Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) ELISA Kits

DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen DEF6 Antikörper (68) und DEF6 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Maus DEF6 DEF6 23853 Q8C2K1
Anti-Human DEF6 DEF6 50619 Q9H4E7
Anti-Ratte DEF6 DEF6 309642  
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Weitere ELISA Kits für DEF6 Interaktionspartner

Zebrafish Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) Interaktionspartner

  1. Swap70b and Def6a delineate Wnt11 (zeige WNT11 ELISA Kits) and Wnt5b (zeige WNT5B ELISA Kits) signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation

  2. def6 morphants phenocopy Wnt5b (zeige WNT5B ELISA Kits) mutants and ectopic overexpression of def6 essentially rescues Wnt5b (zeige WNT5B ELISA Kits) morphants, indicating a novel role for def6 as a central GEF downstream of Wnt5b (zeige WNT5B ELISA Kits) signaling

Mouse (Murine) Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) Interaktionspartner

  1. DEF6 and SWAP70 (zeige SWAP70 ELISA Kits) are SWEF proteins with important contributors to hematopoietic stem and precursor cells biology

  2. this study identifies Def6 as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions

  3. These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.

  4. SLAT is an IP3R1 (zeige ITPR1 ELISA Kits)-interacting protein required for T cell activation.

  5. PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes.

  6. Data suggest that SLAT acts as a negative modulator of RANKL (zeige TNFSF11 ELISA Kits)-induced osteoclastogenesis.

  7. SLAT-mediated nuclear factor of activated T-cell (zeige NFATC3 ELISA Kits) (NFAT)1 (zeige NFAT1 ELISA Kits) activation is required for efficient expansion of CD8 (zeige CD8A ELISA Kits)+ T cells during the primary response but is not necessary for cytotoxic T lymphocyte (CTL) differentiation.

  8. SLAT/Def6 plays a major role in the T cell-mediated autoimmune processes that bring about the inflammatory eye disease, experimental autoimmune uveitis.

  9. plays a role in Th2 development and/or activation, perhaps by interfering with ZAP-70 (zeige ZAP70 ELISA Kits) signaling

  10. tyrosine-phosphorylation-mediated relocalization of SLAT to the site of antigen recognition is required for SLAT to exert its pivotal role in NFAT (zeige NFATC1 ELISA Kits)-dependent CD4 (zeige CD4 ELISA Kits)(+) T cell differentiation.

Human Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) Interaktionspartner

  1. this study identifies Def6 (zeige DEFA6 ELISA Kits) as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions

  2. DEF6 expression may serve as an independent prognostic factor, and interacted positively with p16 toward high tumor stage and shorter survival.

  3. IBP (zeige TSPO ELISA Kits) was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases

  4. DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.

  5. Molecular cloning of IBP (zeige TSPO ELISA Kits), a guanine nucleotide exchange factor (zeige RASGRF1 ELISA Kits), which is highly expressed in the immune system.

  6. IBP (zeige TSPO ELISA Kits) is a novel guanine nucleotide exchange factor (zeige RASGRF1 ELISA Kits) and is recruited to the immunological synapse by T cell receptor engagement

  7. DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function

  8. Overexpression of the Interferon regulatory factor 4 (zeige IRF4 ELISA Kits)-binding protein is associated with Colorectal Carcinoma.

  9. DEF6 (zeige DEFA6 ELISA Kits), a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42 (zeige CDC42 ELISA Kits), and RhoA (zeige RHOA ELISA Kits).

DEF6 Antigen-Profil

Beschreibung des Gens

DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003

Genbezeichner und Symbole assoziert mit DEF6

  • differentially expressed in FDCP 6 homolog (mouse) (DEF6) Antikörper
  • differentially expressed in FDCP 6a homolog (mouse) (def6a) Antikörper
  • differentially expressed in FDCP 6 homolog (def6) Antikörper
  • differentially expressed in FDCP 6 homolog (LOC100498543) Antikörper
  • differentially expressed in FDCP 6 (Def6) Antikörper
  • differentially expressed in FDCP 6 homolog (mouse) (Def6) Antikörper
  • 2410003F05Rik Antikörper
  • 6430538D02Rik Antikörper
  • AV094905 Antikörper
  • Def6 Antikörper
  • IBP Antikörper
  • MGC68775 Antikörper
  • SLAT Antikörper
  • Slat2 Antikörper
  • Slat6 Antikörper
  • SWAP70L Antikörper
  • zgc:63721 Antikörper

Bezeichner auf Proteinebene für DEF6

differentially expressed in FDCP 6 homolog (mouse) , differentially expressed in FDCP 6 homolog , DEF-6 , IRF-4-binding protein , IRF4-binding protein , SWAP-70-like adapter of T-cells , SWAP-70-like adaptor protein of T cells

GENE ID SPEZIES
419893 Gallus gallus
462636 Pan troglodytes
394015 Danio rerio
398924 Xenopus laevis
100498543 Xenopus (Silurana) tropicalis
100053351 Equus caballus
23853 Mus musculus
50619 Homo sapiens
608163 Canis lupus familiaris
100154998 Sus scrofa
516457 Bos taurus
309642 Rattus norvegicus
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