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Dihydrolipoyl Transacetylase Proteine (DLAT)

DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). Zusätzlich bieten wir Ihnen Dihydrolipoyl Transacetylase Antikörper (54) und Dihydrolipoyl Transacetylase Kits (10) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
DLAT 1737 P10515
DLAT 81654 P08461
DLAT 235339 Q8BMF4
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Showing 8 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
609,52 €
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HOST_Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
700,95 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.418,73 €
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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Human Unkonjugiert   2 μg Anmelden zum Anzeigen 10 bis 11 Tage
186,70 €
Details

DLAT Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Rat (Rattus)

Mouse (Murine) ,

Weitere Proteine zu Dihydrolipoyl Transacetylase (DLAT) Interaktionspartnern

Human Dihydrolipoyl Transacetylase (DLAT) Interaktionspartner

  1. DLAT interacts with C1QBP (zeige C1QBP Proteine) in mitochondria.

  2. ongoing activation of PDCE2-specific B-cells in primary biliary cirrhosis

  3. Results show that DLAT and ACAT2 (zeige ACAT2 Proteine) as upstream acetyltransferases of K76 and K294 in 6PGD (zeige PGD Proteine) protein.

  4. These findings were used to identify potentially antigenic sequences within PDC-E2 (an important hepatic autoantigen) that contain a DR0801 motif.

  5. Solution structure and characterisation of the human pyruvate dehydrogenase (zeige PDP Proteine) complex core assembly

  6. Data suggest that the catalytic site of pyruvate dehydrogenase (zeige PDP Proteine) complex E2 rather than the previously reported lipoyl binding peptide (zeige HP Proteine) may contain immunodominant epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis.

  7. a novel HLA-A*0201-restricted epitope PDC-E2 165 to 174 was defined in patients with primary biliary cirrhosis.

  8. study of facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase

  9. model of the pyruvate dehydrogenase (zeige PDP Proteine) complex formed by E2 and E2 plus the E3-binding protein (zeige PDHX Proteine) and binding of the E1 and E3 components

  10. Having found that there is an excellent and almost unique match between the PDC-E2 autoepitope and a sequence in mycobacterial hsp65s, we tested the corresponding peptides for cross-reactivity using sera from 90 Spanish and British PBC patients.

Zebrafish Dihydrolipoyl Transacetylase (DLAT) Interaktionspartner

  1. Deficiency of dihydrolipoamide S-acetyltransferase (Dlat) results in neurological dysfunction, congenital lactic acidosis, growth retardation, and early death.

Mouse (Murine) Dihydrolipoyl Transacetylase (DLAT) Interaktionspartner

  1. breach of tolerance to PDC-E2 is probably the first event in the natural history of primary biliary cirrhosis in genetically susceptible hosts.

  2. a novel function of pyruvate dehydrogenase (zeige PDP Proteine) complex E2 in the nucleus in up-regulating the transactivating ability of STAT5 (zeige STAT5A Proteine)

Dihydrolipoyl Transacetylase (DLAT) Protein Überblick

Protein Überblick

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

Genbezeichner und Symbole assoziert mit DLAT

  • CG5261 gene product from transcript CG5261-RB (CG5261)
  • dihydrolipoamide S-acetyltransferase (dlat)
  • dihydrolipoamide S-acetyltransferase (DLAT)
  • dihydrolipoamide S-acetyltransferase (Dlat)
  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (dlat)
  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat)
  • 6332404G05Rik Protein
  • anon-WO0118547.121 Protein
  • DLAT Protein
  • DLTA Protein
  • Dmel\\CG5261 Protein
  • EP(2)0816 Protein
  • EP816 Protein
  • PDC-E2 Protein
  • PDCE2 Protein
  • wu:fc14f10 Protein
  • wu:fc21f08 Protein
  • wu:fc86g11 Protein
  • wu:fj57d06 Protein

Bezeichner auf Proteinebene für DLAT

CG5261-PA , CG5261-PB , CG5261-PC , CG5261-PD , CG5261-PE , CG5261-PF , Dihydrolipoyllysine-residue acetyltransferase , dihydrolipoamide acetyltransferase , dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) , 70 kDa mitochondrial autoantigen of primary biliary cirrhosis , E2 component of pyruvate dehydrogenase complex , M2 antigen complex 70 kDa subunit , PBC , dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex , dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial , dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial , pyruvate dehydrogenase complex component E2 , dihydrolipoyllysine-residue acetyltransferase , E2 , PDC-E2 , PDCE2 , fc86g11 , fj57d06 , no optokinetic nystagmus a , no optokinetic response b , noa , nrb

GENE ID SPEZIES
34021 Drosophila melanogaster
398314 Xenopus laevis
419796 Gallus gallus
1737 Homo sapiens
489406 Canis lupus familiaris
397054 Sus scrofa
512723 Bos taurus
81654 Rattus norvegicus
100349212 Oryctolagus cuniculus
324201 Danio rerio
235339 Mus musculus
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