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DACH2 is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. Zusätzlich bieten wir Ihnen DACH2 Proteine (3) und DACH2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) Polyclonal DACH2 Primary Antibody für ELISA, WB - ABIN314279
Wu, Yang, Wang, Davoli, DAmico, Li, Cveklova, Kozmik, Lisanti, Russell, Cvekl, Pestell: DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. in The Journal of biological chemistry 2003
Human Polyclonal DACH2 Primary Antibody für IHC, IHC (p) - ABIN4304216
Nodin, Fridberg, Uhlén, Jirström: Discovery of dachshund 2 protein as a novel biomarker of poor prognosis in epithelial ovarian cancer. in Journal of ovarian research 2012
Dach2 and Hdac9 (zeige HDAC9 Antikörper) mediate the effects of muscle activity on muscle reinnervation; Myog (zeige MYOG Antikörper) and Gdf5 (zeige GDF5 Antikörper) appear to stimulate muscle reinnervation through parallel pathways
Unlike Drosophila dachshund mutants that lack eyes and exhibit leg truncations, the eyes and limbs of Dach (zeige DACH1 Antikörper) double mutants are present, suggesting differences between Dach (zeige DACH1 Antikörper) and dachshund gene function during embryonic eye and limb formation.
a HDAC (zeige HDAC3 Antikörper)-Dach2-myogenin (zeige MYOG Antikörper) signaling pathway has been identified to decode nerve activity and control muscle gene expression in developing and adult skeletal muscle
HDAC4 (zeige HDAC5 Antikörper) is a neural activity-regulated deacetylase and a key signaling component that relays neural activity to the muscle transcriptional machinery through Dach2, myogenin (zeige MYOG Antikörper), and nAChR (zeige CHRNA4 Antikörper)
With Dach1 (zeige DACH1 Antikörper), may redundantly control female reproductive tract formation by regulating expression of target genes required for development of the Mullerian duct.
Exome sequencing in two brothers with distinct phenotype including congenital language disorder, growth retardation, intellectual disability and urinary and fecal incontinence, identifies missense mutations in ABCD1 (zeige ABCD1 Antikörper) and DACH2.
DACH2 is an independent prognostic marker that can be used at initial diagnosis of urothelial carcinoma of the bladder to identify patients who have a high potential to develop metastasis.
Most X;autosome translocations associated with premature ovarian failure do not interrupt X-linked genes. Only one of the six breakpoints disrupts a gene, DACH2.
This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene.
dachshund homolog 2
, dachshund homolog 2 (Drosophila)
, dachshund homolog 2-like
, dachshund 2