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DHDH encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. Zusätzlich bieten wir Ihnen DHDH Antikörper (48) und DHDH Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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Some genetical studies show also altered expression of the dehydrogenases ALDH2 (zeige ALDH2 Proteine) and DHDH genes in patients with Dupuytren's disease and with digestive tract malignancies related to alcohol abuse.(review)
Possible association of both variants of the DHDH gene with familial Dupuytren's disease, as over-representation of the rs2270941 and rs11666105 alterations was identified among 100 patients with a familial history.
Survival was significantly better in gastric cancer patients with low DDH (zeige DDH Proteine) expression.
Site-directed mutagenesis of conserved residues shows that Tyr (zeige TYR Proteine)-180 plays a critical role in the catalytic function of this enzyme, while His-79 is required in the coenzyme binding and chemical steps of the reaction.
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction.
dimeric dihydrodiol dehydrogenase
, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
, dihydrodiol dehydrogenase (dimeric)
, 3-deoxyglucosone reductase
, D-xylose 1-dehydrogenase
, D-xylose-NADP dehydrogenase
, xylose dehydrogenase 1