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Involved in regulating eumelanin and phaeomelanin levels. Zusätzlich bieten wir Ihnen DCT Antikörper (101) und DCT Kits (33) und viele weitere Produktgruppen zu diesem Protein an.
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MIF-2 (zeige HSPA5 Proteine)/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI (zeige SLPI Proteine)- and ATF4 (zeige ATF4 Proteine)-dependent mechanisms.
the slaty mutant melanocytes seem to be more sensitive to ultraviolet rays and oxidative stress than black melanocytes.
A novel murine model of vitiligo (zeige MITF Proteine) is established by sequential prime/boost immunizations into the hind footpad and tail dermis with tyrosinase-related protein 2 (TRP2)-180 (SVYDFFVWL) peptide.
study indicates that tumor antigen (TRP2) expressed in MCMV induces a strong and long-lasting anti-melanoma effect through an antibody-dependent mechanism
Vaccine formulations with synthetic long peptides for treating B16F10 skin melanoma fails to elicit strong CD8 (zeige CD8A Proteine) T cell responses to self-differentiation antigens TRP-2 and gp100 (zeige PMEL Proteine).
level of gene targeting was not improved by the DSB induction, indicating a limited capacity of I-SceI to mediate homologous recombination at the Dct locus
Recombinant dopachrome tautomerase was expressed and purified, without its carboxy-terminal transmembrane region. Analysis of dopachrome tautomerase tryptic peptides by MALDI-TOF/TOF (zeige FEZF2 Proteine) determined N-glycosylation as a primary post-translational modification.
Dopachrome tautomerase inactivation elevates the level of ROS (zeige ROS1 Proteine), increases the numbers of sunburn cells and apoptotic cells, and decreases the amount of eumelanin in the epidermis upon exposure to chronic UVA radiation
the TRP-2 polypeptide folds in the endoplasmic reticulum (ER) in the presence of calnexin (zeige CANX Proteine), until it reaches a dithiothreitol-resistant conformation enabling its ER exit to the Golgi
Results describe the generation of a knockout of the dopachrome tautomerase gene in mice with effects restricted to pigment production and coat color.
High DCT expression is associated with HPV16 Infection.
Data indicate that the caveolin-1 (CAV1 (zeige CAV1 Proteine)) control on dopachrome tautomerase (DCT) gene expression, DCT post-translational processing, and subcellular distribution is cell phenotype-dependent.
The effect of DCT on UVR DNA damage responses and survival pathways in melanocytes was examined by knockdown experiments using melanoma cells, neonatal melanoblasts in monoculture and in co-culture with keratinocytes.
Report dopachrome tautomerase expression in mealanocytic tumors.
The results suggested that the miRNAs may be involved in MITF (zeige MITF Proteine) regulation of TYR (zeige TYR Proteine), TYRP1 (zeige TYRP1 Proteine) and TYRP2, which provides a new clue for understanding the role of miRNAs in melanocyte dysfunctional disease.
Data suggest that macrophage migration inhibitory factor (MIF (zeige MIF Proteine)) and d-dopachrome tautomerase (zeige DDT Proteine) (d-DT) act cooperatively to inhibit steady-state phosphorylation and activation of AMPK (zeige PRKAA1 Proteine) in LKB1 (zeige STK11 Proteine) wild type and LKB1 (zeige STK11 Proteine) mutant non-small cell lung carcinomas cells.
human TRP2 counteracts apoptotic cell death induction, possibly by means of its L-dopachrome tautomerase activity, and negatively affects the p53 (zeige TP53 Proteine) pathway
Trp2 SNP2 allele is a risk factor for the development and severity of degenerative disc disease in a Chinese Han population.
Data suggest that OTX2 (zeige OTX2 Proteine) may regulate retinal pigment epithelium (RPE (zeige RPE Proteine))-specific target genes, such as DOPAchrome tautomerase (DCT), thereby maintaining the homeostasis of RPE (zeige RPE Proteine).
Because TRP-2(181-190) overlaps with the known HLA-A*0201-presented epitope TRP-2(180-188), an 11mer peptide encompassing both epitopes might be of specific value for vaccination of a broad population of melanoma patients.
Involved in regulating eumelanin and phaeomelanin levels.
, L-dopachrome Delta-isomerase
, L-dopachrome tautomerase
, dopachrome delta isomerase
, dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
, tyrosinase related protein 2
, tyrosinase-related protein 2
, L-dopachrome tautomerase-like
, SLATY locus protein
, tyrosinase-related protein-2
, dopachrome delta-isomerase
, tyrosine-related protein 2