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The protein encoded by DOT1L is a histone methyltransferase that methylates lysine-79 of histone H3. Zusätzlich bieten wir Ihnen DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Kits (6) und DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal DOT1L Primary Antibody für ChIP, ICC - ABIN251529
Steger, Lefterova, Ying, Stonestrom, Schupp, Zhuo, Vakoc, Kim, Chen, Lazar, Blobel, Vakoc: DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. in Molecular and cellular biology 2008
Show all 5 Pubmed References
Human Polyclonal DOT1L Primary Antibody für ICC, IF - ABIN251530
Vernimmen, Lynch, De Gobbi, Garrick, Sharpe, Sloane-Stanley, Smith, Higgs: Polycomb eviction as a new distant enhancer function. in Genes & development 2011
Human Monoclonal DOT1L Primary Antibody für IF, ELISA - ABIN566567
Phillips, Wildt, Comizzoli: Incidence of methylated histones H3K4 and H3K79 in cat germinal vesicles is regulated by specific nuclear factors at the acquisition of developmental competence during the folliculogenesis. in Journal of assisted reproduction and genetics 2016
our results identify DOT1L as a novel cofactor in N-Myc (zeige MYCN Antikörper)-mediated transcriptional activation of target genes and neuroblastoma (zeige ARHGEF16 Antikörper) oncogenesis. Furthermore, they characterize DOT1L inhibitors as novel anticancer agents against MYCN (zeige MYCN Antikörper)-amplified neuroblastoma (zeige ARHGEF16 Antikörper).
These results reveal a cooperative transcriptional activation mechanism of AEP (zeige LGMN Antikörper) and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL (zeige MLL Antikörper) fusion-AF4 complex and DOT1L for more effective treatment of MLL (zeige MLL Antikörper)-rearranged leukemia.
this indicates that DOT1L function, like MLL (zeige MLL Antikörper), does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L inhibition is sufficient to block the proliferation of MLL (zeige MLL Antikörper) fusion-induced leukemia cells of murine and human origin
DOT1L may play a critical role in DNMT3A (zeige DNMT3A Antikörper)-mutant leukemia.
DOT1L, via dimethylated histone H3 (zeige HIST3H3 Antikörper) K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 (zeige BRD4 Antikörper) to chromatin in acute lymphoblastic leukemia.
study demonstrates the development of potent DOT1L inhibitors with novel scaffolds
these findings strongly support the contention that histone methyltransferase, DOT1L-associated epigenetic changes induced by HA play pivotal roles in miR-10 (zeige LILRB2 Antikörper) production leading to up-regulation of RhoGTPase and survival proteins.
Report drug formulation/delivery of DOT1L inhibitor pinometostat in leukemia.
MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (zeige BCL11A Antikörper).
These data converge on a possible mechanism for hDot1L stimulation in which histone H2B physically 'corrals' the enzyme into a productive binding orientation.
We will highlight the structural basis of chromatin targeting of DOT1L through its cofactors and the role of DOT1L in repelling transcription repressive complexes during leukemia development.
DOT1L, via dimethylated histone H3 (zeige HIST3H3 Antikörper) K79, facilitates histone H4 (zeige HIST1H4H Antikörper) acetylation, which in turn regulates the binding of BRD4 (zeige BRD4 Antikörper) to chromatin in acute lymphoblastic leukemia.
Dot1l is a new epigenetic regulator of principal cells and intercalated cell differentiation and Atp6v1b1 (zeige ATP6V1B1 Antikörper) is a new transcriptional target of Dot1l.
results demonstrate that histone methylation, and in particular DOT1L-mediated H3K79me2 modification, drives cardiomyogenesis through the definition of a specific transcriptional landscape
Interference with DOT1L activity resulted in transcriptional activation of Atf4 (zeige ATF4 Antikörper) and Ddit3 (zeige DDIT3 Antikörper) accompanied by decreased levels of H3K79 dimethylation.
DOT1L has a role in inhibiting SIRT1 (zeige SIRT1 Antikörper)-mediated epigenetic silencing to maintain leukemic gene expression in MLL (zeige MLL Antikörper)-rearranged leukemia
Dot1L and H3K79 methylation play important roles in meiosis progression and are supposed to be associated with chromosome deacetylation of mouse oocytes.
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.
histone-lysine N-methyltransferase, H3 lysine-79 specific
, DOT1-like, histone H3 methyltransferase (S. cerevisiae)
, histone-lysine N-methyltransferase, H3 lysine-79 specific-like
, possible nucleosomal histone methylase
, DOT1-like protein
, DOT1-like, histone H3 methyltransferase
, histone H3-K79 methyltransferase
, histone methyltransferase DOT1L
, lysine N-methyltransferase 4
, DOT1-like histone H3 methyltransferase
, histone H3 methyltransferase DOT1