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SIAH1 encodes a protein that is a member of the seven in absentia homolog (SIAH) family. Zusätzlich bieten wir Ihnen SIAH1 Proteine (9) und SIAH1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SIAH1 Primary Antibody für IP, ELISA - ABIN268796
Guigon, Zhao, Lu, Willingham, Cheng: Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor. in Molecular and cellular biology 2008
Show all 6 Pubmed References
Human Polyclonal SIAH1 Primary Antibody für ELISA, WB - ABIN184675
Susini, Passer, Amzallag-Elbaz, Juven-Gershon, Prieur, Privat, Tuynder, Gendron, Israël, Amson, Oren, Telerman: Siah-1 binds and regulates the function of Numb. in Proceedings of the National Academy of Sciences of the United States of America 2001
Show all 2 Pubmed References
Monoclonal SIAH1 Primary Antibody für IP, WB - ABIN534024
Schmidt, Park, Ahmed, Gundelach, Reed, Cheng, Knudsen, Tang: Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue. in Cancer research 2007
Human Polyclonal SIAH1 Primary Antibody für IHC, IHC (p) - ABIN4353439
Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. in Oncotarget 2015
The crystallographic models provide structural insights into the substrate binding of the SIAH family E3 ubiquitin ligases that are critically involved in regulating cancer-related pathways.
Results showed that SIAH1 and PTP4A1 (zeige PTP4A1 Antikörper) expression was regulated by mir (zeige MLXIP Antikörper)-944 in breast cancer cells. miR (zeige MLXIP Antikörper)-944 binds directly the 3 UTR (zeige UTS2R Antikörper) of their promotor region.
Study identified SIAH1/2 (SIAH) as the E3 ligase mediating Wnt (zeige WNT2 Antikörper)-induced Axin (zeige AXIN1 Antikörper) degradation. SIAH proteins promote the ubiquitination and proteasomal degradation of Axin (zeige AXIN1 Antikörper) through interacting with a VxP motif in the GSK3 (zeige GSK3b Antikörper)-binding domain of Axin (zeige AXIN1 Antikörper), and this function of SIAH is counteracted by GSK3 (zeige GSK3b Antikörper) binding to Axin (zeige AXIN1 Antikörper).
results suggest that CacyBP/SIP (zeige CACYBP Antikörper) is involved in regulation of the Hsp90 chaperone (zeige HSP90 Antikörper) machinery
PINK1 (zeige PINK1 Antikörper) disease mutants failed to recruit synphilin-1 (zeige SNCAIP Antikörper) and did not activate mitophagy, indicating that PINK1 (zeige PINK1 Antikörper)-synphilin-1 (zeige SNCAIP Antikörper)-SIAH-1 represents a new parkin (zeige PARK2 Antikörper)-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease.
Results suggest that activated STAT3 (zeige STAT3 Antikörper) regulates active beta-catenin (zeige CTNNB1 Antikörper) protein levels via stabilization of SIAH-1 and the subsequent ubiquitin-dependent proteasomal degradation of beta-catenin (zeige CTNNB1 Antikörper) in HEK293T cells.
Siah-1 expression was observed in 41.4% of oral squamous cell carcinoma. Siah-1 was expressed in the cytoplasm and cell membranes, and partially in the nucleus .
SIAH1 is associated with a tumor promoting role in breast cancer.
In neuroblastoma cells, siRNA silencing of SIAH1 promoted cellular proliferation and suppressed apoptosis. Protein and mRNA expression of alpha-synuclein, LC3-II and p53 decreased after SIAH1 knockdown. E1 protein and mRNA levels increased after SIAH1 siRNA.
Results demonstrated that miR-107 directly down-regulated SIAH1 expression in human breast cancer cells. An inverse correlation between the expression of miR-107 and SIAH1 was found in human breast cancer tissues and cell lines.
two splicing forms, Siah1a and Siah1b, of the Xenopus seven in absentia homolog 1 gene (Siah1) were characterized.
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
E3 ubiquitin-protein ligase Siah1
, E3 ubiquitin-protein ligase SIAH1
, seven in absentia homolog 1
, seven in absentia 1A
, seven in absentia-like protein 1