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DCDC2 encodes a doublecortin domain-containing family member. Zusätzlich bieten wir Ihnen DCDC2 Antikörper (96) und DCDC2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
Study identified biallelic missense mutations or in-frame deletion in DCDC2 in children affected with neonatal sclerosi. Mutations involve highly conserved amino acids in the doublecortin (zeige DCX ELISA Kits) domains of the protein. In cholangiocytes, DCDC2 protein is normally located in the cytoplasm and cilia, whereas in patients the mutated protein is accumulated in the cytoplasm, absent from cilia, and associated with ciliogenesis defect.
Developmental dyslexia genetic (DCDC2) and environmental factors (smoke and miscarriage) underlie ADHD traits supporting a potential pleiotropic effect.
that endogenous DYX1C1 (zeige DYX1C1 ELISA Kits) localizes to the base of the cilium, whereas DCDC2 localizes along the entire axoneme of the cilium
DCDC2 Polymorphism is associated with reading disability.
off-target, non-immune mediated effects of the mTOR (zeige FRAP1 ELISA Kits)-inhibitor everolimus on the podocyte cytoskeleton might involve regulation of microtubules, revealing a potential novel role of TUBB2B (zeige TUBB2B ELISA Kits) and DCDC2 in glomerular podocyte development
This study demonstrated that DCDC2 intron 2 deletion impair illusory visual motion perception-specifically processed by the magnocellular-dorsal (M-D) stream-is impaired in children with Developmental dyslexia.
A nonsynonymous polymorphism in DCDC2 (corrected P = 0.002) and a noncoding variant in S100B (zeige S100B ELISA Kits) (corrected P = 0.016) showed a significant association with spelling performance in families of German origin.
Our results reveal DCDC2a to be a deafness gene and a player in hair cell kinocilia and supporting cell (zeige PTPRJ ELISA Kits) primary cilia length regulation likely via its role in microtubule formation and stabilization.
the association of DCDC2 and KIAA0319 (zeige KIAA0319 ELISA Kits) with Developmental dyslexia in Chinese population should be further validated
In a population carrying a deletion in the DCDC2 gene, impaired motion perception was identified in subjects with dyslexia.
Behavioral results revealed deficits in rapid auditory processing, working memory and reference memory in Dcdc2(del2/del2) mice when compared with matched wild types.
Results link the function of the dyslexia-associated gene Dcdc2 to spike timing through activity of N-methyl-D-aspartate receptor (zeige GRIN1 ELISA Kits) (NMDAR (zeige GRIN1 ELISA Kits))
These results indicate that Dcdc2 is not required for neurogenesis, neuronal migration or differentiation in mice, but may have partial functional redundancy with doublecortin (zeige DCX ELISA Kits).
heterozygous and homozygous mutations of Dcdc2 result in persistent visuo-spatial memory deficits, as well as visual discrimination and long-term memory deficits
This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
doublecortin domain containing 2
, doublecortin domain-containing protein 2
, doublecortin domain-containing protein 2-like