Deleted in Bladder Cancer 1 Proteine (DBC1)

DBC1 is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers.

alle Proteine anzeigen Gen GeneID UniProt
Human DBC1 DBC1 1620 O60477
Ratte DBC1 DBC1 140610 Q925T8
Maus DBC1 DBC1 56710 Q920P3
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Weitere Proteine zu Deleted in Bladder Cancer 1 (DBC1) Interaktionspartnern

Human Deleted in Bladder Cancer 1 (DBC1) Interaktionspartner

  1. we found that the SIRT1 (zeige SIRT1 Proteine) modulators AROS (zeige RPS19BP1 Proteine) and DBC1 have an impact on hsp70 (zeige HSP70 Proteine) transcription, HSF1 (zeige HSF1 Proteine) acetylation status, and HSF1 (zeige HSF1 Proteine) recruitment to the hsp70 (zeige HSP70 Proteine) promoter

  2. DBC1 modulates the stability and function of the nuclear receptor Rev-erb-alpha (zeige NR1D1 Proteine).

  3. the stress-induced DBC1-SIRT1 (zeige SIRT1 Proteine) interaction is important for cell fate determination following genotoxic stress.

  4. Rxpression of DBC1 and SIRT1 (zeige SIRT1 Proteine) is a significant prognostic indicator for breast carcinoma patients.

  5. High DBC1 expression is associated with breast and lung cancer..

  6. DBCCR1 is involved in the process of bladder tumorigenesis

  7. the prevalent inactivation of DBCCR1 seen at the expression level in astrocytomas is not primarily caused by genomic loss of the gene.

  8. hypermethylation of the DBC1 promoter region is a frequent event during the development of lymphoproliferative malignancies

Mouse (Murine) Deleted in Bladder Cancer 1 (DBC1) Interaktionspartner

  1. Brinp1 plays an important role in normal brain development and function by influencing neuronal distribution within the cortex.

  2. DBC1 loss results in less p53 (zeige TP53 Proteine) protein in vitro and in vivo.

  3. inhibits B cell function by selectively suppressing the transcriptional activity of alternative NF-kappaB (zeige NFKB1 Proteine) pathway upon CD40 (zeige CD40 Proteine) stimulation

  4. Absence of BRINP1 causes deregulation of neurogenesis and impairments of neuronal differentiation in adult hippocampal circuitry.

  5. Data show that neuron-restrictive silencing factor (NRSF) plays a role in the neural-selective expression of BMP/RA-inducible neural-specific protein 1 (zeige DPYSL3 Proteine).

  6. From these results, the physiological roles of the activity-dependent induction of BRINP1-mRNA are discussed.

  7. The authors show that retinoic acid-inducible gene (RIG)-I (zeige DDX58 Proteine)-like receptors (RLRs) in cooperation with Toll (zeige TLR4 Proteine)-like receptor (TLR) 9 (zeige TLR9 Proteine) is required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV).

Deleted in Bladder Cancer 1 (DBC1) Protein Überblick

Protein Überblick

This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.

Genbezeichner und Symbole assoziert mit DBC1

  • deleted in bladder cancer 1 (DBC1)
  • deleted in bladder cancer 1 (LOC100340025)
  • bone morphogenetic protein/retinoic acid inducible neural-specific 1 (BRINP1)
  • bone morphogenetic protein/retinoic acid inducible neural-specific 1 (Brinp1)
  • bone morphogenic protein/retinoic acid inducible neural specific 1 (Brinp1)
  • BRINP Protein
  • Dbc1 Protein
  • Dbccr1 Protein
  • Fam5a Protein

Bezeichner auf Proteinebene für DBC1

deleted in bladder cancer 1 , deleted in bladder cancer protein 1-like , bA574M5.1 (deleted in bladder cancer chromosome region candidate 1 (IB3089A)) , bone morphogenic protein/retinoic acid inducible neural-specific 1 , deleted in bladder cancer chromosome region candidate 1 , deleted in bladder cancer protein 1 , BMP/retinoic acid-inducible neural-specific protein 1 , deleted in bladder cancer protein 1 homolog , BMP/retinoic acid-inducible neural-specific protein (BRINP) , BMP/retinoic acid-inducible neural-specific protein-1

GENE ID SPEZIES
100066915 Equus caballus
464694 Pan troglodytes
481694 Canis lupus familiaris
100340025 Oryctolagus cuniculus
100386113 Callithrix jacchus
100457605 Pongo abelii
100602071 Nomascus leucogenys
1620 Homo sapiens
140610 Rattus norvegicus
56710 Mus musculus
395098 Gallus gallus
100625235 Sus scrofa
538990 Bos taurus
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