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May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity). Zusätzlich bieten wir Ihnen EML4 Antikörper (34) und viele weitere Produktgruppen zu diesem Protein an.
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Our findings show that group EML4-ALK variants 3a/b in non-small cell lung cancer may be a major source of ALK inhibitor resistance in the clinic.
EML4-ALK rearrangement detection in malignant pleural effusions is a complementary method for EML4-ALK detection. VETANA and qRT-PCR are more appropriate for MPE detection. EML4-ALK rearrangement in pleural effusions has a predictive value for treatment.
EML4-ALK-positive lung cancer is often highly progressive.
case report in which the EML4-ALK fusion gene was identified as a second primary lung cancer after surgically resecting EGFR (zeige EGFR Proteine) mutation-positive adenocarcinoma
79 (69%) were negative for echinoderm microtubule-associated protein like 4 (EML4)-ALK translocation, nine (8%) were positive and 27 (23%) were unevaluable.
Data suggest that platelets are a valuable source for the non-invasive detection of echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) rearrangements and for predicting and monitoring outcome to crizotinib.
Data show that inhibition of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK)-mediated stem-like properties enhances the anti-tumor effect.
This review describes the biology of EML4 and ALK, explains the main features of EML4-ALK fusion proteins and outline the therapies that target EML4-ALK in cancer. [review]
We further showed that both EML4-ALK and mutant forms of EGFR (zeige EGFR Proteine) modulate PD-L1 (zeige CD274 Proteine) expression via common downstream pathways mediated by MEK (zeige MAP2K1 Proteine)-ERK (zeige EPHB2 Proteine) and by PI3K (zeige PIK3CA Proteine)-AKT (zeige AKT1 Proteine).
EGFR gene mutations and the EML4-ALK fusion gene were detected in 92 lung adenocarcinoma patients in China.
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity).
echinoderm microtubule-associated protein-like 4
, echinoderm microtubule associated protein like 4
, echinoderm microtubule-associated protein-like 4-like
, restrictedly overexpressed proliferation-associated protein
, ropp 120