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Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA (By similarity). Zusätzlich bieten wir Ihnen ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 (Hu Antigen D) Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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The high titres of HuD in SCLC patients and preferable consistency suggested that HuD may serve as a potential diagnostic criterium for SCLC and may serve as a marker of disease progression.
HuD binds to the APP (zeige APP Antikörper) and BACE1 (zeige BACE Antikörper) 3' UTRs and increases APP (zeige APP Antikörper) and BACE1 (zeige BACE Antikörper) levels.
study showed HuD is associated with histological grade, iffuse invasion and nodal metastasis in oral squamous cell carcinoma; it regulates expression of VEGF-A (zeige VEGFA Antikörper), VEGF-D (zeige Figf Antikörper), MMP-2 (zeige MMP2 Antikörper) and MMP-9 (zeige MMP9 Antikörper)
Phosphomimetic mutation at position Ser (zeige SIGLEC1 Antikörper) 221 increased nuclear HUD export.
Alzheimer's disease brain tissues with elevated neuroserpin (zeige SERPINI1 Antikörper) protein also showed increased expression of THRbeta1 and HuD
found that p97 (zeige EIF4G2 Antikörper) and its cofactor, UBXD8 (zeige FAF2 Antikörper), destabilize p21 (zeige CDKN1A Antikörper), MKP-1 (zeige DUSP1 Antikörper), and SIRT1 (zeige SIRT1 Antikörper), three established mRNA targets of the RNA-binding protein (zeige PTBP1 Antikörper) HuR (zeige ELAVL1 Antikörper), by promoting release of HuR (zeige ELAVL1 Antikörper) from mRNA
HuD is a pivotal regulator of insulin translation in pancreatic beta cells.
the endogenous function of ELAVL4 in relation to radiation sensitivity might be the regulation of cell proliferation and death
Complexes of HuD and Tax (zeige CNTN2 Antikörper) epitopes with HLA-A2 are close but imperfect structural mimics: alphabeta T-cell receptor with self antigens is driven to engage HuD in the same traditional binding mode as Tax (zeige CNTN2 Antikörper).
HuD stabilizes the GAP-43 (zeige GAP43 Antikörper) mRNA through a mechanism that is dependent on the length of the poly(A) tail and involves changes in its affinity for the mRNA
Study showed that BDNF (zeige BDNF Antikörper) promotes regeneration induced by spared nerve injury, involving the GAP-43 (zeige GAP43 Antikörper) and NFH (zeige NEFH Antikörper) modulation under the stabilizing activity of HuD.
our results indicate that HuD functions as a novel repressor of lipid synthesis in pancreatic b cells.
Data show that RNA binding protein HuD and special adenine-thymine (AT)-rich DNA-binding protein 1 (SATB1) form a positive regulatory loop that enhances NeuroD1 protein transcription and subsequent neuronal differentiation.
a direct effect of HuD on regulating translation of dendritic Bdnf (zeige BDNF Antikörper) mRNAs
HuD splice variants might play a role in controlling the timing of proliferation/differentiation switching by controlling the translation and alternative splicing of target genes.
Antiretroviral drugs may recruit the HuD-GAP43 (zeige GAP43 Antikörper) pathway, potentially contributing to a response to the antiretroviral neuronal toxicity.
HuD protein is necessary for the establishment of neocortical and hippocampal circuitry and their function.
HuD to be an inducer of ATG5 expression and hence a critical regulator of autophagosome formation in pancreatic beta cells.
HuD promotes BDNF (zeige BDNF Antikörper) expression in brain neurons via selective stabilization of the BDNF (zeige BDNF Antikörper) long 3'UTR (zeige UTS2R Antikörper) mRNA.
HuD controls insulin II translation
Data show that the two elrD transcripts, elrD1 and elrD2, present the same tissue-specific pattern of expression, with distinct developmental regulation.
elrD expression was detected in developing Xenopus retina from stage 26 onwards in the differentiating ganglion cell layer.
Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF and FOS mRNA (By similarity). May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR.
ELAV-like protein 4
, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
, Embryonic lethal, abnormal vision, Drosophila, homolog of, like-4
, Hu antigen D
, hu-antigen D
, paraneoplastic encephalomyelitis antigen HuD
, elav-related D
, embryonic lethal, abnormal vision-related D
, RNA-binding protein HuD
, ELAV-like 4
, HU-antigen D
, RNA-binding protein HUD3
, ELAV (embryonic lethal, abnormal vision)-like 4 (Hu antigen D)
, Protein ElrD
, embryonic lethal, abnormal vision, Drosophila)-like 4