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DYRK1B is a member of the DYRK family of protein kinases. Zusätzlich bieten wir Ihnen DYRK1B Antikörper (108) und DYRK1B Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
Dyrk1B was overexpressed in breast cancer tissues and cells and correlates with FoxO1 (zeige FOXO1 ELISA Kits) phosphorylation and cell proliferation.
High DYRK1B expression is associated with pancreatic and skin cancers.
The study shows that DYRK1B is a novel ERK2 (zeige MAPK1 ELISA Kits) substrate, uncovering new links between two kinases involved in cell fate decisions.
Data reveal a novel role for miR (zeige MLXIP ELISA Kits)-9 in regulation of the NFAT (zeige NFATC1 ELISA Kits) pathway by targeting KPNB1 (zeige KPNB1 ELISA Kits) and DYRK1B.
NKX3.1 (zeige NKX3-1 ELISA Kits) and DYRK1B were shown to interact via the DYRK1B kinase domain. In vitro kinase assay showed that DYRK1B phosphorylated NKX3.1 (zeige NKX3-1 ELISA Kits) at serine 185, a residue critical for NKX3.1 (zeige NKX3-1 ELISA Kits) steady-state turnover.
Upregulation of Mirk mRNA expression is mediated by CREB (zeige CREB1 ELISA Kits) binding to two sites in the Mirk promoter upstream of the transcription start site and one site within exon 4.
A founder mutation was identified in DYRK1B, substituting cysteine for arginine at position 102 in 3 families with metabolic syndrome.
DYRK1B is a novel Thr (zeige TRH ELISA Kits)(286)-CCND1 (zeige CCND1 ELISA Kits) kinase that acts independently of GSK3beta (zeige GSK3b ELISA Kits) to promote CCND1 (zeige CCND1 ELISA Kits) degradation.
Mirk/Dyrk1B plays an important role in ovarian cancer cell survival through modulating FoxO (zeige FOXO3 ELISA Kits) translocation.
In line with a redirection of autocrine toward paracrine HH signaling by a KRAS-DYRK1B network, we find high levels of GLI1 (zeige GLI1 ELISA Kits) expression restricted to the stromal compartment and not to SHH (zeige SHH ELISA Kits)-expressing tumor cells in pancreatic adenocarcinoma.
results suggest that functional interactions between BM88/Cend1 (zeige CEND1 ELISA Kits), RanBPM (zeige RANBP9 ELISA Kits) and Dyrk1B affect the balance between cellular proliferation and differentiation in Neuro 2a cells
Cirp (zeige CIRBP ELISA Kits) functions to fine-tune the proliferation of undifferentiated spermatogonia by interacting with Dyrk1b.
p38 MAP Kinase (zeige MAPK14 ELISA Kits) suppresses the function of Mirk as a transcriptional activator only when cells are proliferating
dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation
p27Kip1 (zeige CDKN1B ELISA Kits) is stabilized in G(0) by Mirk/dyrk1B kinase
Mirk may function together with GSK3beta (zeige GSK3b ELISA Kits) to assist cell arrest by destabilizing cyclin D1 (zeige CCND1 ELISA Kits).
Mirk is induced within the initial 24 h of myogenic differentiation and enables MEF2 (zeige MEF2C ELISA Kits) to transcribe the myogenin (zeige MYOG ELISA Kits) gene by decreasing the nuclear accumulation of class II HDACs
Mirk is anti-apoptotic in myoblasts
BCL2 (zeige BCL2 ELISA Kits) and BCL-xL (zeige BCL2L1 ELISA Kits) facilitation of G0 quiescence requires BAX (zeige BAX ELISA Kits), BAK (zeige BAK1 ELISA Kits), and p27 (zeige CDKN1B ELISA Kits) phosphorylation by Mirk
DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain.
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
, dual specificity tyrosine-phosphorylation-regulated kinase 1B-like
, dual specificity tyrosine-phosphorylation-regulated kinase 1B
, minibrain-related kinase
, mirk protein kinase
, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A