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DYRK1B is a member of the DYRK family of protein kinases. Zusätzlich bieten wir Ihnen DYRK1B Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal DYRK1B Primary Antibody für IHC (p), WB - ABIN391774
Takahashi-Yanaga, Mori, Matsuzaki, Watanabe, Hirata, Miwa, Morimoto, Sasaguri: Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells. in The Journal of biological chemistry 2006
Show all 4 Pubmed References
Dyrk1B was overexpressed in breast cancer tissues and cells and correlates with FoxO1 (zeige FOXO1 Antikörper) phosphorylation and cell proliferation.
High DYRK1B expression is associated with pancreatic and skin cancers.
The study shows that DYRK1B is a novel ERK2 (zeige MAPK1 Antikörper) substrate, uncovering new links between two kinases involved in cell fate decisions.
Data reveal a novel role for miR (zeige MLXIP Antikörper)-9 in regulation of the NFAT (zeige NFATC1 Antikörper) pathway by targeting KPNB1 (zeige KPNB1 Antikörper) and DYRK1B.
NKX3.1 (zeige NKX3-1 Antikörper) and DYRK1B were shown to interact via the DYRK1B kinase domain. In vitro kinase assay showed that DYRK1B phosphorylated NKX3.1 (zeige NKX3-1 Antikörper) at serine 185, a residue critical for NKX3.1 (zeige NKX3-1 Antikörper) steady-state turnover.
Upregulation of Mirk mRNA expression is mediated by CREB (zeige CREB1 Antikörper) binding to two sites in the Mirk promoter upstream of the transcription start site and one site within exon 4.
A founder mutation was identified in DYRK1B, substituting cysteine for arginine at position 102 in 3 families with metabolic syndrome.
DYRK1B is a novel Thr (zeige TRH Antikörper)(286)-CCND1 (zeige CCND1 Antikörper) kinase that acts independently of GSK3beta (zeige GSK3b Antikörper) to promote CCND1 (zeige CCND1 Antikörper) degradation.
Mirk/Dyrk1B plays an important role in ovarian cancer cell survival through modulating FoxO (zeige FOXO3 Antikörper) translocation.
In line with a redirection of autocrine toward paracrine HH signaling by a KRAS-DYRK1B network, we find high levels of GLI1 (zeige GLI1 Antikörper) expression restricted to the stromal compartment and not to SHH (zeige SHH Antikörper)-expressing tumor cells in pancreatic adenocarcinoma.
results suggest that functional interactions between BM88/Cend1 (zeige CEND1 Antikörper), RanBPM and Dyrk1B affect the balance between cellular proliferation and differentiation in Neuro 2a cells
Cirp (zeige CIRBP Antikörper) functions to fine-tune the proliferation of undifferentiated spermatogonia by interacting with Dyrk1b.
p38 MAP Kinase (zeige MAPK14 Antikörper) suppresses the function of Mirk as a transcriptional activator only when cells are proliferating
dyrk1B is a Rho-induced kinase active in skeletal muscle differentiation
p27Kip1 (zeige CDKN1B Antikörper) is stabilized in G(0) by Mirk/dyrk1B kinase
Mirk may function together with GSK3beta (zeige GSK3b Antikörper) to assist cell arrest by destabilizing cyclin D1 (zeige CCND1 Antikörper).
Mirk is induced within the initial 24 h of myogenic differentiation and enables MEF2 (zeige MEF2C Antikörper) to transcribe the myogenin (zeige MYOG Antikörper) gene by decreasing the nuclear accumulation of class II HDACs
Mirk is anti-apoptotic in myoblasts
BCL2 (zeige BCL2 Antikörper) and BCL-xL (zeige BCL2L1 Antikörper) facilitation of G0 quiescence requires BAX (zeige BAX Antikörper), BAK (zeige BAK1 Antikörper), and p27 (zeige CDKN1B Antikörper) phosphorylation by Mirk
DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain.
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
, dual specificity tyrosine-phosphorylation-regulated kinase 1B-like
, dual specificity tyrosine-phosphorylation-regulated kinase 1B
, minibrain-related kinase
, mirk protein kinase
, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A