anti-Doublecortin-Like Kinase 1 (DCLK1) Antikörper

DCLK1 encodes a member of the protein kinase superfamily and the doublecortin family. Zusätzlich bieten wir Ihnen DCLK1 Kits (24) und DCLK1 Proteine (17) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
DCLK1 9201 O15075
DCLK1 13175 Q9JLM8
DCLK1 83825 O08875
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-DCLK1 Antikörper auf antikoerper-online.de

Showing 10 out of 116 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of DCAMKL1 Antibody (N-term) in mouse brain tissue lysate. DCAMKL1 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DCAMKL1 Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. The DCAMKL1 Antibody (C-term ) is used in Western blot to detect DCAMKL1 in mouse heart tissue lysate. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IF, IHC (p), WB The DCAMKL1 Antibody (C-term )(ABIN391324) western blot analysis in mouse heart tissuelysates (35 µg/lane).This demonstrates the DCAMKL1 antibody detected the DCAMKL1 protein (arrow). Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DCAMKL1 Antibody (C-term) (ABIN391324), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of DCAMKL1 Antibody (N-term) (ABIN391323) in mouse brain tissue lysate. DCAMKL1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. DCAMKL1 Antibody (D13) (ABIN391323) western blot analysis in T47D cell line lysates (35 µg/lane).This demonstrates the DCAMKL1 antibody detected the DCAMKL1 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert IF, WB Immunofluorescence of monoclonal antibody to DCAMKL1 on NIH/3T3 cell (antibody concentration 10 µg/mL). DCAMKL1 monoclonal antibody (M03), clone 6H4 Western Blot analysis of DCAMKL1 expression in NIH/3T3. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$375.38
Details
Maus Kaninchen Unkonjugiert WB Mouse Dclk1 Antibody (N-term)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Dclk1 antibody detected the Dclk1 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert WB DCLK1 Antibody (C-term) (ABIN1881252) western blot analysis in MDA-MB231 cell line lysates (35 µg/lane). This demonstrates the DCLK1 antibody detected the DCLK1 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$537.17
Details

DCLK1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , , ,
, ,
,
, , , , , , , , , , , , , , , ,
Mouse (Murine) , ,


, , , , , , , , , , , , , , , ,
Rat (Rattus) , ,


, , , , , , , , , , , , ,

Am meisten referenzierte anti-DCLK1 Antikörper

  1. Human Polyclonal DCLK1 Primary Antibody für IF, IHC (p) - ABIN391324 : Gerbe, Brulin, Makrini, Legraverend, Jay: DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium. in Gastroenterology 2009 (PubMed)
    Show all 12 Pubmed References

  2. Human Polyclonal DCLK1 Primary Antibody für WB - ABIN391323 : Matsumoto, Pilz, Ledbetter: Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS). in Genomics 1999 (PubMed)
    Show all 8 Pubmed References

Weitere Antikörper gegen DCLK1 Interaktionspartner

Zebrafish Doublecortin-Like Kinase 1 (DCLK1) Interaktionspartner

  1. These results suggest that both the kinase domain and the Ser (zeige SIGLEC1 Antikörper)/Pro-rich domain are involved in regulating the microtubule-binding activity of doublecortin (zeige DCX Antikörper)-like protein kinase (zeige TGFB3 Antikörper) (DCLK (zeige DCLK2 Antikörper)).

  2. DCLK (zeige DCLK2 Antikörper) mediates its neuronal functions through phosphorylation of physiological substrates such as synapsin II (zeige SYN2 Antikörper)

  3. Gene knockdown studies of zDCLK (zeige DCLK2 Antikörper) suggest that zDCLK (zeige DCLK2 Antikörper) may play crucial roles in the central nervous systems during the early stage of embryogenesis.

Human Doublecortin-Like Kinase 1 (DCLK1) Interaktionspartner

  1. Generated a (doublecortin like kinase 1) DCLK1-S-specific polyclonal antibody (S-isoform specific), and studied its use in screening of colon cancer after colonoscopy.

  2. DCLK1 expression was observed in tumor cells in patients with pathological stage I non-small cell lung cancer (NSCLC)and was correlated with adverse prognosis, especially in patients with adenocarcinoma. DCLK1 may be a potential new therapeutic target

  3. Biochemical and structural characterization of DCLK1 allowed for the mapping of cancer-causing mutations within the kinase domain.

  4. Our results indicate that Dclk1 is essential in advancing intestinal tumorigenesis. Knocking down Dclk1 decreases tumor stemness and progression and is thus predicted to regulate pro-survival signaling and tumor cell pluripotency.

  5. The univariate and multivariate analyses suggested DCAMKL1 protein overexpression was an unfavorable prognostic factor in bladder cancer patients. In conclusion, DCAMKL1 is an independent poor prognostic factor for bladder cancer patients.

  6. DCLK1 induction and its overexpression following hepatic injury are likely to contribute to tumorigenesis including maintenance and dissemination of tumor cells in circulation.

  7. first evidence for the suppressive activity of miR (zeige MLXIP Antikörper)-613 in hepatocellular carcinoma, which is causally linked to targeting of DCLK1

  8. MSX1 (zeige MSX1 Antikörper) and DCLK1 might be used in colorectal cancer detection or as target of cancer therapies.

  9. Increased expression of stromal DCLK1 was detected in endometriotic tissue compared to endometriosis patient endometrium. Stromal expression of DCLK1 was increased in endometrium of endometriosis patients compared to controls.

  10. DCLK1 up-regulation may play a contributory role in colorectal cancer metastasis and poor prognosis via activation of EMT (zeige ITK Antikörper). DCLK1 may serve as an independent predictor for CRC (zeige CALR Antikörper) prognosis.

Mouse (Murine) Doublecortin-Like Kinase 1 (DCLK1) Interaktionspartner

  1. Dclk1 contributes functionally to the pathogenesis of pancreatic cancer; Dclk1 marks quiescent pancreatic progenitors that are candidates for the origin of pancreatic cancer

  2. loss of parietal cells leads to the reversible emergence of a novel Dclk1-expressing sensory cell population in the gastric mucosa.

  3. Dclk1 plays an important role in regulating colonic inflammatory response and colonic epithelial integrity

  4. Dclk1 promotes axonal regeneration, neuronal survival, and growth core reformation via microtubule stabilization, prevention of F-actin destabilization and synergy with mTOR (zeige FRAP1 Antikörper).

  5. Dclk1 is critically involved in facilitating intestinal tumorigenesis by enhancing pluripotency and EMT (zeige ITK Antikörper) factors in Apc (zeige APC Antikörper) mutant intestinal tumors and it also provides a potential therapeutic target for the treatment of colorectal cancer.

  6. Dclk1 plays a functional role critical in the epithelial restorative response.

  7. DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer.

  8. These results suggest that crypt epithelial cell Dclk1 expression can be used as one potential marker to evaluate the early survival of intestinal stem cells following severe radiation injury.

  9. Pancreatic neoplasms in mice contain morphologically and functionally distinct subpopulations, expressing DCLK1, that have cancer stem cell-like properties.

  10. DCAMKL1 represses osteoblast activation by antagonizing Runx2 (zeige RUNX2 Antikörper), the master transcription factor in osteoblasts.

DCLK1 Antigen-Profil

Protein Überblick

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.

Genbezeichner und Symbole assoziert mit DCLK1

  • doublecortin-like kinase 1 (DCLK1) Antikörper
  • doublecortin-like kinase 1a (dclk1a) Antikörper
  • doublecortin-like kinase 2 (dclk2) Antikörper
  • doublecortin-like kinase 1 (Dclk1) Antikörper
  • 1700113D08Rik Antikörper
  • 2810480F11Rik Antikörper
  • AI836758 Antikörper
  • Ania4 Antikörper
  • CL1 Antikörper
  • Click-I Antikörper
  • CLICK1 Antikörper
  • Cpg16 Antikörper
  • Dcamkl1 Antikörper
  • DCDC3A Antikörper
  • Dcl Antikörper
  • Dclk Antikörper
  • dclk1 Antikörper
  • MGC145348 Antikörper
  • mKIAA0369 Antikörper
  • wu:fc51f11 Antikörper
  • zgc:153709 Antikörper

Bezeichner auf Proteinebene für DCLK1

doublecortin-like kinase 1 , doublecortin and CaM kinase-like 1 , doublecortin and calcium/calmodulin-dependent protein kinase-like 1 , serine/threonine-protein kinase DCLK1 , doublecortin-like kinase 2 , serine/threonine-protein kinase DCLK1-like , doublecortin domain-containing protein 3A , doublecortin-like and CAM kinase-like 1 , CLICK-I beta , double cortin and calcium/calmodulin-dependent protein kinase-like 1

GENE ID SPEZIES
467259 Pan troglodytes
477304 Canis lupus familiaris
558997 Danio rerio
587664 Strongylocentrotus purpuratus
613449 Bos taurus
733926 Xenopus (Silurana) tropicalis
100401876 Callithrix jacchus
100484701 Ailuropoda melanoleuca
100062396 Equus caballus
100080521 Ornithorhynchus anatinus
100443787 Pongo abelii
100539645 Meleagris gallopavo
100607261 Nomascus leucogenys
9201 Homo sapiens
13175 Mus musculus
83825 Rattus norvegicus
100521679 Sus scrofa
418903 Gallus gallus
100725335 Cavia porcellus
Ausgewählte Anbieter für anti-DCLK1 (DCLK1) Antikörper
Haben Sie etwas anderes gesucht?