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The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Zusätzlich bieten wir Ihnen DUSP1 Antikörper (112) und DUSP1 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human DUSP1 ELISA Kit - ABIN1130767
Khadir, Tiss, Abubaker, Abufarha, Al-Khairi, Cherian, John, Kavalakatt, Warsame, Al-Madhoun, Al-Ghimlas, Elkum, Behbehani, Dermime, Dehbi: MAP kinase phosphatase DUSP1 is overexpressed in human obese and modulated by physical activity. in American journal of physiology. Endocrinology and metabolism 2014
this work indicates that suppression of JNK1 (zeige MAPK8 ELISA Kits)/2 activity by MKP-1 maintains PARP-1 (zeige PARP1 ELISA Kits) levels and suggests that MKP-1-mediated cisplatin resistance can be bypassed by PARP-1 (zeige PARP1 ELISA Kits) inhibition.
Mean morning and evening DUSP1 mRNA levels showed significant increase during Ramadan compared to Shabaan, however, its diurnal rhythm was maintained. Morning IL-1alpha mRNA expression remained significantly higher than in the evening during Ramadan, but was markedly decreased compared to Shabaan.
Methylation-mediated silencing of the DUSP-1 promoter does not appear to be associated with reduced expression, indicating the involvement of other factors in specific suppression of DUSP-1 in diabetes-associated cardiac hypertrophy.
Increased MAP2K6 (zeige MAP2K6 ELISA Kits), MAP4K3 (zeige MAP4K3 ELISA Kits), and DUSP1 gene expressions in post-chemotherapy samples indicate a poor clinical outcome in osteosarcoma patients.
The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A (zeige PPP2R4 ELISA Kits), CDC25 (zeige RASGRF1 ELISA Kits) and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
Dual-specific phosphatase (DUSP1) was found to inhibit gallbladder cancer (GBC) cell proliferation, migration and invasion.
The results presented here emphasize the importance of MKP-1 as a mediator of therapeutic effects of glucocorticoids in inflammatory lung diseases as well as its potential as a novel anti-inflammatory drug target.
we show that IL-1 (zeige IL1A ELISA Kits) induces robust p38a (zeige MAPK14 ELISA Kits) activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a (zeige MAPK14 ELISA Kits) activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 through a negative feedback to pp38, its basal activity is controlled by both TAB1 (zeige TAB1 ELISA Kits) and MKP1 through a positive feedback loop.
Our results emphasize the importance of MKP-1 as a potential predictive biomarker for a subset of breast cancer patients with worse outcome and less susceptibility to treatment.
Collectively, these data indicated that DUSP1 may induce the resistance against paclitaxel through the p38 MAPK (zeige MAPK14 ELISA Kits)-mediated overexpression of p-glycoprotein in human ovarian cancer cells.
MKP-1 regulates IL-1beta (zeige IL1B ELISA Kits) production through stabilization of HIF-1alpha (zeige HIF1A ELISA Kits). The induction of HIF-1alpha (zeige HIF1A ELISA Kits) protein in MKP-1 deficiency is partly due to p38MAPK (zeige MAPK14 ELISA Kits) activation in response to LPS (zeige TLR4 ELISA Kits).
this work identifies a previously unrecognized role for DUSP1 in regulating autophagy.
c-FOS and DUSP1 expression levels determine the threshold of tyrosine kinase (zeige TYRO3 ELISA Kits) inhibitor (TKI) efficacy, such that growth-factor-induced expression of c-FOS and DUSP1 confers intrinsic resistance to TKI therapy in a wide-ranging set of leukemias.
PTHrP (zeige PTHLH ELISA Kits) counteracts the pro-apoptotic actions of reactive oxygen species by a mechanism dependent on MKP1-induced dephosphorylation.
A2AR (zeige ADORA2A ELISA Kits) signaling regulates both basal and LPS (zeige TLR4 ELISA Kits)-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway.
these data suggest an important role for DUSPs in regulating MAPK (zeige MAPK1 ELISA Kits) dephosphorylation, with an emphasis on DUSP1, during early adipogenesis
Loss of DUSP1 does not cause changes in cartilage degeneration and gait in a mouse model of spontaneous osteoarthritis at 21 months of age.
Nr4a1 (zeige NR4A1 ELISA Kits) induction is dependent on ERK1/2 (zeige MAPK1/3 ELISA Kits) and that MKP-1 negatively regulates this induction.
MKP-1 negatively regulates chemokine (zeige CCL1 ELISA Kits)-driven osteoclast formation and subsequent bone resorption in response to LPS (zeige TLR4 ELISA Kits) stimulation
results suggest that the p38alpha (zeige MAPK14 ELISA Kits)-MKP-1 signaling axis links IL-17R signaling in tissue-resident cells to autoimmune inflammation dependent on infiltrating T(H)17 cells.
MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2 (zeige MAPK1/3 ELISA Kits)-mediated aldosterone production in response to the hormone.
Agonist stimulation of vascular smooth muscle increases PKC (zeige FYN ELISA Kits) activity, which, in turn, increases MKP-1 activity and maintains MAPK1 (zeige MAPK1 ELISA Kits) activity at submaximal values.
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
dual specificity protein phosphatase 1
, dual specificity phosphatase 1
, MAP kinase phosphatase 1
, dual specificity protein phosphatase hVH1
, mitogen-activated protein kinase phosphatase 1
, protein-tyrosine phosphatase CL100
, serine/threonine specific protein phosphatase
, mitogen-activated protein kinase phosphatase-1
, protein tyrosine phosphatase, non-receptor type 16
, protein-tyrosine phosphatase 3CH134
, protein-tyrosine phosphatase ERP
, 3CH134/CL100 PTPase
, MAP kinase phosphatase-1
, mitogen-activated protein (MAP) kinase phosphatase-1
, oxidative stress-inducible protein tyrosine phosphatase
, protein tyrosine phosphatase non-receptor type 16
, protein-tyrosine phosphatase non-receptor type 16
, MAPK phosphatase 1