Dual Oxidase 1 Proteine (DUOX1)

The protein encoded by DUOX1 is a glycoprotein and a member of the NADPH oxidase family. Zusätzlich bieten wir Ihnen DUOX1 Antikörper (35) und DUOX1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
DUOX1 53905 Q9NRD9
Maus DUOX1 DUOX1 99439  
Ratte DUOX1 DUOX1 266807 Q8CIY2
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Showing 3 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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DUOX1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,

Weitere Proteine zu Dual Oxidase 1 (DUOX1) Interaktionspartnern

Purple Sea Urchin (Strongylocentrotus purpuratus) Dual Oxidase 1 (DUOX1) Interaktionspartner

  1. dual oxidase Udx1 has a role in the oxidative burst at fertilization

Zebrafish Dual Oxidase 1 (DUOX1) Interaktionspartner

  1. The duox expression in zebrafish during early nervous system development from 12 to 48 hours post fertilization.

  2. The results reveal a crucial role for TNFalpha (zeige TNF Proteine)/TNFR2 (zeige TNFRSF1B Proteine) axis in the protection of the skin against DUOX1-mediated oxidative stress.

  3. extracellular ATP acting as an early danger signal is responsible for the activation of Duox1 via a P2YR/PLC (zeige PLC Proteine)/Ca(2 (zeige CA2 Proteine)+) signaling pathway and the production of H2O2

  4. Zebrafish duox is highly expressed in intestinal epithelial cells. Knockdown of Duox impaired larval capacity to control enteric Salmonella infection.

Human Dual Oxidase 1 (DUOX1) Interaktionspartner

  1. Our findings implicate epithelial DUOX1 as a pivotal mediator of IL-33 (zeige IL33 Proteine)-dependent activation of innate airway type 2 immune responses to common airborne allergens and indicate that enhanced DUOX1 expression and IL-33 (zeige IL33 Proteine) secretion might present important contributing features of allergic asthma.

  2. Cox (zeige COX8A Proteine) multivariate regression analysis demonstrated that DUOX1, GLS2 (zeige GLS2 Proteine), FBP1 (zeige FBP1 Proteine) and age were independent risk factors for the prognosis of HCC (zeige FAM126A Proteine) patients after surgery

  3. DUOX1 expression in liver tumors is a potential prognostic tool for patients.

  4. Nox4 (zeige NOX4 Proteine) and Duox1/Duox2 mediate redox activation of mesenchymal cell migration by PDGF (zeige PDGFA Proteine).

  5. These data reveal a key role of DUOX1-dependent hydrogen peroxide production in long-term persistent radio-induced DNA damage.

  6. Studies demonstrate the importance of DUOX1 in epithelial redox signaling through reversible S-glutathionylation of a range of proteins, including proteins involved in cytoskeletal regulation and MAPK (zeige MAPK1 Proteine) signaling pathways involved in cell migration.

  7. Duox2 (zeige DUOX2 Proteine) proteins possessing the A-loops of Nox1 (zeige NOX1 Proteine) or Nox5 (zeige NOX5 Proteine) co-expressed with DuoxA2 (zeige DUOXA2 Proteine) showed enhanced O2 () release, and Duox1 proteins possessing the A-loops of Nox1 (zeige NOX1 Proteine) or Nox5 (zeige NOX5 Proteine) co-expressed with DuoxA1 (zeige DUOXA1 Proteine) acquired O2 () leakage

  8. DUOX1 is the major H2O2-producing source in NHKs stimulated with Ca(2 (zeige CA2 Proteine)+), and plays a significant role in regulating the expression of specific markers necessary for the normal differentiation of keratinocytes

  9. Further, ROS (zeige ROS1 Proteine) generated by Duox enzymes localized adjacent to nuclear speckles altered the splicing of viral genes

  10. Despite the high sequence similarity shared between DUOX1 and DUOX2 (zeige DUOX2 Proteine), the two isoforms present distinct regulations, tissue expression and catalytic functions

Mouse (Murine) Dual Oxidase 1 (DUOX1) Interaktionspartner

  1. Redox-dependent regulation of EGFR (zeige EGFR Proteine) activation in airway epithelial cells was found to strongly depend on activation of either DUOX1 or NOX2 (zeige CYBB Proteine).

  2. Our findings implicate epithelial DUOX1 as a pivotal mediator of IL-33 (zeige IL33 Proteine)-dependent activation of innate airway type 2 immune responses to common airborne allergens and indicate that enhanced DUOX1 expression and IL-33 (zeige IL33 Proteine) secretion might present important contributing features of allergic asthma.

  3. findings suggest that LPS (zeige TLR4 Proteine)-TLR-4 (zeige TLR4 Proteine)-induced KC or MIP-2 (zeige CXCL2 Proteine) cytokine induction and subsequent neutrophil recruitment in the airway does not require DUOX-derived hydrogen peroxide from airway epithelium

  4. These findings suggest that DUOX-derived H2O2 has an important role in signaling neutrophils into allergic airways

  5. Studies demonstrate the importance of DUOX1 in epithelial redox signaling through reversible S-glutathionylation of a range of proteins, including proteins involved in cytoskeletal regulation and MAPK (zeige MAPK1 Proteine) signaling pathways involved in cell migration.

  6. PA-LPS (zeige TLR4 Proteine)-induced MUC5AC and Clca3 expression is partly through Duox1

  7. In vivo DUOX1 silencing significantly suppressed naphthalene-induced activation of STAT3 (zeige STAT3 Proteine).

  8. Urothelial cells produce hydrogen peroxide through the activation of Dual oxidase 1

  9. Duox1 is the main source of H(2)O(2) in the rat thyroid cell line PCCl3.

DUOX1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Genbezeichner und Symbole assoziert mit Dual Oxidase 1 Proteine (DUOX1)

  • dual oxidase 1 (duox1)
  • dual oxidase 1 (DUOX1)
  • dual oxidase (duox)
  • dual oxidase 1 (AaeL_AAEL007563)
  • dual oxidase 1 (Duox1)
  • 9930101G15Rik Protein
  • AW987690 Protein
  • duox1 Protein
  • Duox2 Protein
  • LNOX1 Protein
  • LNOX2 Protein
  • NOXEF1 Protein
  • NOXEF2 Protein
  • P138-TOX Protein
  • THOX1 Protein
  • THOX2 Protein
  • Udx1 Protein

Bezeichner auf Proteinebene für Dual Oxidase 1 Proteine (DUOX1)

dual oxidase 1 , NADPH thyroid oxidase 1 , flavoprotein NADPH oxidase , large NOX 1 , long NOX 1 , nicotinamide adenine dinucleotide phosphate oxidase , thyroid oxidase 1 , dual oxidase 2

GENE ID SPEZIES
588656 Strongylocentrotus purpuratus
100012836 Monodelphis domestica
467673 Pan troglodytes
565097 Danio rerio
5569378 Aedes aegypti
53905 Homo sapiens
99439 Mus musculus
266807 Rattus norvegicus
403720 Canis lupus familiaris
397177 Sus scrofa
510409 Bos taurus
Ausgewählte Anbieter für DUOX1 Proteine (DUOX1)
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