anti-E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) Antikörper

SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Zusätzlich bieten wir Ihnen SIAH1 Proteine (9) und SIAH1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SIAH1 140941 Q920M9
SIAH1 6477 Q8IUQ4
SIAH1    
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Top anti-SIAH1 Antikörper auf antikoerper-online.de

Showing 10 out of 102 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-SIAH1 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Jurkat cell lysate Researcher: Peter Brand & Dr. Oliver Kramer, Institute for Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich-Schiller University JenaApplication: Western blottingSpecies+tissue/cell type: Human embryonic kidney 293T <br />How many ug’s of tissue/cell lysate run on the gel: 1:50 µg human HEK-293T cell lysate Primary Antibody dilution: 1:0000<br />Secondary Antibody: Anti-rabbit-IgG <br />Secondary Antibody Dilution: 1:0000 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from A549/HeLa cells, using SIAH1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Ziege Unkonjugiert ELISA, WB ABIN184675 staining (0.1µg/ml) of Human Liver lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$326.89
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of SIAH1 Antibody (Center) in human placenta tissue lysates (35ug/lane).This demonstrates the SIAH1 antibody detected the SIAH1 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Rind (Kuh) Ziege Unkonjugiert EIA, IP, WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$375.38
Details
Human Ziege Unkonjugiert IP, ELISA, WB Western Blot: SIAH1 Antibody [ABIN268796] - Analysis of Human Liver lysate (RIPA buffer, 35ug total protein per lane). Western Blot: SIAH1 Antibody [ABIN268796] - Analysis of Mouse (A, C) and Rat (B, D) Brain (A, B) and Liver (C, D) lysates (35ug protein in RIPA buffer). 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$408.19
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: SIAH1 Antibody [NBP2-20356] - Analysis of paraffin-embedded Lung Papillary Adenocarcinoma, using antibody at 1:250 dilution. Western Blot: SIAH1 Antibody [NBP2-20356] - A: U87-MG. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Fledermaus Kaninchen Unkonjugiert IHC (p), WB Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$595.83
Details
Fledermaus Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
Details

SIAH1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-SIAH1 Antikörper

  1. Human Polyclonal SIAH1 Primary Antibody für IP, ELISA - ABIN268796 : Guigon, Zhao, Lu, Willingham, Cheng: Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor. in Molecular and cellular biology 2008 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal SIAH1 Primary Antibody für ELISA, WB - ABIN184675 : Susini, Passer, Amzallag-Elbaz, Juven-Gershon, Prieur, Privat, Tuynder, Gendron, Israël, Amson, Oren, Telerman: Siah-1 binds and regulates the function of Numb. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 2 Pubmed References

  3. Monoclonal SIAH1 Primary Antibody für IP, WB - ABIN534024 : Schmidt, Park, Ahmed, Gundelach, Reed, Cheng, Knudsen, Tang: Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue. in Cancer research 2007 (PubMed)

  4. Human Polyclonal SIAH1 Primary Antibody für IHC, IHC (p) - ABIN4353439 : Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. in Oncotarget 2015 (PubMed)

Weitere Antikörper gegen SIAH1 Interaktionspartner

Human E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) Interaktionspartner

  1. The crystallographic models provide structural insights into the substrate binding of the SIAH family E3 ubiquitin ligases that are critically involved in regulating cancer-related pathways.

  2. Results showed that SIAH1 and PTP4A1 (zeige PTP4A1 Antikörper) expression was regulated by mir (zeige MLXIP Antikörper)-944 in breast cancer cells. miR (zeige MLXIP Antikörper)-944 binds directly the 3 UTR (zeige UTS2R Antikörper) of their promotor region.

  3. Study identified SIAH1/2 (SIAH) as the E3 ligase mediating Wnt (zeige WNT2 Antikörper)-induced Axin (zeige AXIN1 Antikörper) degradation. SIAH proteins promote the ubiquitination and proteasomal degradation of Axin (zeige AXIN1 Antikörper) through interacting with a VxP motif in the GSK3 (zeige GSK3b Antikörper)-binding domain of Axin (zeige AXIN1 Antikörper), and this function of SIAH is counteracted by GSK3 (zeige GSK3b Antikörper) binding to Axin (zeige AXIN1 Antikörper).

  4. results suggest that CacyBP/SIP (zeige CACYBP Antikörper) is involved in regulation of the Hsp90 chaperone (zeige HSP90 Antikörper) machinery

  5. PINK1 (zeige PINK1 Antikörper) disease mutants failed to recruit synphilin-1 (zeige SNCAIP Antikörper) and did not activate mitophagy, indicating that PINK1 (zeige PINK1 Antikörper)-synphilin-1 (zeige SNCAIP Antikörper)-SIAH-1 represents a new parkin (zeige PARK2 Antikörper)-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease.

  6. Results suggest that activated STAT3 (zeige STAT3 Antikörper) regulates active beta-catenin (zeige CTNNB1 Antikörper) protein levels via stabilization of SIAH-1 and the subsequent ubiquitin-dependent proteasomal degradation of beta-catenin (zeige CTNNB1 Antikörper) in HEK293T cells.

  7. Siah-1 expression was observed in 41.4% of oral squamous cell carcinoma. Siah-1 was expressed in the cytoplasm and cell membranes, and partially in the nucleus .

  8. SIAH1 is associated with a tumor promoting role in breast cancer.

  9. In neuroblastoma cells, siRNA silencing of SIAH1 promoted cellular proliferation and suppressed apoptosis. Protein and mRNA expression of alpha-synuclein, LC3-II and p53 decreased after SIAH1 knockdown. E1 protein and mRNA levels increased after SIAH1 siRNA.

  10. Results demonstrated that miR-107 directly down-regulated SIAH1 expression in human breast cancer cells. An inverse correlation between the expression of miR-107 and SIAH1 was found in human breast cancer tissues and cell lines.

Xenopus laevis E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) Interaktionspartner

  1. two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1) were characterized.

SIAH1 Antigen-Profil

Protein Überblick

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Genbezeichner und Symbole assoziert mit SIAH1

  • E3 ubiquitin-protein ligase Siah1 (Tsp_03055) Antikörper
  • E3 ubiquitin-protein ligase siah-1 (siah-1) Antikörper
  • siah E3 ubiquitin protein ligase 1 (Siah1) Antikörper
  • siah E3 ubiquitin protein ligase 1 (siah1) Antikörper
  • siah E3 ubiquitin protein ligase 1 (SIAH1) Antikörper
  • siah E3 ubiquitin protein ligase 1 L homeolog (siah1.L) Antikörper
  • id:ibd2635 Antikörper
  • siah Antikörper
  • Siah1 Antikörper
  • SIAH1A Antikörper
  • zgc:56026 Antikörper

Bezeichner auf Proteinebene für SIAH1

E3 ubiquitin-protein ligase Siah1 , E3 ubiquitin-protein ligase SIAH1 , seven in absentia homolog 1 , siah-1 , siah-1a , seven in absentia 1A , seven in absentia-like protein 1

GENE ID SPEZIES
10900332 Trichinella spiralis
177138 Caenorhabditis elegans
140941 Rattus norvegicus
80955 Danio rerio
534655 Bos taurus
374076 Gallus gallus
6477 Homo sapiens
443864 Xenopus laevis
487293 Canis lupus familiaris
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