellular lysophospholipase D , phosphodiesterase I/nucleotide pyrophosphatase 2 , plasma lysophospholipase D , autotaxin , lysoPLD , phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin) , ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) , ectonucleotide pyrophosphatase/phosphodiesterase 2 , ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform 2 preproprotein , ectonucleotide pyrophosphatase/phosphodiesterase 2 S homeolog

GENE ID SPEZIES
5168 Homo sapiens
18606 Mus musculus
84050 Rattus norvegicus
420361 Gallus gallus
464353 Pan troglodytes
482026 Canis lupus familiaris
503658 Sus scrofa
532663 Bos taurus
548690 Xenopus (Silurana) tropicalis
705287 Macaca mulatta
735240 Xenopus laevis
100173553 Pongo abelii
100219257 Taeniopygia guttata
100057101 Equus caballus
100332039 Danio rerio
100722506 Cavia porcellus
380218 Xenopus laevis
Ausgewählte Anbieter für ENPP2 Proteine (ENPP2)
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