anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Antikörper

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Zusätzlich bieten wir Ihnen DNMT3A Proteine (6) und DNMT3A Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
DNMT3A 1788 Q9Y6K1
DNMT3A 444984 Q1LZ53
DNMT3A 13435 O88508
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Showing 10 out of 274 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB Western blot analysis of DNMT3A Antibody (C-term) (ABIN387865) in HepG2 cell line lysates (35 µg/lane). DNMT3A (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-DNMT3A Antibody (Center D472) (ABIN387882) in Jurkat cell line lysates (35 µg/lane).DNMT3A(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human kidney tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-Dnmt3a Pab (ABIN387881) in T47-D cell lysate. Dnmt3a (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Lysates from thymus tissue after radiation were subjected to WB using antibody against DNMT3a. CT, control animals. FR, animals subjected to fractionated exposure. AC, acutely exposed animals. All sample loading was normalized to protein content. Representative Western blots from three independent experiments are shown. each lane represents a protein extract of a thymus of one animal. (Mol. Cancer Res. 2005 Oct 01.3(10):553-561) 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-Dnmt3a Antibody (N-term R46) (ABIN387883) in Jurkat cell line lysates (35 µg/lane). Dnmt3a(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with Dnmt3a antibody (N-term R46) (ABIN387883), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of DNMT3A Antibody (Center) in HL-60 cell line lysates (35ug/lane).This demonstrates the DNMT3A antibody detected the DNMT3A protein (arrow). 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of DNMT3A Antibody (C-term) in CEM cell line lysates (35ug/lane). This demonstrates the DNMT3A antibody detected the DNMT3A protein (arrow). 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human breast carcinoma labeled with Anti-Dnmt3a Polyclonal Antibody, Unconjugated (ABIN669336) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-Dnmt3a Polyclonal Antibody, Unconjugated (ABIN669336) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
315,94 €
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Maus Unkonjugiert ChIP, CyTOF, FACS, ICC, IF, IHC (p), IHC (wm), WB Western blot analysis for Dnmt3a using ABIN266067 at 2 ug/ml against 10 ?g of 293 cell lysate transfected with either mouse Dnmt3a (lane A) or mouse Dnmt3b (lane B). Immuno-staining of Dnmt3a using ABIN266067 at 5 ug/ml dilution on cultured HeLa cells. The nucleic staining is shown in most of the cells. 0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
361,00 €
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DNMT3A Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-DNMT3A Antikörper

  1. Human Monoclonal DNMT3A Primary Antibody für ChIP, CyTOF - ABIN266067 : Chen, Ueda, Xie, Li: A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. in The Journal of biological chemistry 2002 (PubMed)
    Zeige alle 83 Referenzen für 266067

  2. Human Polyclonal DNMT3A Primary Antibody für IHC (p), WB - ABIN387881 : Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. in Gene 1999 (PubMed)
    Zeige alle 12 Referenzen für 387881

  3. Human Polyclonal DNMT3A Primary Antibody für EIA, WB - ABIN951956 : Holz-Schietinger, Reich: The inherent processivity of the human de novo methyltransferase 3A (DNMT3A) is enhanced by DNMT3L. in The Journal of biological chemistry 2010 (PubMed)
    Zeige alle 3 Referenzen für 951956

  4. Human Polyclonal DNMT3A Primary Antibody für EIA, WB - ABIN951957 : Park, Zeng, Steer: Human DNA methyltransferase 3a does not associate with microRNAs in the regulation of DNA methylation. in Journal of cardiovascular translational research 2010 (PubMed)
    Zeige alle 3 Referenzen für 951957

  5. Human Polyclonal DNMT3A Primary Antibody für IHC (p), WB - ABIN387882 : Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999 (PubMed)
    Zeige alle 3 Referenzen für 387882

  6. Human Polyclonal DNMT3A Primary Antibody für IF (p), IHC (p) - ABIN669336 : Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015 (PubMed)
    Zeige alle 2 Referenzen für 669336

  7. Human Polyclonal DNMT3A Primary Antibody für WB - ABIN387865 : ODoherty, OShea, Fair: Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins. in Biology of reproduction 2012 (PubMed)

Weitere Antikörper gegen DNMT3A Interaktionspartner

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (zeige DNMT1 Antikörper), Dnmt3a, Hdac1 (zeige HDAC1 Antikörper), Kdm3a (zeige KDM3A Antikörper) and Uhrf1 (zeige UHRF1 Antikörper) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. The results show that DNMT3A mutations are associated with an unfavourable clinical outcome in our Southeast Asian AML (zeige RUNX1 Antikörper) patient cohort.

  2. DNMT3A mutations were rare in Chinese children with acute myeloid leukemia (zeige BCL11A Antikörper) (AML (zeige RUNX1 Antikörper)). The mutation positions were different from the hotspots reported in adult AML (zeige RUNX1 Antikörper). DNMT3A mutations may have adverse impact on prognosis of children with AML (zeige RUNX1 Antikörper).

  3. Somatic mutations driving clonal hematopoiesis occur mainly in DNMT3A and TET2 (zeige TET2 Antikörper) and have no significant impact on hematological phenotypes. There is a familial predisposition to acquire TET2 (zeige TET2 Antikörper) mutation.

  4. Findings identify a crucial role for DNMT3A(R882) mutations in driving acute myeloid leukemia anthracylcine chemoresist (zeige FLT3 Antikörper)ance and hi (zeige FLT3 Antikörper)ghlight the importance of ch (zeige NPM1 Antikörper)romatin rem (zeige NPM1 Antikörper)odeling in respons (zeige RUNX1 Antikörper)e to cytotoxic chemotherapy.

  5. Studies indicate that DNA methylation (zeige HELLS Antikörper) is mediated by three DNA (Cytosine-5-)-Methyltransferase (DNMTs): DNMT1 (zeige DNMT1 Antikörper) is responsible for the maintenance of methylation patterns after DNA replication whereas DNMT3A and DNMT3B (zeige DNMT3B Antikörper) carry out de novo methylation, and DNMT (zeige DNMT1 Antikörper) inhibitors have showed promising results in clinical trials of prostate cancer.

  6. dysregulation of DNMT3A and IGFBP5 (zeige IGFBP5 Antikörper) is relevant to preeclampsia. Thus, we propose that DNMT3A and IGFBP5 (zeige IGFBP5 Antikörper) can serve as potential markers and targets for the clinical diagnosis and therapy of preeclampsia.

  7. DOT1L (zeige DOT1L Antikörper) may play a critical role in DNMT3A-mutant leukemia.

  8. LOXL1 (zeige LOXL1 Antikörper) transcriptional activity was dramatically reduced when a recombinant DNMT3A was concomitantly overexpressed.

  9. these results demonstrated that miR (zeige MLXIP Antikörper)-143 targeted DNMT3A in gastric cancer (GC) cells and inhibit GC tumorigenesis and progression, which may provide a novel therapeutic target of GC.

  10. novel functions for Dnmt3a and Dnmt3b (zeige DNMT3B Antikörper) at enhancers that could contribute to their roles in disease and tumorigenesis, are reported.

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (zeige HELLS Antikörper) content are rather a function of time, and not a genetic component.

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. The effect of p53 (zeige TP53 Antikörper) expression on the development of cloned embryos, and its interaction with HDAC1 (zeige HDAC1 Antikörper) and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b (zeige DNMT3B Antikörper) were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Loss of DNMT3A expression is associated with development of malignancy.

  2. confirm the transformation potential of DNMT3A(R882H) Tet2 (zeige TET2 Antikörper)(-/-) progenitors and represent the first cooperative model in mice involving Tet2 (zeige TET2 Antikörper) inactivation driving lymphoid malignancies

  3. overexpression of Dnmt3a partially rescued the impairment of adipogenesis induced by AP2alpha (zeige TFAP2A Antikörper) knockdown.

  4. These data show that DNMT3a plays an important role in regulating embryonic cardiomyocyte gene expression, morphology and function.

  5. in addition to the established role of Dnmt3a in regulating self-renewal, Dnmt3a regulates tissue tropism and limits myeloid progenitor expansion in vivo.

  6. Dnmt3a mutations induced hematopoietic stem cell expansion, cooperated with mutations in the FMS-like tyrosine kinase 3 (zeige FLT3 Antikörper) gene (Flt3 (zeige FLT3 Antikörper)(ITD)) and the nucleophosmin (zeige NPM1 Antikörper) gene (Npm1 (zeige GJA1 Antikörper)(c)) to induce AML (zeige RUNX1 Antikörper) in vivo, and promoted resistance to anthracycline chemotherapy.

  7. miR (zeige MLXIP Antikörper)-29a/b/c repressed DNMT3A expression by directly targeting its 3' untranslated region (3' UTR (zeige UTS2R Antikörper)). Our data reveal a novel mechanism of miR (zeige MLXIP Antikörper)-29a/b/c in the regulation of adipogenesis

  8. DOT1L (zeige DOT1L Antikörper) may play a critical role in DNMT3A-mutant leukemia.

  9. Thyroid regulation of Dnmt3a may be an evolutionarily conserved mechanism for modulating global changes in DNA methylation (zeige HELLS Antikörper) during postnatal neurological development.

  10. three DNA methyltransferases, Dnmt1 (zeige DNMT1 Antikörper), Dnmt3a, and Dnmt3b (zeige DNMT3B Antikörper), have been identified. Dnmt3a and Dnmt3b (zeige DNMT3B Antikörper) are responsible for establishing DNA methylation (zeige HELLS Antikörper) patterns produced through their de novo-type DNA methylation (zeige HELLS Antikörper) activity in implantation stage embryos and during germ cell differentiation. Dnmt3-like (Dnmt3l (zeige TRDMT1 Antikörper)), which is a member of the Dnmt3 family but does not possess DNA methylation (zeige HELLS Antikörper)

DNMT3A Antigen-Profil

Protein Überblick

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit DNMT3A

  • DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A) Antikörper
  • DNA methyltransferase 3A (dnmt3a) Antikörper
  • DNA (cytosine-5-)-methyltransferase 3 alpha (Dnmt3a) Antikörper
  • DNA methyltransferase 3A (Dnmt3a) Antikörper
  • DNMT3A Antikörper
  • DNMT3A2 Antikörper
  • M.HsaIIIA Antikörper
  • MmuIIIA Antikörper

Bezeichner auf Proteinebene für DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5)-methyltransferase 3A , DNA methyl transferase alpha , DNA methyltransferase 3A , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA

GENE ID SPEZIES
482996 Canis lupus familiaris
694822 Macaca mulatta
739139 Pan troglodytes
100037301 Sus scrofa
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100594618 Nomascus leucogenys
100529107 Anolis carolinensis
1788 Homo sapiens
421991 Gallus gallus
100510798 Felis catus
100055881 Equus caballus
359716 Bos taurus
444984 Rattus norvegicus
13435 Mus musculus
Ausgewählte Anbieter für anti-DNMT3A (DNMT3A) Antikörper
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