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Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2\; MIM 130610). Zusätzlich bieten wir Ihnen DPH1 Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal DPH1 Primary Antibody für WB - ABIN1042636
Prowse, Vanderveer, Milling, Pan, Dunbrack, Xu, Godwin: OVCA2 is downregulated and degraded during retinoid-induced apoptosis. in International journal of cancer. Journal international du cancer 2002
Results identified a second homozygous missense variant in DPH1, seen in four members of a founder population, and associated with autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies.
Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia.
OVCA1 could inhibit the proliferation of ovarian cancer cells by p16 (zeige CDKN2A Antikörper)/cyclin D1 (zeige CCND1 Antikörper) pathway, but not by NF-kappaB (zeige NFKB1 Antikörper)
These findings suggest that OVCA1 deficiency in the neural crest contributes to the craniofacial abnormalities in patients with MDS (zeige MECOM Antikörper).
Ovca1 is a tumor suppressor that can modify p53 (zeige TP53 Antikörper)-induced tumorigenesis and suggest that it acts as a positive regulator for cell cycle progression.
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2\; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004
DPH1 homolog (S. cerevisiae)
, diphthamide biosynthesis protein 1-like
, diptheria toxin resistance protein required for diphthamide biosynthesis-like 1
, diphthamide biosynthesis protein 1
, DPH1 homolog
, Diphthamide biosynthesis protein 1
, DPH-like 1
, DPH2-like 1
, candidate tumor suppressor in ovarian cancer 1
, diphthamide biosynthesis protein 2 homolog-like 1
, diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1
, ovarian cancer-associated gene 1 protein
, ovarian tumor suppressor candidate 1
, ovarian cancer-associated gene 1 protein homolog