anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Antikörper

The protein encoded by DOT1L is a histone methyltransferase that methylates lysine-79 of histone H3. Zusätzlich bieten wir Ihnen DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Kits (6) und DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
DOT1L 84444 Q8TEK3
DOT1L 362831  
DOT1L 208266  
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Top anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Antikörper auf antikoerper-online.de

Showing 10 out of 78 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ChIP, ICC, IF, IHC (p), IP, IHC, WB Western Blot and Immunoprecipitation: DOT1L Antibody [ABIN251529] - Detection of Human DOT1L by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-DOT1L antibody ABIN251529 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate (B). DOT1L was also immunoprecipitated by another rabbit anti-DOT1L antibody and ABIN251530, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B). Immunohistochemistry-Paraffin: DOT1L Antibody [ABIN2515295] - FFPE section of human colon carcinoma.. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$486.94
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP Western Blot: DOT1L Antibody [ABIN251530] - Detection of Human DOT1L by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-DOT1L antibody ABIN251530 used for IP at 3 mcg/mg lysate. DOT1L was also immunoprecipitated by rabbit anti- DOT1L antibody ABIN251529, which recognizes an upstream epitope. Detection: Chemiluminescence with an exposure time 10 seconds. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$486.94
Details
Human Kaninchen Unkonjugiert IHC (p) Formalin-fixed and paraffin embedded human kidney labeled with Anti-DOT1L Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$295.90
Details
Human Kaninchen Unkonjugiert WB WB Image DOT1L antibody detects DOT1L protein by Western blot analysis. A. H1299 whole cell lysate/extract % SDS-PAGE DOT1L antibody , dilution: 1:1000 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Human Maus Unkonjugiert IHC, WB Immunohistochemistry: DOT1L Antibody (6E7) [NBP2-46474] - Analysis of Carcinoma of Human thyroid tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Western Blot: DOT1L Antibody (6E7) [NBP2-46474] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DOT1L. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$447.56
Details
Human Kaninchen HRP IHC (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen Unkonjugiert WB DOT1L antibody (pAb) tested by Western blot. Nuclear extract of HEK293 cells (40 µg per lane) probed with DOT1L antibody (pAb) at a dilution of 1:500. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$495.83
Details
Human Kaninchen Biotin IHC (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$383.90
Details
Human Kaninchen Unkonjugiert IHC, ELISA IHC analysis of FFPE human hepatocarcinoma tissue stained with the KMT4 antibody 0.4 mL Anmelden zum Anzeigen 2 bis 3 Tage
$411.13
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of HeLa cell line, using DOT1L antibody. 100 μL Anmelden zum Anzeigen 16 Days
$323.13
Details

DOT1L Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Antikörper

  1. Human Polyclonal DOT1L Primary Antibody für ChIP, ICC - ABIN251529 : Steger, Lefterova, Ying, Stonestrom, Schupp, Zhuo, Vakoc, Kim, Chen, Lazar, Blobel, Vakoc: DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. in Molecular and cellular biology 2008 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal DOT1L Primary Antibody für ICC, IF - ABIN251530 : Vernimmen, Lynch, De Gobbi, Garrick, Sharpe, Sloane-Stanley, Smith, Higgs: Polycomb eviction as a new distant enhancer function. in Genes & development 2011 (PubMed)

  3. Human Monoclonal DOT1L Primary Antibody für IF, ELISA - ABIN566567 : Phillips, Wildt, Comizzoli: Incidence of methylated histones H3K4 and H3K79 in cat germinal vesicles is regulated by specific nuclear factors at the acquisition of developmental competence during the folliculogenesis. in Journal of assisted reproduction and genetics 2016 (PubMed)

Weitere Antikörper gegen DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Interaktionspartner

Human DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Interaktionspartner

  1. our results identify DOT1L as a novel cofactor in N-Myc (zeige MYCN Antikörper)-mediated transcriptional activation of target genes and neuroblastoma (zeige ARHGEF16 Antikörper) oncogenesis. Furthermore, they characterize DOT1L inhibitors as novel anticancer agents against MYCN (zeige MYCN Antikörper)-amplified neuroblastoma (zeige ARHGEF16 Antikörper).

  2. These results reveal a cooperative transcriptional activation mechanism of AEP (zeige LGMN Antikörper) and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL (zeige MLL Antikörper) fusion-AF4 complex and DOT1L for more effective treatment of MLL (zeige MLL Antikörper)-rearranged leukemia.

  3. this indicates that DOT1L function, like MLL (zeige MLL Antikörper), does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L inhibition is sufficient to block the proliferation of MLL (zeige MLL Antikörper) fusion-induced leukemia cells of murine and human origin

  4. DOT1L may play a critical role in DNMT3A (zeige DNMT3A Antikörper)-mutant leukemia.

  5. DOT1L, via dimethylated histone H3 (zeige HIST3H3 Antikörper) K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 (zeige BRD4 Antikörper) to chromatin in acute lymphoblastic leukemia.

  6. study demonstrates the development of potent DOT1L inhibitors with novel scaffolds

  7. these findings strongly support the contention that histone methyltransferase, DOT1L-associated epigenetic changes induced by HA play pivotal roles in miR-10 (zeige LILRB2 Antikörper) production leading to up-regulation of RhoGTPase and survival proteins.

  8. Report drug formulation/delivery of DOT1L inhibitor pinometostat in leukemia.

  9. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (zeige BCL11A Antikörper).

  10. These data converge on a possible mechanism for hDot1L stimulation in which histone H2B physically 'corrals' the enzyme into a productive binding orientation.

Mouse (Murine) DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Interaktionspartner

  1. We will highlight the structural basis of chromatin targeting of DOT1L through its cofactors and the role of DOT1L in repelling transcription repressive complexes during leukemia development.

  2. These results reveal a cooperative transcriptional activation mechanism of AEP (zeige LGMN Antikörper) and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL (zeige MLL Antikörper) fusion-AF4 complex and DOT1L for more effective treatment of MLL (zeige MLL Antikörper)-rearranged leukemia.

  3. DOT1L may play a critical role in DNMT3A (zeige DNMT3A Antikörper)-mutant leukemia.

  4. DOT1L, via dimethylated histone H3 (zeige HIST3H3 Antikörper) K79, facilitates histone H4 (zeige HIST1H4H Antikörper) acetylation, which in turn regulates the binding of BRD4 (zeige BRD4 Antikörper) to chromatin in acute lymphoblastic leukemia.

  5. Dot1l is a new epigenetic regulator of principal cells and intercalated cell differentiation and Atp6v1b1 (zeige ATP6V1B1 Antikörper) is a new transcriptional target of Dot1l.

  6. results demonstrate that histone methylation, and in particular DOT1L-mediated H3K79me2 modification, drives cardiomyogenesis through the definition of a specific transcriptional landscape

  7. Interference with DOT1L activity resulted in transcriptional activation of Atf4 (zeige ATF4 Antikörper) and Ddit3 (zeige DDIT3 Antikörper) accompanied by decreased levels of H3K79 dimethylation.

  8. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (zeige BCL11A Antikörper).

  9. DOT1L has a role in inhibiting SIRT1 (zeige SIRT1 Antikörper)-mediated epigenetic silencing to maintain leukemic gene expression in MLL (zeige MLL Antikörper)-rearranged leukemia

  10. Dot1L and H3K79 methylation play important roles in meiosis progression and are supposed to be associated with chromosome deacetylation of mouse oocytes.

DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Antigen-Profil

Protein Überblick

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.

Genbezeichner und Symbole assoziert mit DOT1L

  • histone-lysine N-methyltransferase, H3 lysine-79 specific (LOC100116648) Antikörper
  • DOT1 like histone lysine methyltransferase (DOT1L) Antikörper
  • histone methyltransferase (DOT1) Antikörper
  • DOT1 like histone lysine methyltransferase (Dot1l) Antikörper
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (Dot1l) Antikörper
  • A630076O07 Antikörper
  • AW907654 Antikörper
  • Dot1 Antikörper
  • DOT1L Antikörper
  • KMT4 Antikörper
  • mDot1 Antikörper
  • NV11307 Antikörper

Bezeichner auf Proteinebene für DOT1L

histone-lysine N-methyltransferase, H3 lysine-79 specific , DOT1-like, histone H3 methyltransferase (S. cerevisiae) , histone-lysine N-methyltransferase, H3 lysine-79 specific-like , possible nucleosomal histone methylase , DOT1-like protein , DOT1-like, histone H3 methyltransferase , H3-K79-HMTase , histone H3-K79 methyltransferase , histone methyltransferase DOT1L , lysine N-methyltransferase 4 , DOT1-like histone H3 methyltransferase , histone H3 methyltransferase DOT1

GENE ID SPEZIES
100116648 Nasonia vitripennis
420078 Gallus gallus
100068506 Equus caballus
485073 Canis lupus familiaris
710033 Macaca mulatta
100464435 Ailuropoda melanoleuca
100619840 Monodelphis domestica
3642236 Candida albicans SC5314
84444 Homo sapiens
362831 Rattus norvegicus
208266 Mus musculus
Ausgewählte Anbieter für anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Antikörper
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