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The protein encoded by DARC is a glycosylated membrane protein and a non-specific receptor for several chemokines. Zusätzlich bieten wir Ihnen DARC Antikörper (142) und DARC Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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The data suggest that selective exposure of the Duffy binding protein (DBP (zeige GC ELISA Kits)) binding site within DARC is key to the preferential binding of DBP (zeige GC ELISA Kits) to immature reticulocytes, which is the potential mechanism underlying the preferential infection of a reticulocyte subset by P vivax.
population genetic analysis of DARC shows its association with malaria resistance
We showed that DARC expression is down-regulated in CRC (zeige CALR ELISA Kits) and associated with clinical pathological features and MVD (zeige MVD ELISA Kits) of CRC (zeige CALR ELISA Kits). DARC might be involved in tumorigenesis, progression, angiogenesis, and metastasis of CRC (zeige CALR ELISA Kits).
DARC is required for Staphylococcus aureus-mediated lysis of human erythrocytes, and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis.
study demonstrates the association of SNP rs12075 from DARC gene with the levels of serum IL8 (zeige IL8 ELISA Kits)
DARC levels are elevated in human keloid fibroblasts and might inhibit the secretion of CCL2 (zeige CCL2 ELISA Kits).
Through molecular genotyping we also identified polymorphisms in RhCE (zeige RHCE ELISA Kits), Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.
Duffy blood group
Isothermal titration calorimetry studies show these structures are part of a multi-step binding pathway, and individual point mutations of residues contacting DARC result in a complete loss of RBC (zeige CACNA1C ELISA Kits) binding by DBP (zeige GC ELISA Kits)-RII.
DARC polymorphisms may influence the naturally acquired inhibitory anti-Duffy binding protein II (zeige ANXA4 ELISA Kits) immunity
The DARC/CD234 is expressed on macrophages and stabilizes CD82 (zeige CD82 ELISA Kits) on long-term repopulating hematopoietic stem cells, promoting their quiescence.
Ackr1 deficiency appears to be protective in the ApoE (zeige APOE ELISA Kits) knockout model of atherogenesis, but it is associated with only modest changes in cytokine and chemokine (zeige CCL1 ELISA Kits) expression as well as T-cell subset frequency and inflammatory macrophage content.
Darc plays a role in modulating the regulation of inflammatory response to bone injury and that lack of Darc expression promotes cartilage formation in fracture calluses but does not affect bony union or fracture healing at 21 days post-fracture.
The data showed a role for erythrocyte DARC as a chemokine (zeige CCL1 ELISA Kits) reservoir and that endothelial DARC contributes to the pathogenesis of experimental autoimmune encephalomyelitis by shuttling chemokines across the blood-brain barrier.
DARC is crucial for chemokine (zeige CCL1 ELISA Kits)-mediated leukocyte recruitment in vivo.
Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion.
Vascular endothelial cells may induce Duffy protein to regulate leukocytes and/or chemokine (zeige CCL1 ELISA Kits) trafficking
role of the Duffy antigen and glycophorin A (zeige GYPA ELISA Kits) as receptors for rodent malaria parasite invasion of erythrocytes
DARC functions to clear angiogenic CXC chemokines from the prostate tumor microcirculation
Darc regulates bone mineral density (BMD (zeige BEST1 ELISA Kits))negatively by increasing osteoclast formation. Darc is proposed as a candidate gene for chromosome 1 BMD (zeige BEST1 ELISA Kits) QTL2.
the 5' flanking region of the DARC gene was isolated and characterized
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene.
Duffy blood group, chemokine receptor
, duffy antigen/chemokine receptor
, Duffy antigen/chemokine receptor
, Duffy blood group antigen
, Fy glycoprotein
, atypical chemokine receptor 1
, glycoprotein D
, plasmodium vivax receptor
, Duffy antigen receptor for chemokines
, blood group antigen
, duffy antigen/receptor for chemokine glycoprotein