anti-Deoxycytidine Kinase (DCK) Antikörper

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Zusätzlich bieten wir Ihnen DCK Proteine (16) und DCK Kits (15) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
DCK 1633 P27707
DCK 13178 P43346
DCK 79127 P48769
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Top anti-DCK Antikörper auf antikoerper-online.de

Showing 10 out of 138 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-DCK Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Human heart 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-DCK Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>721_B cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IF, IHC (p), IP, WB The anti-DCK Pab (ABIN391125) is used in Western blot to detect DCK in mouse intestine tissue lysate. Deoxycytidine kinase(DCK) immunoprecipitated from H460cells with 7.5ug (microgram) of the dCK antibody (ABIN391125) using the Pierce classic mammalian IP kit (#45217) reagent as described as manufacturer instructions (lane 1, 3) and Current Protocols in Cell Biology, 1998, 7.2.1-7.2.21. Proteins separated on a 12% SDS gel, transferred to a PVDF membrane and probed with 1:700 dilution of DCK antibody (ABIN391125). Bands were detected using enhanced chemiluminescence (SuperSignal West Pico Chemiluminescent Substrate Kit). No specific reagents were employed to remove IgG from immunoprecipitated sample. Data courtesy of Dr. Stacy Shord, University of Illinois, Chicago. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Maus Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cell lines, using DCK antibody. 100 μL Anmelden zum Anzeigen 13 bis 14 Tage
$302.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$368.50
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Maus Unkonjugiert FACS, IF, IHC, WB HEK293T cells transfected with either RC210767 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-DCK antibody (ABIN2454431), and then analyzed by flow cytometry. Anti-DCK mouse monoclonal antibody (ABIN2454431) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY DCK (RC210767). 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$423.50
Details
Human Maus Unkonjugiert FACS, WB HEK293T cells transfected with either RC210767 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-DCK antibody (ABIN2454398), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DCK (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-DCK. 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$423.50
Details
Human Maus Unkonjugiert FACS, IF, WB HEK293T cells transfected with either RC210767 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-DCK antibody (ABIN2454451), and then analyzed by flow cytometry. Anti-DCK mouse monoclonal antibody (ABIN2454451) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY DCK (RC210767). 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$423.50
Details
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged DCK is approximately 0.3ng/ml as a capture antibody. Western Blot detection against Immunogen (36.74 KDa) . 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details

DCK Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-DCK Antikörper

  1. Human Polyclonal DCK Primary Antibody für IF, IHC (p) - ABIN391125 : Hartford, Duan, Delaney, Mi, Kistner, Lamba, Huang, Dolan: Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity. in Blood 2009 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal DCK Primary Antibody für IHC - ABIN965975 : Krawiec, Kierdaszuk, Shugar: Inorganic tripolyphosphate (PPP(i)) as a phosphate donor for human deoxyribonucleoside kinases. in Biochemical and biophysical research communications 2003 (PubMed)
    Show all 4 Pubmed References

  3. Cow (Bovine) Polyclonal DCK Primary Antibody für WB - ABIN2784622 : Iyidogan, Lutz: Systematic exploration of active site mutations on human deoxycytidine kinase substrate specificity. in Biochemistry 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal DCK Primary Antibody für ELISA, WB - ABIN514896 : Funel, Giovannetti, Del Chiaro, Mey, Pollina, Nannizzi, Boggi, Ricciardi, Del Tacca, Bevilacqua, Mosca, Danesi, Campani: Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma. in Laboratory investigation; a journal of technical methods and pathology 2008 (PubMed)

  5. Human Monoclonal DCK Primary Antibody für IF, ELISA - ABIN514902 : Costantino, Witkiewicz, Kuwano, Cozzitorto, Kennedy, Dasgupta, Keen, Yeo, Gorospe, Brody: The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase. in Cancer research 2009 (PubMed)

Weitere Antikörper gegen DCK Interaktionspartner

Human Deoxycytidine Kinase (DCK) Interaktionspartner

  1. Phosphorylated and activated DCK can inhibit radiation-induced cell death including apoptosis and mitotic catastrophe, and promote radiation-induced autophagy through PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) pathway.

  2. Low deoxycytidine kinase expression is associated with periampullary adenocarcinoma.

  3. recently described a human deoxycytidine kinase mutant (G12 (zeige TCF3 Antikörper)) that sensitizes cancer cell lines to treatment with gemcitabine. Here, starting from the G12 (zeige TCF3 Antikörper) variant, we identified a mutant that triggers even greater sensitisation to gemcitabine than G12 (zeige TCF3 Antikörper).

  4. RNA expression of deoxycytidine kinase (DCK), human equilibrative nucleoside transporter-1 (ENT1 (zeige SLC29A1 Antikörper)) and ribonucleotide reductase M1 (RRM1 (zeige RRM1 Antikörper)) were significantly higher and cytidine deaminase (CDA (zeige CDA Antikörper)) was significantly lower in ex vivo Ara (zeige FOXC1 Antikörper)-C sensitive samples.

  5. n the multivariate Cox (zeige COX8A Antikörper) regression analysis, we found that age at diagnosis, wild-type genotype of the CDA (zeige CDA Antikörper) A79C polymorphism, and wild-type genotype of the dCK C360G polymorphism were the most significant prognostic factors for predicting the risk of death

  6. results strongly suggest that (1) the E197K alteration in DCK causes inactivation of DCK, and that (2) loss of the normal E197 allele is the crucial mechanism in acquisition of gemcitabine resistance in the RMKN28 tumor cell line

  7. DCK rs12648166 and DCK rs4694362 SNPs were associated with hematologic toxicity (OR = 2.63, CI 95% = 1.37-5.04, P = 0.0036 and OR = 2.53, CI 95% = 1.34-4.80, P = 0.0044, respectively).

  8. These findings indicate that the decitabine metabolic pathway affects its therapeutic effects, lower hENT1 expression may induce primary resistance and down-regulated DCK expression may be related to secondary resistance.

  9. DCK expression levels are prognostic and had predictive value for sensitivity to 5-FU in pancreatic cancer.

  10. DCK could regulate the migration and invasion of fibroblast-like synoviocytes through AKT (zeige AKT1 Antikörper) pathway in rheumatoid arthritis patients.

Mouse (Murine) Deoxycytidine Kinase (DCK) Interaktionspartner

  1. Mutation of a single serine 74 residue has profound effects on murine T and B lymphocyte (zeige AKAP17A Antikörper) development, suggesting that post-translational regulation of dCK has a role in maintaining genomic stability during hematopoiesis.

  2. activating the dAdo-DCK-dATP pathway directly results in increased apoptosis in the lungs of mice with air-space enlargement and suggests a novel therapeutic target for the treatment of COPD (zeige ARCN1 Antikörper)

  3. Deoxycytidine kinase is a new regulator of hematopoietic integrity and lymphocyte quiescence and survival.

  4. The severe impact of dCK inactivation on lymphopoiesis was unexpected given that nucleoside salvage has been thought to play a limited, "fine-tuning" role in regulating deoxyribonucleotide triphosphate pools produced by the de novo pathway.

DCK Antigen-Profil

Protein Überblick

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.

Genbezeichner und Symbole assoziert mit DCK

  • deoxycytidine kinase (dck) Antikörper
  • deoxycytidine kinase, gene 2 L homeolog (dck.2.L) Antikörper
  • deoxycytidine kinase, gene 2 (dck.2) Antikörper
  • deoxycytidine kinase (DCK) Antikörper
  • zgc:110540 (zgc:110540) Antikörper
  • Deoxycytidine kinase (FPV059) Antikörper
  • Deoxycytidine kinase (FPV151) Antikörper
  • deoxycytidine kinase (Dck) Antikörper
  • deoxycytidine kinase, gene 1 L homeolog (dck.1.L) Antikörper
  • Dck Antikörper
  • dck1 Antikörper
  • dck2 Antikörper
  • wu:fc15f06 Antikörper
  • wu:fe11h12 Antikörper
  • wu:fj05e11 Antikörper
  • zgc:101771 Antikörper
  • zgc:109951 Antikörper

Bezeichner auf Proteinebene für DCK

Deoxycytidine kinase , deoxycytidine kinase , deoxynucleoside kinase , deoxycytidine kinase 1 , deoxyribonucleoside kinase

GENE ID SPEZIES
100196160 Salmo salar
446773 Xenopus laevis
549546 Xenopus (Silurana) tropicalis
100305233 Oncorhynchus mykiss
461273 Pan troglodytes
705040 Macaca mulatta
541538 Danio rerio
1486607 Fowlpox virus
1486699 Fowlpox virus
1633 Homo sapiens
13178 Mus musculus
474325 Danio rerio
422648 Gallus gallus
482188 Canis lupus familiaris
530642 Bos taurus
79127 Rattus norvegicus
496391 Xenopus laevis
Ausgewählte Anbieter für anti-DCK (DCK) Antikörper
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